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Three members of the Cdc25 gene family are described in mammals: Cdc25A, B, and C. These genes encode highly similar dual-specificity phosphatases which are able to dephosphorylate both phospho-threonine and -tyrosine residues. The different members of Cdc25 are responsible for influencing transition between specific phases of the cell cycle through their dephosphorylation of crucial tyrosine and threonine residues on inactivated Cdks.

Cdc25

货号 产品名 CAS号 信息
CSN25665 BN82002 396073-89-5 BN82002 is a potent, selective and irreversible inhibitor of CDC25 phosphatase family with IC50 values of 2.4µM, 3.9µM, 6.3µM, 5.4µM and 4.6µM for 25A, 25B2, 25B3, 25C and 25C-cat, respectively. BN82002 exhibited anti-inflammatory functions via targeting AKT2.
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