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MDM2

MDM2

货号 产品名 CAS号 信息
CSN18271 SJ-172550 431979-47-4 SJ-172550 is a small molecule inhibitor of MDMX and competes for the wild type p53 peptide binding to MDMX with an EC50 of 5 μM.
CSN17669 SAR405838 1303607-60-4 SAR405838 is a highly potent and selective MDM2 inhibitor, binds to MDM2 with Ki= 0.88 nM and has high specificity over other proteins.
CSN17676 RO8994 1309684-94-3 RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).
CSN16216 RG7388 1229705-06-9 RG7388 is a potent and selective p53–MDM2 inhibitor which can block the binding of MDM2 to p53 with IC50 value of 30 nM.
CSN16567 RG7112 939981-39-2 RG7112 is a small-molecule MDM2 antagonist which can occupy the p53-binding pocket of MDM2.
CSN19741 PK11195 85532-75-8 PK11195 is a 2‑Phenylindolylglyoxylyldipeptide Murine Double Minute2 (MDM2)/Translocator Protein (TSPO)/Human Constitutive Androstane Receptor (hCAR) Inhibitor, and is potentially useful for the Treatment of Gliomas.
CSN19111 NVP-CGM097 Stereoisomer 2070009-54-8 NVP-CGM097 stereoisomer is a stereoisomer of NVP-CGM097.
CSN17682 NVP-CGM097 1313363-54-0 NVP-CGM097 is a potent, selective and species specific p53-Mdm2 inhibitor with IC50 of 1.7±0.1 nM.
CSN17157 Nutlin 3b 675576-97-3 Nutlin 3b is a MDM2/p53 antagonist or inhibitor with IC50 of 13.6 μM.
CSN17156 Nutlin 3a 675576-98-4 Nutlin 3a is an improved MDM2-p53 interation antagonist thus acting as p53 (TP53) activator and stabilizer. It is a more potent diastereoisomer of Nutlin-3.
CSN12388 Nutlin 3(Random Configuration) 890090-75-2 Nutlin 3(Random Configuration) is an MDM2 antagonist which can activate p53 pathway through inhibition of p53-MDM2 interaction.
CSN18807 Nutlin 3 548472-68-0 Nutlin 3 is an MDM2 antagonist which can activate p53 pathway through inhibition of p53-MDM2 interaction.
CSN20477 NSC 66811 6964-62-1 NSC 66811 is a potent MDM2 inhibitor with Ki value of 120 nM which can disrupt MDM2-p53 interaction and activate p53 function.
CSN17369 NSC 59984 803647-40-7 NSC 59984 is a reactivator of p53 which targets various mutant p53 to restore wild-type p53 pathway via the activation of p73 in cancer cells. It could induce p53 mutant protein degradation via MDM2-mediated ubiquitination.
CSN18894 MX69 1005264-47-0 MX69 is a dual inhibitor of MDM2 and XIAP which can induce MDM2 downregulation resulted not only in inhibition of XIAP expression, but also in activation of p53.
CSN22088 NVP-HDM 201 1448867-41-1 HDM201 binds to the p53 binding-site of the Mdm2 protein, disrupting the interaction of the two proteins and leading to the activation of the p53 pathway. It induces robust p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor cells. HDM201 exhibits highly selectivity across a panel of cancer cell lines.
CSN19676 BI-0252 1818291-27-8 BI-0252 is a chemically stable and orally active inhibitors of the MDM2-p53 interaction.
CSN19254 APG-115 1818393-16-6 APG-115 is a compound with a very high affinity to MDM2 (Ki < 1 nM), potent cellular activity, and an excellent oral pharmacokinetic profile.
CSN21087 DS-3032b 2095625-97-9
CSN23123 SP 141 1253491-42-7
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