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mGluR

mGluR

货号 产品名 CAS号 信息
CSN23268 YM 202074 299900-83-7 YM-202074 is a high affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. YM-202074 binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. It inhibits mGlu1-mediated inositol phosphates production (IC50 = 8.6 nM in rat cerebellar granule cells).
CSN23198 XAP 044 196928-50-4 XAP044 is a potent and selective mGlu7 antagonist (IC50 = 88 nM). It inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. XAP044 displays no effects on the LTP of mGlu7 deficient mice.
CSN24066 VU6005649 2137047-43-7 VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively.
CSN20205 VU0424238 1396337-04-4 VU0424238 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 selected for clinical evaluation of psychiatric and neurodegenerative disorders.
CSN23184 VU 0422288 1630936-95-6 VU0422288, also known as ML 396, is a positive allosteric modulator (EC50 values are 108, 125 and 146 nM for mGlu4, mGlu8 and mGlu7 respectively).
CSN23183 VU 0409106 1276617-62-9 VU0409106 is a potent and selective inhibitor of mGlu5.
CSN23186 VU 0469650 1443748-47-7 VU 0469650 hydrochloride is a potent and selective negative allosteric modulator of mGlu1 (IC50 = 99 nM). VU 0469650 hydrochloride exhibits >100-fold selectivity for mGlu1 over mGlu2-8 and 68 other GPCRs, ion channels, kinases and transporters.
CSN16002 VU 0364770 61350-00-3 VU 0364770 is a brain-penetrant and positive allosteric modulator of mGlu4 receptors with EC50 values of 290 nM. It also exhibits affinity for MAO-B and MAO-A with Ki values of 0.72 μM and 8.5 μM, respectively.
CSN17179 VU 0364439 1246086-78-1 VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.
CSN16570 VU 0357121 433967-28-3 VU 0357121 is a positive allosteric mGlu5 receptors modulator with EC50 value of 33 nM.
CSN23181 VU 0155041 1093757-42-6 UV0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively).
CSN12115 Topiramate 97240-79-4 Topiramate is a selective GluK1 kainate receptors (GluR5) antagonist with IC50 value of 0.46 μM which can act as a positive allosteric modulator of GABAA receptor-mediated currents, inhibit Nav channels and L-type Ca2+ channels.
CSN23141 TASP 0433864 1431980-60-7 TASP0433864 is a novel positive allosteric modulator of metabotropic glutamate 2 receptor. TASP0433864 exhibited PAM activity at human and rat mGlu2 receptors with EC50 values of 199 and 206 nM, respectively, without exerting agonist activity at rat mGlu2 receptor. TASP0433864 produced a leftward and upward shift in the concentration-response curve of glutamate-increased guanosine 5'-O-(3-[(35)S]thio)triphosphate binding to mGlu2 receptor. The inhibitory effect of TASP0433864 on cortical activation was also observed in the mouse 2-deoxy-glucose uptake study. TASP0433864 is a selective mGlu2 receptor PAM with antipsychotic activity, and the attenuation of excess glutamatergic neurotransmission may be involved in the action of TASP0433864.
CSN23124 Spaglumic Acid 3106-85-2 Spaglumic Acid is a neuropeptide found in millimolar concentrations in brain.
CSN23116 SIB 1757 31993-01-8 SIB-1757 is a highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype. SIB-1757 displays an IC50 value of 0.4 μM at hmGlu5 compared with > 30 μM at hmGlu1b, hmGlu2, hmGlu4, hmGlu6, hmGlu7 and hmGlu8.
CSN23203 YM 230888 446257-23-4 Selective mGlu1 antagonist
CSN23070 Ro 64-5229 246852-46-0 Ro64-5229 is a selective, non-competitive mGlu2 antagonist. Ro64-5229 inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM).
CSN18975 Ro 67-7476 298690-60-5 Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors.
