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Alkaloids

Alkaloids

货号 产品名 CAS号 信息
CSN16167 Yohimbine 146-48-5 Yohimbine, a natural product isolated and purified from the peel of Corynante yohimbe, is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM.
CSN19381 1H-Purine-2,6(3H,7H)-dione 69-89-6 Xanthine is a natural occuring purine-base adenosine receptor antagonist, from which a number of stimulants such as caffeine and theobromine are derived.
CSN18358 Veratramine 60-70-8 Veratramine is a natually occuring alkaloid isolated from the rhizomes of Veratrum and can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells for it is an analog of cyclopamine.
CSN16278 2,3,9,10-Tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline 2934-97-6 Tetrahydropalmatine is an isoquinoline alkaloid mainly found in the genus Corydalis with analgesic effects. It antagonizes dopamine D1, and D2 receptors as well as actions at dopamine D3, alpha adrenergic and serotonin receptors, with Ki values of 124 nM and 388 nM for D1 and D2 dopamine receptors, respectively.
CSN16469 Sophocarpine 6483-15-4 Sophocarpine is a naturally-occuring HERG K+ channel blocker with IC50 ranging in 100-300 μM found from plant Sophora flavescens.
CSN19363 (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 86639-52-3 SN-38 is an active metabolite of CPT-11 that inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
CSN16625 Sanguinarine 2447-54-3 Sanguinarine is a benzophenanthridine alkaloid which has anti-microbial, anti-oxidant and anti-inflammatory properties. It is a specific inhibitor of Rac1b, and with potential antitumor activity.
CSN16640 7,8-Dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(13H)-one 84-26-4 Rutaecarpine, a COX-2 inhibitor, is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs.
CSN16137 (R)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol 130-95-0 Quinine is a medication used to treat malaria and babesiosis, isolated from the bark of a cinchona tree.
CSN14156 Pseudopalmatine 19716-66-6 Pseudocolumbamine is a natural product isolated and purified from the herbs of Tinospora sinensis with antiplasmodial activity ,it's also a AChE inhibitor with IC50 of 1.8 μM.
CSN19448 7-Methyl-6,7,8,9-tetrahydro-[1,3]dioxolo[4',5':5,6]benzo[1,2-c][1,3]dioxolo[5',4':4,5]benzo[1,2-g]azecin-15(16H)-one 130-86-9 Protopine is a naturally occuring benzylisoquinoline alkaloid found in plants of the family papaveraceae. It acts as an analgesic and can inhibit histamine H1 receptors.
CSN15281 Periglaucine A 1025023-04-4 Periglaucine an inhibits hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells.
CSN16615 Norisoboldine 23599-69-1 Norisoboldine is an isoquinoline alkaloid isolated and purfied from the roots of Lindera aggregata, which acts as an AhR agonist, and enhances the function of the adenosine A1 receptor.
CSN15263 Norcepharadione B 57576-41-7 Norcepharadione B, a natural product isolated and purified from the herbs of Houttuynia cordata Thunb. with good inhibitory activity against the replication of HSV-1, exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.
CSN16213 N-(4-Hydroxy-3-methoxybenzyl)nonanamide 2444-46-4 Nonivamide, an analog of capsaicin, is agonist of transient receptor potential vanilloid type 1 (TRPV1). It can be extracted from the fruits of Capsicum annuum L..
CSN14183 N-Nornuciferine 4846-19-9 N-Nornuciferine, a natural product isolated and purified from the fruits of Piper nigrum, can competitively inhibit CYP2D6 activity with Ki values of 2.34 uM.
CSN14200 N-Benzylpalmitamide 74058-71-2 Macamide B is a natural product isolated and purified from the herbs of Lepidium meyenii Walp.
CSN14568 Lauterine 28200-65-9 Lauterine is a natural DNA topoisomerase inhibitor isolated and purified from the plants of Guatteria elata R. E. Fries.
CSN18732 Jatrorrhizine 3621-38-3 Jatrorrhizine is a protoberberine alkaloid isolated from some plant species like Enantia chlorantha. It can inhibit MAO-A and MAO-B noncompetitively with IC50 value of 4μM and 62μM, respectively. Also, it has antiinflammatory, antimicrobial and antifungal activity.
