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mGluR
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN20205 | Auglurant | 1396337-04-4 | VU0424238 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 selected for clinical evaluation of psychiatric and neurodegenerative disorders. |
CSN16002 | VU0364770 | 61350-00-3 | VU 0364770 is a brain-penetrant and positive allosteric modulator of mGlu4 receptors with EC50 values of 290 nM. It also exhibits affinity for MAO-B and MAO-A with Ki values of 0.72 μM and 8.5 μM, respectively. |
CSN17179 | VU 0364439 | 1246086-78-1 | VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM. |
CSN16570 | VU 0357121 | 433967-28-3 | VU 0357121 is a positive allosteric mGlu5 receptors modulator with EC50 value of 33 nM. |
CSN22529 | UBP1112 | 339526-74-8 | UBP 1112 is a selective group III mGluR antagonist, with a Kd of 5.1 μM, 96-fold affinity for group III over group II mGlu receptor (Kd, 488 μM), and shows no significant activity at group I mGlu receptor or iGlu receptor. |
CSN18975 | Ro 67-7476 | 298690-60-5 | Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. |
CSN15957 | Ro 67-4853 | 302841-89-0 | Ro 67-4853 is a drug used in scientific research, which acts as a selective positive allosteric modulator for the metabotropic glutamate receptor subtype mGluR1. |
CSN20553 | PF-06462894 | 1622291-66-0 | PF-06462894 is an alkyne-lacking metabotropic glutamate receptor 5 negative allosteric modulator. |
CSN22469 | MSOP | 66515-29-5 | MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR. |
CSN18318 | Methoxy-PEPy | 524924-76-3 | Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM. |
CSN18984 | Mavoglurant racemate | 1636881-61-2 | Mavoglurant racemate is the racemate of mavoglurant. |
CSN16643 | LY2979165 | 1311385-32-6 | LY2979165 is a mGlu2 agonist, a drug candidate drug used to treat bipolar disorder. |
CSN19844 | LY456236 | 338736-46-2 | LY 456236 HCl is a selective mGlu1 receptor antagonist (IC50 values are 143 nM and > 10 μM for mGlu1 and mGlu5 receptors respectively). |
CSN19861 | LSN2463359 | 1401031-52-4 | LSN 2463359 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM). |
CSN16403 | L-Glutamine | 56-85-9 | L-Glutamine is an essential amino acid which serves as a substrate for biosynthesis of neurotransmitters glutamate and GABA in neurons. |
CSN22881 | L-CCG-I | 117857-93-9 | L-CCG-l is a potent group II metabotropic glutamate receptor agonist. |
CSN22445 | L-AP4 | 23052-81-5 | L-APB is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13±0.02, 0.29±0.07, 1.0±0.3, 249±107 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively. |
CSN18977 | JNJ16259685 | 409345-29-5 | JNJ16259685 is a selective antagonist at the mGlu1 receptors, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM. |
CSN22437 | JNJ-46778212 | 1363281-27-9 | JNJ-46778212 is an mGlu5 positive allosteric modulator with an EC50 of 260 nM. |
CSN17481 | JNJ-40411813 | 1127498-03-6 | JNJ-40411813 is a positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. |
CSN22849 | HexylHIBO | 334887-43-3 | HexylHIBO is a Group I mGlu receptor antagonist with Kis of 140 and 110 μM at mGlu1a and mGlu5a receptors respectively. |
CSN20520 | GET73 | 202402-01-5 | GET-73 is a mGlu5 receptor allosteric modulator potentially for the treatment of alcoholism. |
CSN22825 | FTIDC | 873551-53-2 | FTIDC is a potent and selective mGlu1 receptor negative allosteric modulator with IC50 of 5.8 nM. |