CSN23187 VU 29 890764-36-0 Potent positive allosteric modulator of mGlu5 receptors
CSN23182 VU 0155041 Sodium Salt 1259372-69-4 Potent positive allosteric modulator of mGlu4 receptors; sodium salt of VU 0155041 (Cat. No. 3248)
CSN23155 TC-N 22A 1314140-00-5 Potent and selective positive allosteric modulator of mGlu4 receptors
CSN13647 MTEP HCl 1186195-60-7 MTEP HCl is a potent, selective and non-competitive mGlu5 antagonist with IC50 and Ki of 5 nM and 16 nM, respectively.
CSN11477 MPEP 96206-92-7 MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors.
CSN15940 MPEP HCl 219911-35-0 MPEP HCl is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype with IC50 of 36 nM.
CSN23218 MMPIP 479077-02-6 MMPIP HCl is an allosteric mGlu7-selective receptor antagonist.
CSN18984 Mavoglurant Racemate 1636881-61-2 Mavoglurant racemate is the racemate of mavoglurant.
CSN12419 LY404039 635318-11-5 LY404039 is an inhibitor for mGluR1 (Ki=149 nM) and mGluR2 (Ki= 92 nM), which can also inhibit dopamine receptor.
CSN11347 LY341495 201943-63-7 LY341495 is a highly potent and selective group II metabotropic glutamate receptor antagonist.
CSN16643 LY2979165 1311385-32-6 LY2979165 is a mGlu2 agonist, a drug candidate drug used to treat bipolar disorder.
CSN19844 LY 456236 HCl 338736-46-2 LY 456236 HCl is a selective mGlu1 receptor antagonist (IC50 values are 143 nM and > 10 μM for mGlu1 and mGlu5 receptors respectively).
CSN19861 LSN 2463359 1401031-52-4 LSN 2463359 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM).
CSN11296 L-Glutamic Acid Monosodium 142-47-2 L-Glutamic Acid Monosodium is an excitatory amino acid neurotransmitter as an agonist at GluR and NMDA receptor.
CSN19846 Kainic Acid 487-79-6 Kainic acid is a selective agonist at kainate receptors. Potent excitant and neurotoxin.
CSN18977 JNJ-16259685 409345-29-5 JNJ16259685 is a selective antagonist at the mGlu1 receptors, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM.
CSN17481 JNJ-40411813 1127498-03-6 JNJ-40411813 is a positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.
CSN18792 IEM 1754 Dihydrobromide 162831-31-4 IEM 1754 dihydrobromide is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
CSN23202 YM 202074 fumarate salt 299900-84-8 High affinity, selective mGlu1 antagonist
CSN20520 GET-73 202402-01-5 GET-73 is a mGlu5 receptor allosteric modulator potentially for the treatment of alcoholism.
CSN18973 FPTQ 864863-72-9 FPTQ is mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1 respectively.
CSN24075 Foliglurax 1883329-51-8 Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 79 nM[1]. Antiparkinsonian effect[1].
CSN10975 Evans Blue 314-13-6 Evans blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT).
CSN13492 D-Glutamine 5959-95-5 D-Glutamine is a non-essential amino acid involved in many metabolic processes such as forming the central metabolite in amino acid transamination.
CSN13419 CPPHA 693288-97-0 CPPHA is a selective positive allosteric modulator of mGluR5 receptor.
CSN18974 CFMTI 864864-17-5 CFMTI is a potent and selective metabotropic glutamate receptor (mGluR)1 allosteric antagonist with IC50 of 2.6 nM.
CSN19841 AIDA 168560-79-0 AIDA is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a), having no effect on group II (mGlu2) or group III (mGlu4) receptors expressed individually in baby hamster kidney cells.
CSN16339 ADX-47273 851881-60-2 ADX-47273 is a positive allosteric modulator of mGlu5 receptor with EC50 value of 0.23 μM in primary astrocyte culture.
CSN17040 (S)-MCPG 150145-89-4 (S)-MCPG is the active isomer of (RS)-MCPG, non-selective group I/group II metabotropic glutamate receptor antagonist.
CSN22632 (RS)-PPG 120667-15-4 (RS)-PPG is a potent and selective mGlu8 agonist.
CSN17028 (RS)-MCPG 146669-29-6 (RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist.
CSN22630 (RS)-3-Hydroxyphenylglycine 31932-87-3 (RS)-3-Hydroxyphenylglycine is a selective group I metabotropic glutamate receptor agonist.
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