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COX

COX

货号 产品名 CAS号 信息
CSN12344 Valdecoxib 181695-72-7 Valdecoxib is a potent COX inhbitor that selectively inhibitors COX-2 with IC50 of 5 nM.
CSN12172 Ufenamate 67330-25-0 Ufenamate is a COX inhibitor, used as a topical analgesic.
CSN12136 Tribenoside 10310-32-4 Tribenoside is a vasoprotective and a mixture of the α- und β-anomers.
CSN22101 Tetrahydropalmatine HCl 6024-85-7 Tetrahydropalmatine inhibits the LPSinduced production of COX-2 protein and mRNA in a dose-dependent manner.
CSN12019 Suprofen 40828-46-4 Suprofen is a COX1/2 inhibitor and a non-steroidal anti-inflammatory drug (NSAID).
CSN24305 Sulindac sulfone 59973-80-7 Sulindac sulfone inhibited K-ras-dependent COX-2 protein expression, which resulted in a decrease in prostaglandin synthase E2 production.
CSN12016 Sulindac 38194-50-2 Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) and is thought to act on enzymes COX-1 and COX-2, inhibiting prostaglandin synthesis.
CSN23106 SC 236 170569-86-5 SC-236 is an orally active inhibitor of COX-2. SC-236 displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.
CSN19979 Sanggenon D 81422-93-7 Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L.
CSN25628 PTUPB 1287761-01-6 PTUPB is a novel dual COX2 and sHE (soluble epoxide hydrolase) inhibitor. Treatment with PTUPB reduced body weight, liver weight, liver triglyceride and cholesterol content, and the expression of lipolytic/lipogenic and lipid uptake related genes (Acc, Cd36, and Cidec) in HFD mice. This made it be a promising potential therapy for liver steatosis associated with obesity.
CSN11226 Propyphenazone 479-92-5 Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.
CSN24044 Propacetamol HCl 66532-86-3 Propacetamol HCl is the hydrochloride form of Propacetamol, which is a prodrug of paracetamol (acetaminophen) with improved water solubility. Propacetamol is an analgesic drug delivered by IV when oral application of NSAID is not appropriate or contradicted.
CSN16384 Pranoprofen 52549-17-4 Pranoprofen is a non-steroidal COX inhibitor with anti-inflammatory effects, used in treatment of ophthalmology.
CSN12646 Piroxicam 36322-90-4 Piroxicam is a selective COX1 inhibitor with anti-inflammatory effects.
CSN12368 Parecoxib Sodium 198470-85-8 Parecoxib Sodium, a water-soluble and injectable prodrug of valdecoxib, is a COX2 inhibitor used for the short-term treatment of postoperative pain in adults.
CSN12605 Naproxen 22204-53-1 Naproxen is a COX inhibitor for COX1/2 with IC50 of 8.7 and 5.2 μM, respectively.
CSN27387 Metyrosine 672-87-7 Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.
CSN24828 Meclofenamic acid 644-62-2 Meclofenamic acid is a balanced COX-1/COX-2 inhibitor and a non-selective gap junction blocker.
CSN11367 Meclofenamate Sodium 6385-02-0 Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea.
CSN11337 Loxoprofen 68767-14-6 Loxoprofen is a non-steroidal anti-inflammatory drug (NSAID) and propionic acid derivative.
CSN11332 Lornoxicam 70374-39-9 Lornoxicam is a COX inhibitor with IC50 of 5 nM and 8 nM for COX1 and 2 respectively. It's a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of various types of pain.
CSN11253 Ketorolac Tromethamine 74103-07-4 Ketorolac is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.
CSN11252 Ketoprofen 22071-15-4 Ketoprofen is a dual COX1/2 inhibitor with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively, and used as a nonsteroidal anti-inflammatory drug (NSAID) to treat arthritis-related inflammatory pains.
CSN25653 KBT-3022 101001-34-7 KBT3022 is a COX inhibitor.
CSN12756 Indomethacin 53-86-1 Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling.
CSN11203 Indomethacin Farnesil 85801-02-1 Indometacin farnesil is a prodrug of the non-steroidal anti-inflammatory drug indometacin.
