欢迎来到 CSNpharm! 产品仅用于科研!
首页 400-920-2911

DHFR

DHFR

货号 产品名 CAS号 信息
CSN16458 Trimethoprim 738-70-5 Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR) which is necessary for the synthesis of purines, amino acids, and thymidylic acid, with prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively). Trimethoprim is used mainly in the prophylaxis and treatment of urinary tract infections.
CSN12806 Pyrimethamine 58-14-0 Pyrimethamine inhibits multidrug and toxin extrusion (MATE) transporter potently, it also inhibits dihydrofolate reductase (DHFR), used for protozoal infections and interferes with tetrahydrofolic acid synthesis from folic acid.
CSN13592 Pralatrexate 146464-95-1 Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines.
CSN11667 Pemetrexed 137281-23-3 Pemetrexed is an antifolate and antimetabolite for TS(thymidylate synthase), DHFR(dihydrofolate reductase) and GARFT(glycinamide ribonucleotide formyltransferase) with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
CSN16714 Pemetrexed Disodium 150399-23-8 Pemetrexed Disodium is an antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
CSN12796 Pemetrexed Disodium Hydrate 357166-30-4 Pemetrexed disodium is an antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
CSN16844 Methotrexate 59-05-2 Methotrexate, an antifolate compound, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH and can interfere with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.
CSN22453 LY309887 127228-54-0 LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 6.5 nM, and has antitumor activity.
CSN22451 LY 222306 154446-98-7 LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM.
CSN12983 Levomefolic Acid 31690-09-2 Levomefolic acid is the natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.
CSN12982 Levomefolate Calcium 151533-22-1 Levomefolate Calcium is an artificial form of folate.
CSN12564 Calcium Folinate 1492-18-8 Leucovorin calcium is a reduced form of folic acid.
CSN10090 Folinic Acid 58-05-9 Folinic acid is an adjuvant used in cancer chemotherapy involving the drug methotrexate.
CSN11049 Folinic Acid Calcium Pentahydrate 6035-45-6 Folinic acid is a reduced folic acid, which is used in combination with other chemotherapy drugs.
CSN21604 Diaveridine 5355-16-8 Diaveridine is a dihydrofolate reductase (DHFR) inhibitor with Ki of 11.5 nM, also an antibacterial agent.
CSN23284 Diaveridine HCl 2507-23-5 Diaveridine HCl is a coccidiostat and inhibits dihydrofolate reductase. It can prevente folic acid synthesis in species of Pneumocystis. Diaveridine also has genotoxicity.
CSN23377 Cycloguanil HCl 152-53-4 Cycloguanil HCl is hydrochloride form of cycloguanil which is a metabolite of proguanil and a dihydrofolate reductase inhibitor.
CSN12746 Calcium N5-methyltetrahydrofolate 26560-38-3 Calcium N5-methyltetrahydrofolate is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers.
CSN10527 Calcium Levofolinate 80433-71-2 Calcium levofolinate is the calcium salt of levoleucovorin, which is the enantiomerically active form of folinic acid.
CSN22341 AG 2037 446022-33-9 AG 2037 (Pelitrexol) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT).
<< PREV 1 NEXT >>