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Triterpenoids

Triterpenoids

货号 产品名 CAS号 信息
CSN13665 Taraxerol 127-22-0 Taraxerol, a natural product isolated and purified from the herb of Taraxacum mongolicum Hand.
CSN11974 Squalene 7683-64-9 Squalene is originally obtained from shark liver oil.
CSN19972 Shionone 10376-48-4 Shionone, a natural product isolated and purified from the flower of Chrysanthemum morifolium, has anti-inflammatory effect, the mechanism is related to decrease the phosphorylation level of ERK1/2 protein and IκBα and the protein expression of i NOS, and can inhibit the activity of ubiquitin-specific protease 2 (USP2) and provide a lead compound for future development of USP2 inhibitors.
CSN19875 Saikosaponin D 20874-52-6 Saikosaponin D, a natural product isolated and purified from the herb of Bupleurum chinense DC., is a SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity and a potent inhibitor on acute hepatic injury by CCl4 and a potent cytotoxicity agent for human hepatocellular carcinoma cells, and has the antiproliferative effect in A549 cells that may be the induction of p53 and activity of the Fas/FasL apoptotic system.
CSN19875 Saikosaponin D 20874-52-6 Saikosaponin D, a natural product isolated and purified from the herb of Bupleurum chinense DC., is a SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity and a potent inhibitor on acute hepatic injury by CCl4 and a potent cytotoxicity agent for human hepatocellular carcinoma cells, and has the antiproliferative effect in A549 cells that may be the induction of p53 and activity of the Fas/FasL apoptotic system.
CSN16187 Saikosaponin A 20736-09-8 Saikosaponin A, a natural product isolated and purified from the root of Bupleurum chinense DC., with antioxidant activity, has an inhibitory activity against allergic asthma and an anti-inflammatory activity by inhibiting the MAPK and NF-κB pathways in LPS-stimulated RAW 264.7 cells, shows the most potent cytotoxicity against human cancer cells, and is an inhibitory for cell growth and DNA synthesis with 50-μg/mL.
CSN13793 Pristimerin 1258-84-0 Pristimerin is a natural product isolated and purified from the herb of Tripterygium wilfordii Hook.f.
CSN13793 Pristimerin 1258-84-0 Pristimerin is a natural product isolated and purified from the herb of Tripterygium wilfordii Hook.f.
CSN19974 Polygalasaponin F 882664-74-6 Polygalasaponin F, a natural product isolated and purified from the herbs of Polygala japonica Houtt.
CSN19927 Polygalacin D 66663-91-0 Polygalacin D, a natural product isolated and purified from the roots of Polygala tenuifolia Willd, can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxic effect on RAW 264.7 macrophages, suppress induction by LPS of pro-inflammatory cytokines such as prostaglandin E2 (PGE2), exhibit significant inhibition on the proliferation of five kinds of cultured human tumor cell lines, i.
CSN19455 Panaxadiol 19666-76-3 Panaxadiol, a natural product isolated and purified from the roots of Panax ginseng C.
CSN15253 Notoginsenoside Ft1 155683-00-4 Notoginsenoside Ft1, a natural saponin isolated and purified from the roots of Panax notoginseng, may accelerate diabetic wound healing by orchestrating multiple processes, including promoting fibroblast proliferation, enhancing angiogenesis, and attenuating inflammatory response, which provided a great potential application of it in clinics for patients with diabetic foot ulcers, arrest the proliferation and elicited the apoptosis of SH-SY5Y cells possibly via p38 MAPK and ERK1/2 pathways, which indicates the potential therapeutic effect of it on human neuroblastoma, activate both glucocorticoid and estrogen receptors to induce endothelium-dependent, nitric oxide-mediated relaxations in rat mesenteric arteries, and enhance platelet aggregation by activating a signalling network mediated through P2Y12 receptors.
