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PAK

PAK

货号 产品名 CAS号 信息
CSN17173 PF-3758309 898044-15-0 PF-3758309 is an inhbitor of PAKs with IC50 of 1.3 nM for PAK4, which inhbits tumor growth in HCT116, A549, M24met and other xenograft tumor models.
CSN17983 KPT-9274 1643913-93-2 PAK4-IN-1 is an inhibitor of p21-activated kinases (PAKs), with IC50 of ≤100 nM in MTT assay.
CSN20017 NVS-PAK1-1 1783816-74-9 NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay.
CSN18267 IPA-3 42521-82-4 IPA-3 is a selective non-ATP competitive PAK1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).
CSN17987 G-5555 1648863-90-4 G-5555 is a selective PAK1 inhibitor (Ki=3.7 nM).
CSN15824 FRAX597 1286739-19-2 FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM).
CSN17596 FRAX486 1232030-35-1 FRAX486 is a selective inhibitor of group I PAKs with IC50s of 8.25/39.5, /55.3 nM for PAK1/PAK2/PAK3 respectivelt and less potent for PAK4 (IC50=779 nM).
CSN17853 FRAX1036 1432908-05-8 FRAX-1036 is a potent and selective PAK1 inhibitor.
CSN18571 APTO-253 916151-99-0 APTO-253 is a small molecule with potent anti-tumor activity in cancer cells via induction of the gene that expresses the Kruppel-like factor 4 (KLF4) master transcription factor, leading to cell cycle inhibition and programmed cell death.
CSN15508 Alpiniaterpene A 1448667-05-7 Alpiniaterpene A is a p21-activated kinase 1 (PAK1) inhibitors isolated from different parts of alpinia zerumbethas has a hair growth promoting and anticancer effects.
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