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Endothelin Receptor

Endothelin Receptor

货号 产品名 CAS号 信息
CSN13675 Zibotentan 186497-07-4 Zibotentan is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM).
CSN12014 Sulfisoxazole 127-69-5 Sulfisoxazole is an antagonist of endothelin receptor that can be used as a sulfonamide antibacterial agent.
CSN11008 Sodium Ferulate 24276-84-4 Sodium ferulate is the sodium salt of ferulic acid which is used for the treatment of cardiovascular disease.
CSN12974 Sitaxsentan Sodium 210421-74-2 Sitaxsentan sodium has selectory antagonism of endothelin A (ETA) receptor with the IC50 and Ki value of 1.4 nM and 0.43 nM respectively.
CSN12975 Sitaxsentan 184036-34-8 Sitaxsentan is a selective endothelin A (ETA) receptor antagonist.
CSN17902 Ro 46-2005 150725-87-4 Ro 46-2005 is an antagonist of endothelin receptor.
CSN18333 Macitentan N-Butyl Analogue 556797-16-1 Macitentan n-butyl analogue is a n-butyl analogue of Macitentan (ACT064992), which is an orally active, non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
CSN13736 Macitentan 441798-33-0 Macitentan is an antagonist of endothelin receptor A (ETA) with IC50 of 0.5 nM. It is developed for treatment of pulmonary arterial hypertension (PAH).
CSN22138 J-104132 198279-45-7 J-104132 is a potent, orally active ETA/ETB receptor antagonist, with Kis of 0.034 nM and 0.104 nM for cloned human ETA and ETB receptors expressed in CHO cells.
CSN20320 HJP272 1072467-37-8 HJP272, an endothelin receptor antagonist, attenuates lipopolysaccharide-induced acute lung injury.
CSN23533 Darusentan 171714-84-4 Darusentan is an antagonist of endothelin ETA receptor and it can be used to treat congestive heart failure and hypertension.
CSN19760 Clazosentan 180384-56-9 Clazosentan is a potent endothelin A antagonist, improves cerebral blood flow and behavior after traumatic brain injury.
CSN17348 BQ-788 Sodium 156161-89-6 BQ-788 sodium salt is a potent, selective ETB receptor antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC50 of 1300 nM.
CSN18010 BQ-788 173326-37-9 BQ-788 is a potent and selective endothelin receptor subtype B (ETB) antagonist with IC50 of 1.2 nM (inhibits 125I-labeled endothelin 1 (ET-1) binding to ETB receptors on human Girardi heart cells).
CSN17753 BQ-123 136553-81-6 BQ-123 is a specific antagonist of endothelin A receptor (ETA) and the IC50 is 7.3 nM.
CSN10481 Bosentan Hydrate 157212-55-0 Bosentan is an endothelin (ET) receptor antagonist of ET-A (Ki = 4.7 nM) and ET-B (Ki = 95 nM).
CSN10480 Bosentan 147536-97-8 Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.
CSN12872 Avosentan 290815-26-8 Avosentan is a potent, selective endothelin receptor (ETA receptor) antagonist.
CSN18015 Atrasentan 173937-91-2 Atrasentan is an endothelin receptor antagonist (IC50=0.0551 nM, ETA) being developed for the treatment of prostate cancer.
CSN13753 Atrasentan HCl 195733-43-8 Atrasentan hydrochloride is an endothelin receptor antagonist (IC50=0.0551 nM, ETA) being developed for the treatment of prostate cancer.
CSN10496 Ambrisentan 177036-94-1 Ambrisentan is an oral, once-daily endothelin receptor antagonist that is selective for the endothelin type A receptor (IC50s = 0.251, 0.316, 0.398, 251, and 630 nM for rat preparations of heart, bladder, kidney, lung, and cerebral cortex, respectively).
CSN17466 ACT-132577 1103522-45-7 ACT-132577 is the major and pharmacologically active metabolite of macitentan), which is dual ETA/ETB endothelin (ET) receptor antagonist designed for tissue targeting.
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