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Glucokinase

Glucokinase

货号 产品名 CAS号 信息
CSN18191 RO-28-1675 300353-13-3 Ro 28-1675 is a potent allosteric GK activator with a SC1.5 value of 0.24± 0.0019 μM.
CSN22238 PF-04991532 1215197-37-7 PF-04991532 is a potent, hepatoselective glucokinase activator with EC50s of 80 and 100 nM in human and rat, respectively.
CSN26253 Nerigliatin 1245603-92-2 PF-04937319 is a glucokinase activator (GKA) with EC50 value of 154.4  μM, which is under development for the treatment of type 2 diametes mellitus.
CSN26447 (S)-3-((6-(Ethylsulfonyl)pyridin-3-yl)oxy)-5-((1-hydroxypropan-2-yl)oxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide methanesulfonate 1137916-97-2 MK-0941 mesylate is a glucokinase activator (GKA) potentially for the treatment of type 2 diabetes. MK-0941 led to improvements in glycemic control that were not sustained. MK-0941 was associated with an increased incidence of hypoglycemia and elevations in triglycerides and blood.
CSN16830 Globalagliatin 1234703-40-2 LY2608204 is an activator of glucokinase (GK) with EC50 of 42 nM.
CSN22830 GKA50 851884-87-2 GKA 50 is a potent glucokinase activator with EC50 of 33 nM.
CSN20177 Dorzagliatin 1191995-00-2 Dorzagliatin is a glucokinase activator on glucose metabolism.
CSN21071 AMG3969 1361224-53-4 AMG-3969 is a glucokinase-GKRP disruptor with IC50 value of 343nM and potently reverses the inhibitory effect of GKRP on GK activity.
CSN19038 AM-2394 1442684-77-6 AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM.
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