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Bcr-Abl

Bcr-Abl

货号 产品名 CAS号 信息
CSN16658 WP1130 856243-80-6 WP1130 is a selective small molecular deubiquitinase (USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and a Bcr/Abl destruction pathway activator with an IC50 of 1.8 μM for K562 cells.
CSN22290 SNIPER(ABL)-062 2140260-89-3 SNIPER(ABL)-062 is a potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation; shows desirable binding affinities against ABL1, cIAP1/2, and XIAP (IC50=80-500 nM), inhibits BCR-ABL-mediated signaling pathways and CML proliferation in cells expressing BCR-ABL.
CSN18591 Radotinib 926037-48-1 Radotinib is a selective BCR-ABL1 inhibitor with IC50 of 34 nM, also inhibits platelet-derived growth factor receptor (PDGFR), is used to treat cancers and Chronic Myeloid Leukemia.
CSN22517 Target Protein-binding Moiety 8 910297-51-7 PROTAC Bcr-Abl-binding moiety 1 is a Dasatinib-based warhead ligand for conjugation reactions of PROTAC targeting on Bcr-Abl.
CSN12687 Ponatinib   943319-70-8 Ponatinib is a potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively.
CSN12295 Nilotinib HCl H2O 923288-90-8 Nilotinib monohydrochloride is a Bcr-Abl inhibitor with IC50 < 30 nM.
CSN11559 Nilotinib 641571-10-0 Nilotinib is a Bcr-Abl inhibitor with IC50 less than 30 nM in Murine myeloid progenitor cells.
CSN12740 Lyn-IN-1 887650-05-7 Lyn-IN-1 is a potent and selective dual Bcr-Abl/Lyn inhibitor with potential antineoplastic activity, it is an orally bioavailable 2-phenylaminopyrimidine derivative.
CSN17632 GZD824 1257628-77-5 GZD824 is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl (WT) and Bcr-Abl (T315I) with IC50 of 0.34 and 0.68 nM, respectively.
CSN18803 GZD824 Dimesylate 1421783-64-3 GZD824 dimesylate is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl (WT) and Bcr-Abl (T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.
CSN15689 GNF-7 839706-07-9 GNF-7 inhibits Bcr-Abl WT and Bcr-Abl T315I with IC50 of 133 nM and 61 nM, respectively.
CSN12398 GNF-5 778277-15-9 GNF-5 is a selective non-ATP competitive inhibitor of Bcr-Abl with IC50 of 220 nM, it's an analogue of GNF-2 with improved pharmacokinetic properties.
CSN13825 GNF-2 778270-11-4 GNF-2 is a highly selective non-ATP competitive inhibitor of oncogenic Bcr-Abl activity (IC50 = 0.14 μM).
CSN17178 Flumatinib Mesylate 895519-91-2 Flumatinib mesylate, a derivative of imatinib, is a multi-kinase inhibitor with IC50 Values of 1.2 nM, 307.6 nM and 2662 nM for c-Abl, PDGFRβ and c-Kit respectively.
CSN18538 Flumatinib 895519-90-1 Flumatinib is a multi-kinase inhibitor with IC50 Values of 1.2 nM, 307.6 nM and 2662 nM for c-Abl, PDGFRβ and c-Kit respectively.
CSN16096 DPH 484049-04-9 DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation.
CSN13733 DCC-2036 1020172-07-9 DCC-2036 is a conformational control Bcr-Abl inhibitor for Abl1 (WT) and Abl1 (T315I) with IC50 of 0.8 nM and 4 nM, also inhibits SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2.
CSN12769 Dasatinib Monohydrate 863127-77-9 Dasatinib is a potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of < 1 nM, 0.8 nM and 79 nM, respectively.
CSN16497 Dasatinib 302962-49-8 Dasatinib is a potent and dual Abl/ Src inhibitor IC50 of < 1 nM/0.8 nM respectively and also inhibits c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM.
CSN18475 Dasatinib HCl 854001-07-3 Dasatinib hydrochloride is a potent and dual Abl/ Src inhibitor IC50 of < 1 nM/0.8 nM respectively and also inhibits c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM.
CSN21248 BCR-ABL-IN-1 188260-50-6 BCR-ABL-IN-1 is an inhibitor of BCR-ABL tyrosine kinase, with a pIC50 of 6.46, and may be used in the research of chronic myelogenous leukemia.
CSN19269 Bafetinib   859212-16-1 Bafetinib is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM in cell-free assays, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit.
CSN18872 Asciminib 1492952-76-7 Asciminib is a potent and selective allosteric Bcr-Abl inhibitor and inhibits Ba/F3 cells grown with an IC50 of 0.25 nM.
CSN23049 PPY A 875634-01-8
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