CSN14513 Moronic Acid 6713-27-5 Moronic acid, a natural product isolated and purified from the herbs of Rhus chinensis, shows oral therapeutic efficacy in HSV-infected mice and possessed anti-HSV activity, and inhibits the capacity of Rta to activate a promoter that contains an Rta-response element, indicating that Moronic acid interferes with the function of Rta.
CSN25401 Lanosterol 79-63-0 Lanosterol is a key triterpenoid intermediate in the biosynthesis of Cholesterol.
CSN20363 Kuguacin J 1141453-65-7 Kuguacin J is a natural product isolated from bitter melon leaves, and modulates paclitaxel sensitivity in drug-resistant human ovarian cancer cells.
CSN16399 Jujuboside A 55466-04-1 Jujuboside A, a natural product isolated and purified from the seeds of Zizyphus jujuba with neurophysiological inhibitory effects, performs its specific sedative and hypnotic effect through not only adjusting GABA receptors subunit mRNAs expression, but also down-regulating the secretion of relevant inflammation cytokines on the intestinal mucosal system to affect the intercellular cytokine network between nerve cells in the brain and may serve as a potential therapeutic agent for the treatment of Alzheimer׳s disease.
CSN20598 Hyperforin 11079-53-1 Hyperforin, a pharmacologically active component of the medicinal plant Hypericum perforatum (St. John's wort), has been shown to be neuroprotective against acute ischemic stroke.
CSN19980 Gypsogenin-3-O-β-D-Glucuronide Methyl Ester 96553-02-5 Gypsogenin 3-O-beta-D-glucuronopyranoside, a natural product isolated and purified from the seeds of Momordica cochinchinensis, shows inhibitory activity toward pancreatic lipase with IC50 value of 0.29 mM, and the free carboxylic acid groups in position 28 within its chemical structures are required for enhancement of pancreatic lipase inhibition.
CSN18438 Gynostemma Extract 80321-63-7 Gynostemma extract, a natural product isolated and purified from the herb of Gynostemma pentaphyllum (Thunb.) Makino., induces apoptosis in human hepatoma cells through the up-regulation of Bax and Bak, and down-regulation of Bcl-2, release of mitochondrial cytochrome c and activation of caspase cascade, induces ER stress and production of reactive oxygen species and Ca 2+ , changes the ratio of Bcl-2 and Bax, followed by the dysfunction of mitochondria, and causes cytochrome c release, activation of caspase-3 before leading to apoptosis.
CSN15613 Guajadial 959860-49-2 Guajadial is a natural product isolated and purified from the leaves Psidium guajava, reduces tumor growth and stimulate uterus proliferation, suggest that they may act as Selective Estrogen Receptors Modulators (SERMs), therefore holding significant potential for anticancer therapy, shows α-glucosidase inhibitory activities significantly and its activity was better than that of Acarbose, and exhibits potent inhibitory effects on the growth of human hepatoma cells.
CSN15613 Guajadial 959860-49-2 Guajadial is a natural product isolated and purified from the leaves Psidium guajava, reduces tumor growth and stimulate uterus proliferation, suggest that they may act as Selective Estrogen Receptors Modulators (SERMs), therefore holding significant potential for anticancer therapy, shows α-glucosidase inhibitory activities significantly and its activity was better than that of Acarbose, and exhibits potent inhibitory effects on the growth of human hepatoma cells.
CSN14085 Glutinol Acetate 6426-44-4 Glutinol acetate, a natural product isolated and purified from the stems and leaves of Acer mandshuricum., shows significant cytotoxic activity against four human cancer cell lines (HL-60, SK-OV-3, A549, and HT-29), with GI(50) in the range of 11.1-17.9 mM.
CSN14497 Glochidiol 6610-56-6 Glochidiol, a natural product isolated and purified from the herbs of Glochidion puberum L., exhibits strong inhibitory effects against all three human tumor cell lines (MCF-7, NCI-H-460 and SF-268) and exerts its antiproliferative activity through the involvement of apoptosis.
CSN17434 Ginsenoside Rh3 105558-26-7 Ginsenoside Rh3, a natural product isolated and purified from the roots of Panax ginseng C.
