||Defactinib is a potent FAK phosphorylation inhibitor and overcomes YB-1–mediated paclitaxel resistance by an AKT-dependent pathway.
||S63845 specifically binds with high affinity to the BH3-binding groove of MCL1. S63845 potently kills MCL1-dependent cancer cells, including multiple
||SSR240612 is a potent and selective non-peptide bradykinin B1 receptor antagonist with Kis of 0.48 nM and 0.73 nM for B1 kinin receptors of human fibr
||GLPG1690, a first-in-class autotaxin (ATX) inhibitor with IC50 of 131 nM and Ki of 15 nMl, is able to cause a sustained reduction of LPA levels in pla
||CM4620 is a CRAC channel inhibitor to treat acute pancreatitis.
||AZD0364 is an ERK1 and/or ERK2 kinase for the treatment of cancer.
||GSK484 is a reversible and selective inhibitor of PAD4 with IC50 of 50 nM. GSK484 blocks the citrullination of PAD4 target proteins in human neutrophi
||SEW2871 is a potent and selective sphingosine-1-phosphate 1 (S1P1) receptor agonist. Activates S1P1 receptor with an EC50 of 13 nM, but does not activ
||AMG-3969 is a glucokinase-GKRP disruptor with IC50 value of 343nM and potently reverses the inhibitory effect of GKRP on GK activity.
||AZ3451 is a protease-activated receptor-2 (PAR2) antagonist.
||PF-4136309 is a potent, Selective, and orally bioavailable CCR2 antagonist.
||AZD 5069 is a selective and reversible antagonist of CXCR2 that can inhibit CXCL8 binding to CXCR2 with pIC50 of 9.1.
||ASK1-IN-1 is an apoptosis signal regulating kinase 1 (ASK1) inhibitor.
||AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities.
||SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 pr
||Tat-NR2B9c is a PSD95 inhibitor with EC50 of 7 nM, also inhibit p38.
||AMZ30 is a selective, covalent inhibitors of protein phosphatase methylesterase-1 (PME-1; IC50=600 nM), and selectively inactivates PME-1 and reduces
||PF-05089771 is a Nav1.7 channel blocker with an IC50 of 8.6 nM.
||TAPI-1 is a specific TACE (TNF-α-converting enzyme) inhibitor.
||LY 3000328 is a highly selective and potent Cathepsin S inhibitor with IC50 of 7.7±5.85 nM and 1.67±1.17 nM for hCat S and mCat S respectively, can be
||MK-1064 is a selective orexin 2 receptor antagonist(2-SORA) for the research of insomnia.
||Icatibant is a selective and specific antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.
||GNE-3511 is a potent and selective zipper kinase (DLK, MAP3K12) inhibitors.
||UNC0224 is a selective inhibitor of G9a with IC50 of 15 nM.
||JNJ-17203212 is a selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1.
||AM095 Free Acid
||AM095 free acid is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
||7ACC2 is a potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx for antitumor treatment targeting lactate transport in cance
||AR-C155858 is an inhibitor of the monocarboxylate transporters (MCTs) MCT1 and MCT2 (Ki values are 2.3 and < 10 nM, respectively), and exhibits no act
||SAR405 is highly potent and selective inhibitor of PIK3C3 with an IC50 of 27 nM.
||Pentostatin can inhibit adenosine deaminase irreversibly with Ki of 2.5 pM, as an antineoplastic anti-metabolite used in the treatment of several form
||JC-1 is a cyanine dye that has been used to determine mitochondrial transmembrane potential.
||GLX351322 is an inhibitor of NADPH oxidase 4, inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μ M.
||Potent and selective TRPA1 antagonist (IC50 = 0.02 μM for human TRPA1). Exhibits no siginificant activity against human TRPV1 or TRPV4, and rat TRPV1,
||Semaglutide is an analog of human GLP-1 with long-acting effect over the other GLP-1Ras.
||UVI 3003 is a potent and selective RXR antagonist, used as a tool to test the contribution of RXR to transactivation by a given RXR heterodimer.
||LOXO-195 is a TRK kinase inhibitor (TKI) with IC50 values of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively.
||Ningetinib tosylate is an inhibitor of tyrosine kinase inhibitor (TKI) and the IC50 for c-Met, VEGFR2 and Axl are 6.7 nM, 1.9 nM and <1.0 nM respectiv
||BB-Cl-amidine is a irreversible peptidylarginine deminase (PAD) inhibitor.
||BIBF0775 is an inhibitor of transforming growth factor β receptor I (TGFβRI) by soaking into the kinase domain of TGFβRI.
||Retro-2 is a specific retrograde trafficking inhibitor of protein toxins.
||DL-800 is an allosteric and selective SIRT6 activator with EC50 of 10.3μM.
||Acrizanib is a selective VEGFR2 inhibitor with IC50 value of 17.4nM.
||RK-287107 is a novel tankyrase-specific inhibitor with IC50 values of 14.3 nM and 10.6 nM for tankyrase-1 and tankyrase-2, respectively.
||TUG-1375 is a free fatty acid receptor 2 (FFA2/GPR43) inhibitor with pKi of 6.69.