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mGluR

mGluR

货号 产品名 CAS号 信息
CSN20205 VU0424238 1396337-04-4 VU0424238 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 selected for clinical evaluation of psychiatric and neurodegenerative disorders.
CSN16002 VU 0364770 61350-00-3 VU 0364770 is a brain-penetrant and positive allosteric modulator of mGlu4 receptors with EC50 values of 290 nM. It also exhibits affinity for MAO-B and MAO-A with Ki values of 0.72 μM and 8.5 μM, respectively.
CSN17179 VU 0364439 1246086-78-1 VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.
CSN15882 VU 0361737 1161205-04-4 VU 0361737 is a brain-penetrant and selective positive allosteric modulator of mGlu4 receptors with EC50 values of 240 nM.
CSN16570 VU 0357121 433967-28-3 VU 0357121 is a positive allosteric mGlu5 receptors modulator with EC50 value of 33 nM.
CSN22529 UBP 1112 339526-74-8 UBP 1112 is a selective group III mGluR antagonist, with a Kd of 5.1 μM, 96-fold affinity for group III over group II mGlu receptor (Kd, 488 μM), and shows no significant activity at group I mGlu receptor or iGlu receptor.
CSN12115 Topiramate 97240-79-4 Topiramate is a selective GluK1 kainate receptors (GluR5) antagonist with IC50 value of 0.46 μM which can act as a positive allosteric modulator of GABAA receptor-mediated currents, inhibit Nav channels and L-type Ca2+ channels.
CSN18975 Ro 67-7476 298690-60-5 Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors.
CSN15957 Ro 67-4853 302841-89-0 Ro 67-4853 is a drug used in scientific research, which acts as a selective positive allosteric modulator for the metabotropic glutamate receptor subtype mGluR1.
CSN20553 PF-06462894 1622291-66-0 PF-06462894 is an alkyne-lacking metabotropic glutamate receptor 5 negative allosteric modulator.
CSN13647 MTEP HCl 1186195-60-7 MTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist with IC50 and Ki of 5 nM and 16 nM, respectively.
CSN22469 MSOP 66515-29-5 MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR.
CSN11477 MPEP 96206-92-7 MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors.
CSN15940 MPEP HCl 219911-35-0 MPEP hydrochloride is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype with IC50 of 36 nM.
CSN18318 Methoxy-PEPy 524924-76-3 Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM.
CSN18984 Mavoglurant Racemate 1636881-61-2 Mavoglurant racemate is the racemate of mavoglurant.
CSN12419 LY404039 635318-11-5 LY404039 is an inhibitor for mGluR1 (Ki=149 nM) and mGluR2 (Ki= 92 nM), which can also inhibit dopamine receptor.
CSN18024 LY354740 176199-48-7 LY354740 is a highly potent, efficacious and selective group II (mGlu2/3) receptor agonist, produces > 90% suppression of forskolin-stimulated cAMP formation with an EC50 of 5.1 ± 0.3 nM.
CSN11347 LY341495 201943-63-7 LY341495 is a highly potent and selective group II metabotropic glutamate receptor antagonist.
CSN16643 LY2979165 1311385-32-6 LY2979165 is a mGlu2 agonist, a drug candidate drug used to treat bipolar disorder.
CSN19844 LY 456236 HCl 338736-46-2 LY 456236 hydrochloride is a selective mGlu1 receptor antagonist (IC50 values are 143 nM and > 10 μM for mGlu1 and mGlu5 receptors respectively).
CSN19861 LSN 2463359 1401031-52-4 LSN 2463359 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM).
CSN16403 L-Glutamine 56-85-9 L-Glutamine is an essential amino acid which serves as a substrate for biosynthesis of neurotransmitters glutamate and GABA in neurons.
CSN11296 L-Glutamic Acid Monosodium 142-47-2 L-Glutamic Acid Monosodium is an excitatory amino acid neurotransmitter as an agonist at GluR and NMDA receptor.
CSN22445 L-APB 23052-81-5 L-APB is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13±0.02, 0.29±0.07, 1.0±0.3, 249±107 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.
CSN19846 Kainic Acid 487-79-6 Kainic acid is a selective agonist at kainate receptors. Potent excitant and neurotoxin.
CSN18977 JNJ-16259685 409345-29-5 JNJ16259685 is a selective antagonist at the mGlu1 receptors, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM.
CSN22437 JNJ-46778212 1363281-27-9 JNJ-46778212 is an mGlu5 positive allosteric modulator with an EC50 of 260 nM.
CSN17481 JNJ-40411813 1127498-03-6 JNJ-40411813 is a positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.
CSN18792 IEM 1754 Dihydrobromide 162831-31-4 IEM 1754 dihydrobromide is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
CSN20520 GET-73 202402-01-5 GET-73 is a mGlu5 receptor allosteric modulator potentially for the treatment of alcoholism.
CSN18973 FPTQ 864863-72-9 FPTQ is mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1 respectively.
CSN10975 Evans Blue 314-13-6 Evans blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT).
CSN18512 Dipraglurant 872363-17-2 Dipraglurant is a mGluR5 antagonists with IC50 of 0.021 μM.
CSN18976 DFMTI 864864-86-8 DFMTI can completely block the rmGlu1 L757V glutamate response.
CSN13492 D-Glutamine 5959-95-5 D-Glutamine is a non-essential amino acid involved in many metabolic processes such as forming the central metabolite in amino acid transamination.
CSN16659 CTEP 871362-31-1 CTEP is a selective allosteric mGluR5 antagonist with IC50 value of 2.2 nM.
CSN13419 CPPHA 693288-97-0 CPPHA is a selective positive allosteric modulator of mGluR5 receptor.
CSN18974 CFMTI 864864-17-5 CFMTI is a potent and selective metabotropic glutamate receptor (mGluR)1 allosteric antagonist with IC50 of 2.6 nM.
CSN22354 AZD-8529 1092453-15-0 AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
CSN19841 AIDA 168560-79-0 AIDA is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a), having no effect on group II (mGlu2) or group III (mGlu4) receptors expressed individually in baby hamster kidney cells.
CSN16339 ADX-47273 851881-60-2 ADX-47273 is a positive allosteric modulator of mGlu5 receptor with EC50 value of 0.23 μM in primary astrocyte culture.
CSN17040 (S)-MCPG 150145-89-4 (S)-MCPG is the active isomer of (RS)-MCPG, non-selective group I/group II metabotropic glutamate receptor antagonist.
CSN17028 (RS)-MCPG 146669-29-6 (RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist.
CSN22629 (RS)-3,5-DHPG 146255-66-5
CSN22633 (S)-3,4-DCPG 201730-11-2
CSN22630 (RS)-3-Hydroxyphenylglycine 31932-87-3
CSN22632 (RS)-PPG 120667-15-4
CSN22634 (S)-3,5-DHPG 117468-89-0
CSN23203 YM 230888 446257-23-4
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