CSN25380 Ibuprofen piconol 64622-45-3 Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns.
CSN25380 Ibuprofen piconol 64622-45-3 Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns.
CSN10177 Ibuprofen Lysine 57469-77-9 Ibuprofen lysine is a non-steroidal anti-inflammatory drug (NSAID).
CSN11183 Ibuprofen 15687-27-1 Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively, and is used for pain relief, fever reduction and for reducing swelling.
CSN11030 Flunixin Meglumine 42461-84-7 Flunixin meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity.
CSN12744 Flufenamic Acid 530-78-9 Flufenamic Acid is a COX inhibitor and prevents formation of prostaglandins, binds to and reduce the activity of prostaglandin F synthase and activate TRPC6, it is a NSAID drug.
CSN25325 FPL 62064 103141-09-9 FLP 62064 is a potent 5-lipoxygenase (5-LOX) and COX-2 dual inhibitor. FLP 62064 has potently anti-inflammatory activity.
CSN11003 Fenoprofen Calcium 34597-40-5 Fenoprofen Calcium is COX-1/2 inhibitor used as an NSAID. It can also inhibit fatty acid oxidation and acts as a peroxisome proliferator.
CSN10999 Fenbufen 36330-85-5 Fenbufen is a phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug.
CSN10969 Etoricoxib 202409-33-4 Etoricoxib is a selective COX2 inhibitor with IC50 of 1.1 ± 0.1 μM and 116 ± 8 μM for COX1.
CSN10309 Dipyrone 68-89-3 Dipyrone is a non-steroidal antiinflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX.
CSN10793 Diclofenac Diethylamine 78213-16-8 Diclofenac diethylamine is a non-selective COX inhibitor used as a nonsteroidal anti-inflammatory drug (NSAID).
CSN10773 Deracoxib 169590-41-4 Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID).
CSN10595 Celecoxib 169590-42-5 Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM.
CSN27248 3-(4-(Methylsulfonyl)phenyl)-4-phenyl-5-(trifluoromethyl)isoxazole 340267-36-9 CAY10404 is a potent and highly selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 1 nM. CAY10404 exhibits no inhibition of COX-1 (IC50>500 µM) . CAY10404 is a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSCLC cells. CAY10404, a diarylisoxazole, has good analgesic, anti-inflammatory, and anti-cancer activities .
CSN10518 Butibufen 55837-18-8 Butibufen, is a cyclooxygenase inhibitor used to treat inflammatory and rheumatic disorders.
CSN10398 Benorylate 5003-48-5 Benorylate HCl is an ester-linked codrug of aspirin with paracetamol, used as an anti-inflammatory and antipyretic medication.
CSN10286 Aminoprofen 82821-47-4 Aminoprofen is NSAID (non-steroidal anti-inflammatory drug) and non selective COX inhibitor. Aminoprofen is used to relieve mild to moderate pain.
CSN14397 alpha-Viniferin 62218-13-7 alpha-Viniferin, a natural product isolated and purified from the herb of Carex humilis Leyss., a specific, reversible and noncompetitive AChE inhibitor (IC50 = 2.0 mM), exhibits a dose-dependent inhibition on cyclooxygenase activity, where 50% of inhibition (IC50) was shown at a final concentration of about 7 mM, and has anti-inflammatory activity, down-regulating STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-gamma-stimulated macrophages.
CSN10205 Acetaminophen 103-90-2 Acetaminophen is a COX inhibitor for COX-1 and COX-2 with IC50 of 113.7 μM and 25.8 μM, respectively.
CSN10201 Aceclofenac 89796-99-6 Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of diclofenac.
CSN27388 3,3'-Diiodo-L-thyronine 4604-41-5 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity.
CSN27376 2,6-Dichlorodiphenylamine 15307-93-4 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
CSN14023 (-)-Epiafzelechin 24808-04-6 (-)-Epiafzelechin, a natural product isolated and purified from the herbs of Celastrus orbiculatus with antioxidant activity, exhibits various modes of action in suppressing HSV-2 multiplication, a dose-dependent inhibition on the COX activity with an IC50 value of 15 µM, and significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment.
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