CSN17434 Ginsenoside Rh3 105558-26-7 Ginsenoside Rh3, a natural product isolated and purified from the roots of Panax ginseng C.
CSN19469 Ginsenoside Rh2 78214-33-2 Ginsenoside Rh2, a natural product isolated and purified from the roots of Panax ginseng C.
CSN19469 Ginsenoside Rh2 78214-33-2 Ginsenoside Rh2, a natural product isolated and purified from the roots of Panax ginseng C.
CSN19481 Ginsenoside Rg1 22427-39-0 Ginsenoside Rg1, a natural product isolated and purified from the roots of Panax ginseng C. A. Mey., is a functional ligand of glucocorticoid receptor(GR) that can boost the production of insulin receptors, stimulates the creation of new blood vessels and wound healing, relaxes and widens blood vessels and lowers blood pressure, and is a potent phytoestrogen with estrogen-like activity.
CSN15653 Ginsenoside CK 39262-14-1 Ginsenoside CK, a natural product isolated and purified from the roots of Panax ginseng C.A.Mey., is a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A.
CSN15653 Ginsenoside CK 39262-14-1 Ginsenoside CK, a natural product isolated and purified from the roots of Panax ginseng C.A.Mey., is a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A.
CSN15235 Ganoderol A 104700-97-2 Ganoderol A, a natural product isolated and purified from the fruiting body of Ganoderma lucidum, has significant anti-inflammatory activity and protection against UVA damage, thus suggesting that the compound is a candidate for the development of a suitable product to protect skin from UV-induced photoaging.
CSN14969 Ganodermanontriol 106518-63-2 Ganodermanontrio, a natural product isolated and purified from the fruit body of Ganoderma lucidum, suppresses growth of colon cancer cells through ß-catenin signaling, has hepatoprotective effect against t -BHP-induced oxidative stress in vitro and in vivo, induces in vitro and in vivo anti-inflammatory activity in t -BHP-damaged hepatic cells through the expression of HO-1, is active as anti-HIV-1 agents with an inhibitory concentration of 7.8 mg ml-1 for both, and shows antioxidative activities in a dose dependent manner and a strong anticomplement activity against the classical pathway (CP) of the complement system with IC(50) values of 17.2 mM.
CSN15234 Ganoderic Acid DM 173075-45-1 Ganoderic acid DM, a natural product isolated and purified from the fruit body of Ganoderma lucida, effectively inhibits cell proliferation and colony formation in MCF-7 human breast cancer cells, which is much stronger than that of MDA-MB-231 breast cancer cells, and is also an antiandrogenic osteoclastogenesis inhibitor.
CSN14493 Euscaphic Acid 53155-25-2 Euscaphic acid, a natural product isolated and purified from the dried fruit of Ziziphus jujuba, with anti-diabetic and anti-inflammatory activities, induces death by activation of caspase-3, dependent apoptotic pathway, and inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of IKK and MAPKs signal transduction to downregulate NF-κB activations.
CSN19895 Esculentoside A 65497-07-6 Esculentoside A, a natural product isolated and purified from the roots of Phytolacca acinosa Roxb with anti-infalmmatory activity, may be useful for the treatment of autoimmune disease through modulation on T cell-mediated adaptive immunity, play significant roles in the treatment of BXSB mice through modulation of inflammatory cytokines, inhibition of renal cell proliferation and induction of apoptosis, and suppress inflammatory responses in LPS-induced ALI through inhibition of the nuclear factor kappa B and mitogen activated protein kinase signaling pathways.
CSN15678 Epifriedelanol 16844-71-6 Epifriedelanol, a natural product isolated and purified from the herbs of Vitis trifolia with antitumor activity, exhibits significant inhibition of NF-kappa B, it may be used to treat asthma, and suppresses adriamycin-induced cellular senescence as well as replicative senescence in human fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs), suggesting that it can reduce cellular senescence in human primary cells and may be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases.
