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P450

P450

货号 产品名 CAS号 信息
CSN17762 VT-464 Racemate 1375603-36-3 VT-464 racemate is the racemate form of VT-464, which is a potent CYP17 lyase inhibitor (h-Lyase IC50=69 nM)inhibition.
CSN19052 VT-464 R-Enantiomer 1375603-38-5 VT-464 R-enantiomer is the R-enantiomer with unknown activity of VT-464, which is a potent CYP17 lyase inhibitor (h-Lyase IC50=69 nM).
CSN12213 Voriconazole 137234-62-9 Voriconazole is a second-generation triazole antifungal used to treat serious fungal infections by inhibiting the synthesis of ergosterol, the major sterol of the fungal cell membrane.
CSN12100 TMS 24144-92-1 TMS is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).
CSN12728 TAK-700 426219-18-3 TAK-700 is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits > 1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4).
CSN11915 Seratrodast 112665-43-7 Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist.
CSN11894 Saperconazole 110588-57-3 Saperconazole is a broad-spectrum antifungal triazole and has potent activity against Aspergillus with an MIC90 of 0.19 mg/L.
CSN19933 Rhodionin 85571-15-9 Rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administered drugs.
CSN19400 Ramatroban 116649-85-5 Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis.
CSN11771 Proadifen HCl 62-68-0 Proadifen HCl is a nonspecific cytochrome P450 inhibitor, it's also a noncompetitive inhibitor of acetylcholine nicotinic receptors with IC50 of 19 μM in mouse skeletal muscle.
CSN11753 Posaconazole 171228-49-2 Posaconazole is a broad-spectrum triazole antifungi, it inhibits the growth of fungi by inhibiting the lanosterol 14α-demethylase enzyme, which results in a disruption the synthesis of ergosterol, a key sterol necessary for fungal cell membrane integrity and for the function of certain membrane-bound proteins.
CSN19175 PF-4981517 1390637-82-7 PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM, exhibits > 500-fold selectivity over CYP3A5 and CYP3A7.
CSN11643 Ozagrel Sodium 130952-46-4 Ozagrel sodium salt is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.
CSN16785 Ozagrel HCl 78712-43-3 Ozagrel HCl is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.
CSN20004 Oteseconazole 1340593-59-0 Oteseconazole is a tetrazole antifungal agent potentially for the treatment of candidal vaginal infection by inhibiting sterol 14α-demethylase (CYP51).
CSN18337 Orteronel 566939-85-3 Orteronel is a highly selective inhibitor of human 17,20-lyase with IC50 of 38 nM, and exhibits > 1000-fold selectivity over other CYPs such as 11-hydroxylase and CYP3A4.
CSN25582 NVP-VID-400 174262-13-6 NVP-VID-400 is an inhibitor of both CYP51 and CYP24A1.
CSN25221 NTP42 2055599-51-2 NTP42 is a TxA2 Synthetase antagonist with IC50 value of 3.278nM.
CSN16614 Naringin   10236-47-2 Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.
CSN11433 Metyrapone 54-36-4 Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.
CSN12625 Methoxsalen 298-81-7 Methoxsalen is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juice/fruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. It is a potent suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight.
CSN16342 Memantine HCl 41100-52-1 Memantine HCl, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively, is used for the treatment of Alzheimer's disease.
CSN27390 Mefentrifluconazole 1417782-03-6 Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent. Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM).
CSN16776 Ketoconazole   65277-42-1 Ketoconazole is an imidazole anti-fungal agent which inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively.
CSN13003 Itraconazole 84625-61-6 Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent.
CSN11218 Isbogrel 89667-40-3 Isbogrel, a ω-pyridylalkenoic acid derivative, is a thromboxane A2 synthetase inhibitor that also shows thromboxane A2 antagonism.
CSN20292 HET0016 339068-25-6 HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms.
CSN12387 Galaterone 851983-85-2 Galeterone is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth.
CSN13053 Fluconazole 86386-73-4 Fluconazole, an inhibitor of CYP2C19, CYP2C9 and CYP3A4, is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
CSN27199 DMU2105 1031063-36-1 DMU2105 is a potent CYP1B1 inhibitor with IC50 value of 10nM for human CYP1B1 enzyme bound to yeast-derived microsomes (Sacchrosomes™).
CSN10830 Diosmetin 520-34-3 Diosmetin is a bioflavonoid found in spearmint, oregano, and many other plants, and is an agonist of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity.
CSN25347 Dazoxiben HCl 74226-22-5 Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots.
CSN17441 Dafadine-A 1065506-69-5 Dafadine-A, an analog of dafadine, is an inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans and also inhibits the mammalian ortholog of DAF-9 (CYP27A1).
CSN20275 CYP11B1 Inhibitor C25 2101952-78-5 CYP11B1 inhibitor C25 is a CYP11B1 inhibitor of pyridylmethyl isoxazole type with improved pharmacological profile for the treatment of Cushing’s disease.
CSN15806 Cobicistat 1004316-88-4 Cobicistat is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.
CSN10660 Clarithromycin 81103-11-9 Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor.
CSN13101 Chlorzoxazone 95-25-0 Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It is also a CYP2E1 inhibitor with IC50 value of 1.03μM.
CSN19045 CDD3506 197913-15-8 CDD3506 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepaticcytochrome P450IIIA (CYP3A)activity.
CSN19044 CDD3505 173865-33-3 CDD3505 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepaticcytochrome P450IIIA (CYP3A)activity.
CSN18701 Carbosulfan 55285-14-8 Carbosulfan inhibits relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers).
CSN10419 Bergaptol 486-60-2 Bergaptol is a hydroxylated psoralen isolated and purified from the root of Notopterygium incisum that acts as a potent inhibitor of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 μM.
CSN16313 Benzbromarone 3562-84-3 Benzbromarone is a CYP2C9 inhibitor with Ki of 19.3 nM.
CSN17375 Baicalein 491-67-8 Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.
CSN12255 Apigenin 520-36-5 Apigenin is a potent P450 inhibitor for CYP2C9 with Ki of 2 μM, it's a natural product isolated and purified from the root of Scutellaria indica L..
CSN12322 Abiraterone 154229-19-3 Abiraterone is a potent CYP17A1 inhibitor with IC50 of 4 nM.
CSN12966 Abiraterone Acetate 154229-18-2 Abiraterone Acetate is a potent CYP17A1 inhibitor with IC50 of 4 nM.
CSN26155 6-Aminochrysene 2642-98-0 6-aminochrysene was a potent inducer of CYP1A1 in rat.
CSN26147 5-Aminomethyl-3-(pyridin-3-yl)isoxazole 543713-43-5 5-Aminomethyl-3-(pyridin-3-yl)isoxazole
CSN19374 3-Cyano-7-Ethoxycoumarin 117620-77-6 3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage.
CSN19771 25R-Inokosterone 19682-38-3 25R-Inokosterone has a role on cytochrome P450 from a hormone-resistant cell line.
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