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DHFR

DHFR

货号 产品名 CAS号 信息
CSN16458 Trimethoprim 738-70-5 Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR) which is necessary for the synthesis of purines, amino acids, and thymidylic acid, with prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively). Trimethoprim is used mainly in the prophylaxis and treatment of urinary tract infections.
CSN12806 Pyrimethamine 58-14-0 Pyrimethamine inhibits multidrug and toxin extrusion (MATE) transporter potently, it also inhibits dihydrofolate reductase (DHFR), used for protozoal infections and interferes with tetrahydrofolic acid synthesis from folic acid.
CSN11667 Pemetrexed   137281-23-3 Pemetrexed is an antifolate and antimetabolite for TS(thymidylate synthase), DHFR(dihydrofolate reductase) and GARFT(glycinamide ribonucleotide formyltransferase) with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
CSN16714 Pemetrexed Disodium 150399-23-8 Pemetrexed Disodium is an antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
CSN16844 Methotrexate 59-05-2 Methotrexate, an antifolate compound, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH and can interfere with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.
CSN12564 Calcium Folinate 1492-18-8 Leucovorin calcium is a reduced form of folic acid.
CSN11049 Folinic Acid Calcium Pentahydrate 6035-45-6 Folinic acid is a reduced folic acid, which is used in combination with other chemotherapy drugs.
CSN21604 Diaveridine 5355-16-8 Diaveridine is a dihydrofolate reductase (DHFR) inhibitor with Ki of 11.5 nM, also an antibacterial agent.
CSN23284 Diaveridine HCl 2507-23-5 Diaveridine HCl is a coccidiostat and inhibits dihydrofolate reductase. It can prevente folic acid synthesis in species of Pneumocystis. Diaveridine also has genotoxicity.
CSN23377 Cycloguanil HCl 152-53-4 Cycloguanil HCl is HCl form of cycloguanil which is a metabolite of proguanil and a dihydrofolate reductase inhibitor.
CSN12746 Calcium N5-methyltetrahydrofolate 26560-38-3 Calcium N5-methyltetrahydrofolate is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers.
CSN10527 Calcium Levofolinate 80433-71-2 Calcium levofolinate is the calcium salt of levoleucovorin, which is the enantiomerically active form of folinic acid.
CSN26146 1-(4-Chlorophenyl)biguanide HCl 4022-81-5 1-(4-Chlorophenyl)biguanide is a guanide derivative that can inhibit dihydrofolate reductase (DHFR).
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