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PDK is a kinase enzyme which acts to inactivate the enzyme pyruvate dehydrogenase by phosphorylating it using ATP.

PDK

货号 产品名 CAS号 信息
CSN17521 PS-48 1180676-32-7 PS48 is a phosphoinositide-dependent protein kinase-1 (PDK1) activator with Kd value of 10.3 μM and binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site.
CSN33232 PS210 1221962-86-2 PS-210 is a selective activator of PDK1 activator. It acts by binding to the PIF-pocket allosteric docking site.
CSN26736 1-(1-(Piperidin-4-yl)-1H-pyrazol-4-yl)anthracene-9,10-dione 2310262-10-1 PDK4-IN-1 is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 has antidiabetic, anticancer and anti-allergic activity[1].
CSN17379 MP7 1001409-50-2 PDK1 inhibitor is a potent and selective inhibitor of PDK1 with potential as anticancer agent.
CSN25617 PDK4-IN-1 HCl 2310262-11-2 PDK-4 Inhibitor compound 8c HCl is an allosteric PDK-4 inhibitor with IC50 value of 84nM.
CSN12988 2-Amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide 742112-33-0 OSU-03012 is a potent inhibitor of recombinant PDK-1 with IC50 of 5 μM and 2-fold increase in potency over OSU-02067.
CSN27211 JX06   729-46-4 JX06 is a selective covalent PDK1 inhibitor with IC50 values of 49, 101 and 313nM for PDK-1, PDK-2 and PDK-3, respectively.
CSN17589 GSK2334470 1227911-45-6 GSK2334470 is a PDK1 inhibitor with IC50 of ~10 nM, with no activity at other close related AGC-kinases.
CSN12711 BX795 702675-74-9 BX795 is a potent and selective dual inhibitor of TBK1/PDK1 with IC50s of 2 nM/6 nM respectively, also inhibit Aurora B and IκB kinase ε (IKKε).
CSN19146 BX517 850717-64-5 BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.
CSN17175 BX-912 702674-56-4 BX-912 is a selective inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1) with IC50 of 12 nM, showing > 10 fold selectivity over PKA, PKC, C-Kit, EGFR etc.
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