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VEGFR

VEGFR

货号 产品名 CAS号 信息
CSN18068 ZM323881 HCl 193000-39-4 ZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor with IC50 of < 2 nM, almost no activity on VEGFR1, PDGFRβ, FGFR1, EGFR and ErbB2.
CSN16611 ZM323881 193001-14-8 ZZM 323881 is a potent and selective VEGFR2 inhibitor with IC50 of < 2 nM, exhibiting almost no activity on VEGFR1, PDGFRβ, FGFR1, EGFR and ErbB2.
CSN15826 ZM306416 690206-97-4 ZM-306416 is an inhibitor of VEGFR (Flk-1 or KDR) and Flt with IC50 of 100 nM and 2 μM.
CSN20194 α-Cembrenediol 57605-80-8 VEGFR inhibitor TC1 acts in angiogenesis inhibitory in multiple breast cancer cell lines by significantly reducing the activated VEGFR2 levels.
CSN16730 Vatalanib 212141-54-3 Vatalanib is an inhibitor of VEGFR2/KDR with IC50 of 37 nM, showing less potent against VEGFR1/Flt-1, 18-fold against VEGFR3/Flt-4.
CSN12454 Vatalanib 2HCl 212141-51-0 Vatalanib dihydrochloride is inhibitor of VEGFR2 or KDR with IC50 of 37 nM.
CSN12186 Vandetanib 443913-73-3 Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM.
CSN18225 Vandetanib Trifluoroacetate 338992-53-3 Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM.
CSN18317 Vandetanib HCl 524722-52-9 Vandetanib hydrochloride specially inhibits VEGFR2 with IC50 of 40 nM.
CSN12667 Tivozanib 475108-18-0 Tivozanib is an inhibitor of VEGFR1, VEGFR2 and VEGFR3 with IC50s of 30 nM, 6.5 nM, 15 nM, respectively. It can also inhibit PDGFR and c-Kit.
CSN17394 TG 100801 HCl 1018069-81-2 TG 100801 is the prodrug of TG 100572, which is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM or VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively.
CSN12041 Telatinib 332012-40-5 Telatinib is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRα with IC50 of 6 nM/4 nM, 1 nM and 15 nM, respectively.
CSN15808 SU5416 204005-46-9 SU5416 is a selective VEGFR2 (Flk-1/KDR) inhibitor with IC50 of 1.23 μM.
CSN12658 SU5402 215543-92-3 SU5402 is potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor.
CSN19810 SU14813 452105-23-6 SU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), KIT, and fms-like tyrosine kinase 3 (FLT-3)
CSN17169 SKLB1002 1225451-84-2 SKLB1002 is a selective inhibitor of VEGFR2 with IC50 of 32 nM.
CSN15794 Z-Semaxanib 194413-58-6 Semaxanib is an inhibitor of VEGFR2 (namely Flk-1 or KDR) with IC50 of 1.23 μM.
CSN17331 Regorafenib Monohydrate 1019206-88-2 Regorafenib is a multi-target inhibitor. It can inhibit the activities of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 and their IC50 values ​​range from 1.5 nM to 46 nM.
CSN17185 Regorafenib HCl 835621-07-3 Regorafenib hydrochloride can inhibit many kinases including RET (IC50 = 1.5 nM), Raf-1 (IC50 = 2.5 nM), VEGFR2 (IC50 = 4.2 nM), VEGFR1 (IC50 = 13 nM), PDGFRβ (IC50 = 22 nM) and VEGFR3 (IC50 = 46 nM).
CSN16062 RAF265 927880-90-8 RAF265 is a pan-inhibitor that inhibits C-Raf, B-Raf and B-Raf V600E with IC50 of 3 nM-60 nM. It also shows inhibition on phosphorylation of VEGFR2 with EC50 of 30 nM.
CSN18523 R1530 882531-87-5 R1530 is the multikinase inhibitor with potential antiangiogenesis and antineoplastic activities.
CSN12340 Pazopanib 444731-52-6 Pazopanib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.
CSN13729 Pazopanib HCl 635702-64-6 Pazopanib hydrochloride is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively.
CSN11151 Oglufanide 38101-59-6 Oglufanide is inhibitor of vascular endothelial growth factor (VEGF) that suppresses angiogenesis.
CSN12341 BIBF 1120 656247-17-5 Nintedanib is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM.
CSN18236 N-Desethyl Sunitinib 356068-97-8 N-desethyl sunitinib is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively).
CSN12691 Motesanib 453562-69-1 Motesanib is an ATP-competitive inhibitor of VEGFR1 (IC50 = 2 nM), VEGFR2 (IC50 = 3 nM), VEGFR3 (IC50 = 6 nM) and Kit.