CSN15239 Dammarenediol II 14351-29-2 Dammarenediol II, a natural product isolated and purified from the roots of Panax ginseng C.A.Mey., can inhibit vascular endothelial growth factor (VEGF)-induced intracellular reactive oxygen species generation and stress fiber formation and vascular endothelial-cadherin disruption, suggesting that the natural drug dammarenediol II may have the ability to prevent diabetic microvascular complications, including diabetic retinopathy.
CSN13550 Cucurbitacin IIb 50298-90-3 Cucurbitacin IIb is a natural product isolated and purified from the rhizomes of Hemsleya amabilis Diels.
CSN15642 beta-Amyrin Acetate 1616-93-9 beta-Amyrin acetrate, a natural cannabinoid receptor isolated and purified from the herbs of Alstonia boone, shows significant HMG-CoA-reductase and sEH inhibitory activities.
CSN19994 Ainidiol 6750-30-7 Arnidiol, a natural product isolated and purified from the herbs of Tussilago farfara with anti-inflammatory activity, shows inhibitory effects against Epstein-Barr virus early antigen (EBV-EA) activation with potencies either comparable with or stronger than that of glycyrrhetic acid, a known natural anti-tumor-promoter.
CSN19991 Alisol B Acetate 19865-76-0 Alisol B acetate, a natural product isolated and purified from the tubers of Alisma plantago-aquatica Linn., can induce Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells, the Bax activation and translocation from the cytosol to nucleus might be a crucial response to the apoptotic effect.
CSN16996 Actein 18642-44-9 Actein, a natural product isolated and purified from the roots of Cimicifuga racemosa with stimulatory effect on osteoblastic bone formation and potential activity against osteoporosis, has been shown to inhibit the proliferation of human breast cancer cells, by altering the activity of the ER IP3 receptor and Na,K-ATPase, inducing calcium release and modulating the NF-κB and MEK pathways, and reduces free fatty acid and cholesterol content in the liver by 0.6-fold at 24 h and inhibites the growth of human HepG2 liver cancer cells.
CSN19986 Artemitin 1362-42-1 Absinthiin is a weak HIV-1 protease inhibitor isolated and purified from the herbs of Artemisia absinthium.
CSN15242 3alpha-Akebonoic Acid 104777-61-9 3alpha-Akebonoic acid, a natural product isolated and purified from the herbs of Akebia trifoliata, shows interesting in vitro growth inhibitory activity against human tumor A549 and HeLa cell lines and significant in vitro α-glucosidase inhibitory activity.
CSN15242 3alpha-Akebonoic Acid 104777-61-9 3alpha-Akebonoic acid, a natural product isolated and purified from the herbs of Akebia trifoliata, shows interesting in vitro growth inhibitory activity against human tumor A549 and HeLa cell lines and significant in vitro α-glucosidase inhibitory activity.
CSN15244 3-O-trans-p-Coumaroyltormentic Acid 121064-78-6 3-O-trans-p-Coumaroyltormentic acid, a natural product isolated and purified from the leaves of Eriobotrya japonica calli, induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition, and may be promising lead compound for developing an effective drug for treatment of leukemia.
CSN20327 27-Deoxyactein 264624-38-6 27-Deoxyactein, a natural product isolated and purified from Actaea racemosa, has shown stimulation of osteoblast function and inhibits bone resorbing mediators in the treatment of osteoporosis. It is a derivative of actein, a gamma secretase modulators derived from botanicals. It can also protect the pancreatic β-cells against MG-induced cell death.
CSN20339 22-Oxosaikosaponin D N/A 22-Oxosaikosaponin D is isolated and purfied from Bupleurum chinense with an agonistic activity on 5-hydroxytryptamine 2C receptor and is potential use for the treatment of obesity.
CSN19877 20(R)-Ginsenoside Rg3 38243-03-7 20(R)-Ginsenoside Rg3, a natural product isolated and purified from the roots of Panax ginseng C.
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