CSN19872 3-Hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium chloride 6681-15-8 Jatrorrhizine HCl is a protoberberine alkaloid isolated from some plant species like Enantia chlorantha. It can inhibit MAO-A and MAO-B noncompetitively with IC50 value of 4μM and 62μM, respectively. Also, it has antiinflammatory, antimicrobial and antifungal activity.
CSN19291 (5R,9R,E)-5-Amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one 102518-79-6 Huperzine A is a naturally occurring sesquiterpene alkaloid AChE inhibitor.
CSN16848 (11S,31S)-16,36,54-Trimethoxy-12,32-dimethyl-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphan-37-ol 436-77-1 Fangchinoline is an isolate of Stephania tetrandra and has anticancer activity through induction of G1 arrest in breast cancer cells.
CSN19004 Epiberberine chloride 889665-86-5 Epiberberine chloride, a natural alkaloid, is a BACE1 inhibitor, which also exhibits inhibition activity on CYP2D6 and aldose reductase, alpha-adrenoceptors, acetylcholinesterase (AChE), butyrylcholinesterase, and b-site amyloid precursor protein cleaving enzyme 1.
CSN14176 Enniatin B 917-13-5 Enniatin B, a natural product isolated and purified from the Pencillium urticae with anticancer and antiangiogenic properties, can decrease Monocytes' endocytosis ability and an increase of CD71.
CSN14190 Dihydroevocarpine 15266-35-0 Dihydroevocarpine, a natural product isolated and purified from the fruits of Evodia rutaecarpa, is a moderate modulator of p-glycoprotein (p-gp) activity. Dihydroevocarpine also shows more potent inhibitory effects against MAO-B compared to MAO-A and potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 mg/mL.
CSN14038 Deoxyvasicinone 530-53-0 Deoxyvasicinone, a natural product isolated and purified from the herbs of Galium aparine L., can be considered as promising lead molecules for the development of more potent inhibitors of NEDD8-activating enzyme.
CSN14154 Dehydrocrenatidine 65236-62-6 Dehydrocrenatidine, a natural product isolated and purified from the barks of Picrasma quassioides, is a JAK-specific inhibitor, which inhibits JAK2-JH1 kinase activity in vitro , represses constitutively activated JAK2 and STAT3, as well as interleukin-6-, interferon-α-, and interferon-γ-stimulated JAK activity, and STAT phosphorylation, and suppresses STAT3 and STAT1 downstream gene expression.
CSN14730 Crenatine 26585-14-8 Crenatine possesses antibacterial but no antifungal activity.
CSN18353 Coptisine chloride 6020-18-4 Coptisine Chloride is a naturally occuring cytotoxic alkaloid found in Chinese goldthread which shows cytotoxic effect on heptoma and leukemic cells and is reported to block cell cycle progression.
CSN19868 Chelerythrine 34316-15-9 Chelerythrine, a natural product isolated and purified from the herbs of Chelidonium majus with potent antimanic, antiproliferatvie and antitumor effect, can inhibit telomerase activity, and is a well-known protein kinase C inhibitor.
CSN14179 Caulilexin C 30536-48-2 Caulilexin C is a natural product isolated and purified from the herbs of Isatis idigotica, showing inhibitory activity on human Acyl CoA: cholesterol transferase I (hACATI) and on human Acyl CoA: cholesterol transferase 2 (hACAT2) at 100 ug/mL.
CSN16581 (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 7689-03-4 Camptothecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231.
CSN14165 Calyxamine B 150710-72-8 Calyxamine B is a natural product isolated and purified from the herbs of Salsola tetrandra, has inhibitory activity on acetylcholinesterase, the effect is comparable to the natural inhibitors.
CSN18309 Aconine 509-20-6 Aconine is a natural product.
CSN16855 (±)-Huperzine A 120786-18-7 (±)-Huperzine A is an active Lycopodium alkaloid extracted from traditional Chinese herbs of Lycopodium serratum, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).
CSN14992 (Z)-Akuammidine 113973-31-2 (Z)-Akuammidine is a potent μ-opioid agonist isolated and purified from the roots of Gelsemium elegans.
CSN19330 (41S,7aS,13aR,13bR)-Dodecahydro-1H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10(41H)-one 519-02-8 (+)-Matrine is a naturally occuring κ-opioid and μ-opioid receptor agonist.
CSN50075 RTC13 1359825-94-7
CSN50115 15-Oxospiramilactone 1053172-87-4
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