CSN18973 | FPTQ | 864863-72-9 | FPTQ is mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1 respectively. |
CSN22789 | 2-Amino-3-phosphonopropanoic acid | 5652-28-8 | DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase. |
CSN18512 | Dipraglurant | 872363-17-2 | Dipraglurant is a mGluR5 antagonists with IC50 of 0.021 μM. |
CSN18976 | DFMTI | 864864-86-8 | DFMTI can completely block the rmGlu1 L757V glutamate response. |
CSN16659 | CTEP | 871362-31-1 | CTEP is a selective allosteric mGluR5 antagonist with IC50 value of 2.2 nM. |
CSN22778 | CPPG | 183364-82-1 | CPPG is a potent group II/III mGlu receptor antagonist, with IC50s of 46.2 and 2.2 nM respectively. |
CSN22777 | CPCCOEt | 179067-99-3 | CPCCOEt is a hmGlu1 subtype-selective non-competitive antagonist with IC50 of 6.5 μM. |
CSN22762 | Cinnabarinic acid | 606-59-7 | Cinnabarinic Acid is a elective mGlu4 agonist. |
CSN22756 | CHPG sodium salt | 1303993-73-8 | CHPG Sodium Salt is a selective mGlu5 agonist. |
CSN22755 | CHPG | 170846-74-9 | CHPG is a selective mGlu5 metabotropic glutamate receptor agonist. |
CSN18974 | CFMTI | 864864-17-5 | CFMTI is a potent and selective metabotropic glutamate receptor (mGluR)1 allosteric antagonist with IC50 of 2.6 nM. |
CSN22354 | AZD-8529 | 1092453-15-0 | AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes. |
CSN22705 | AZD 9272 | 327056-26-8 | AZD 9272 is a potent and selective mGlu5 antagonist with IC50s of 2.6 and 7.6 nM for rat and human receptors, respectively. |
CSN22702 | AZD 2066 | 934282-55-0 | AZD 2066 is an orally bioavailable and brain penetrant mGlu5 antagonist. |
CSN19841 | UPF-523 | 168560-79-0 | AIDA is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a), having no effect on group II (mGlu2) or group III (mGlu4) receptors expressed individually in baby hamster kidney cells. |
CSN16339 | ADX-47273 | 851881-60-2 | ADX-47273 is a positive allosteric modulator of mGlu5 receptor with EC50 value of 0.23 μM in primary astrocyte culture. |
CSN22668 | rel-ACPT-I | 194918-76-8 | ACPT-I is an agonist for group III mGlu receptors with EC50 of 7.2 and 8.2 μM for mGlu4a and mGlu8 respectively. |
CSN22662 | 3-((6-Methylpyridin-2-yl)ethynyl)cyclohex-2-en-1-one O-methyl oxime | 924298-51-1 | ABP 688 is a high affinity human mGlu5 receptor antagonist with Ki of 1.7 nM. |
CSN22650 | 3-MATIDA | 518357-51-2 | 3-MATIDA is a potent metabotropic glutamate mGlu1 receptor antagonist with IC50 of 6.3 μM at rat mGlu1a. |
CSN17040 | (S)-MCPG | 150145-89-4 | (S)-MCPG is the active isomer of (RS)-MCPG, non-selective group I/group II metabotropic glutamate receptor antagonist. |
CSN22637 | (S)-HexylHIBO | 334887-48-8 | (S)-HexylHIBO is a Group I mGlu receptor antagonist with Kb of 30 and 61 μM at mGlu1a and mGlu5a receptors respectively. |
CSN22634 | (R)-2-Amino-2-(3,5-dihydroxyphenyl)acetic acid | 117468-89-0 | (S)-3,5-DHPG is a selective group I mGlu receptor agonist. |
CSN22633 | (S)-3,4-DCPG | 201730-11-2 | (S)-3,4-DCPG is a potent, selective mGlu8a agonist with EC50 of 31 nM. |
CSN22632 | (RS)-PPG | 120667-15-4 | (RS)-PPG is a potent and selective mGlu8 agonist. |
CSN17028 | (RS)-MCPG | 146669-29-6 | (RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist. |
CSN22630 | (Rac)-3-Hydroxyphenylglycine | 31932-87-3 | (RS)-3-Hydroxyphenylglycine is a selective group I metabotropic glutamate receptor agonist. |
CSN22629 | DHPG | 146255-66-5 | (RS)-3,5-DHPG is a selective group I metabotropic glutamate receptor agonist which activates both mGlu1 and mGlu5. |