CSN17192 Motesanib Diphosphate 857876-30-3 Motesanib diphosphate is ATP-competitive inhibitor of VEGFR1, VEGFR2 and VEGFR3 with IC50 of 2 nM, 3 nM and 6 nM, respectively. It also shows better inhibitory activity against c-Kit, PDGFR, and RET.
CSN13151 MGCD-265 875337-44-3 MGCD-265, an ATP-competitive inhibitor, can inhibit c-Met and VEGFR1, 2, 3 with IC50s of 1 nM and 3 nM, 3 nM, 4 nM, respectively. It also exhibits inhibition of Ron and Tie2.
CSN15974 Lenvatinib 417716-92-8 Lenvatinib is a multi-target inhibitor, mostly for VEGFR2 (KDR)/VEGFR3 (Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold selective for VEGFR2/3 against FGFR1, PDGFRα/β.
CSN15848 KRN-633 286370-15-8 KRN-633 can inhibit VEGFR1, VEGFR2 and VEGFR3 with IC50 of 170 nM, 160 nM, and 125 nM, respectively.
CSN17193 Ki8751 228559-41-9 Ki8751 is a selective VEGFR2 inhibitor with IC50 of 0.9 nM.
CSN17542 Fruquintinib 1194506-26-7 Fruquintinib is an inhibitor of VEGFR family with IC50s of 33 nM, 35 nM and 0.5 nM for VEGFR1, 2, 3 respectively.
CSN17568 EG00229 1210945-69-9 EG00229 is the first small molecule inhibitor of the neuropilin-1 and VEGF-A interaction with an IC50 of inhibition of 8 μM(125I-VEGF binding to PAE/NRP1 cells).
CSN17438 E-3810 1058137-23-7 E-3810 is a dual inhibitor of the VEGF and FGF receptors, potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 with IC50 of 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively.
CSN13440 CP-547632 252003-65-9 CP-547632 is a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50 11 and 9 nM, respectively). It is selective relative to epidermal growth factor receptor, platelet-derived growth factor, and other related TKs. It also inhibits VEGF-stimulated autophosphorylation of VEGFR-2 in a whole cell assay with an IC50 value of 6 nM.
CSN17311 Cediranib Maleate 857036-77-2 Cediranib maleate is a highly potent VEGFR (KDR) inhibitor with IC50 of < 1 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM, similar activity against c-Kit and PDGFRβ, 36-, 110-fold and > 1000-fold selective more for VEGFR than PDGFR-α, CSF-1R and Flt3.
CSN16877 Cabozantinib Malate 1140909-48-3 Cabozantinib S-malate is a VEGFR2 inhibitor with IC50 of 0.035 nM. It also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM-11.3 nM.
CSN15710 Cabozantinib     849217-68-1 Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.
CSN12669 Brivanib 649735-46-6 Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but > 240-fold against PDGFR-β.
CSN13568 Brivanib Alaninate 649735-63-7 Brivanib alaninate is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but > 240-fold against PDGFR-β.
CSN18663 BMS-817378 1174161-69-3 BMS-798433 shows greater than 50% TGI for at least one tumor doubling time with no toxicity observed during 14 days in GTL-16 human gastric tumor xenografts model.
CSN16881 BIBF 1120 Esylate 656247-18-6 BIBF 1120 esylate is a multiple receptor tyrosine kinases inhibitors for VEGFR1/2/3, PDGFRα/β and FGFR1/2/3 with IC50 of 34 nM/13 nM/13 nM, 59 nM/65 nM and 69 nM/37 nM/108 nM.
CSN19151 BFH772 890128-81-1 BFH772 selectively targets VEGFR2 kinase with IC50 of 3 nM.
CSN19152 BAW2881 861875-60-7 BAW2881 is an inhibitor of vascular endothelial growth factor (VEGF) with IC50s of 1.0 nM-4.3 nM against VEGFR1, 2, 3 and also inhibits PDGFRβ, c-Kit, and RET.
CSN10361 Axitinib 319460-85-0 Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively.
CSN17579 Apatinib Mesylate 1218779-75-9 Apatinib is a VEGFR2 inhibitor with IC50 of 1 nM and also can suppress the activities of Ret (IC50 = 13 nM), c-Kit (IC50 = 429 nM) and c-Src (IC50 = 530 nM).
CSN13818 Apatinib 811803-05-1 Apatinib is a selective inhibitor of VEGFR2 with IC50 of 1 nM.
CSN23877 Acrizanib   1229453-99-9 Acrizanib is a selective VEGFR2 inhibitor with IC50 value of 17.4nM.
CSN16990 2,4-Pyrimidinediamine with Linker 1430089-64-7 2,4-Pyrimidinediamine with linker is a multikinase inhibitor with a -NH2 terminal linker.
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