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DNA/RNA Synthesis

DNA/RNA Synthesis

货号 产品名 CAS号 信息
CSN10257 α-Amanitin 23109-05-9 α-Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II.
CSN16911 YK-4-279 1037184-44-3 YK 4-279 is a potent inhibitor of RNA Helicase A (RHA) that binding to the oncogenic transciption factor EWS-FLI1.
CSN12159 Tubercidin 69-33-0 Tubercidin, obtained from Streptomyces tubercidicus, is an adenosine analogue, is a nucleoside antibiotic. Also exhibits antifungal and antiviral activities.
CSN13562 Triapine 143621-35-6 Triapine is a ribonucleotide reductase inhibitor and a CDK inhibtor.
CSN15880 Tosufloxacin Tosylate 115964-29-9 Tosufloxacin tosylate is an antibacterial agent that inhibits bacterial DNA gyrase inhibitor.
CSN12039 Tegafur 17902-23-7 Tegafur is a prodrug of 5-fluorouraci 5-FU, is used in the treatment of cancers.
CSN21983 Lonsurf 733030-01-8 TAS-102 is an oral combination drug consisting of trifluridine (FTD), which is a thymidine-based nucleoside analog, and tipiracil HCl (TPI), which improves the bioavailability of FTD by inhibiting its catabolism by thymidine phosphorylase (TP).
CSN15712 Sofosbuvir 1190307-88-0 Sofosbuvir is an investigational nucleotide analog and a HCV NS5B polymerase inhibitor for treatment of chronic HCV infection.
CSN15756 SCR7 1533426-72-0 SCR7 is an inhibitor of DNA Ligase IV, it inhibits joining of DSBs in cell-free repair system and inhibits NHEJ (nonhomologous end-joining) in a Ligase IV-dependent manner within cells, and activates the intrinsic apoptotic pathway.
CSN11845 Rifaximin 80621-81-4 Rifaximin is an RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria.
CSN11844 Rifapentine 61379-65-5 Rifapentine is an antibiotic compound, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis.
CSN16146 Rifampicin 13292-46-1 Rifampicin is a bacterial RNA polymerase inhibitor used in the treatment of bacterial infections.
CSN19455 Panaxadiol 19666-76-3 Panaxadiol, a natural product isolated and purified from the roots of Panax ginseng C.
CSN11595 Oxolinic Acid 14698-29-4 Oxolinic acid is a potent inhibitor of DNA gyrase and DNA synthesis, lead to DNA cleavage when extracted chromosomes are incubated with sodium dodecyl sulfate.
CSN16103 Nelarabine 121032-29-9 Nelarabine is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
CSN11454 Mizoribine 50924-49-7 Mizoribine is an immunosuppressive agents (IC50=100 μM) that inhibit the proliferation of lymphocytes selectively, via inhibition of IMPDH.
CSN15759 L189 64232-83-3 L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 μM.
CSN16113 Hydroxyurea 127-07-1 Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
CSN11136 Halofuginone 55837-20-2 Halofuginone is an inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/mL in mammal.
CSN11086 Gemcitabine 95058-81-4 Gemcitabine is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.
CSN16647 Gemcitabine HCl 122111-03-9 Gemcitabine HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.
CSN10050 Folic Acid 59-30-3 Folic acid, a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.
CSN10528 Fludarabine 21679-14-1 Fludarabine, a DNA synthesis inhibitor, is a chemotherapy drug used in the treatment of hematological malignancies.
CSN16461 Fludarabine Phosphate 75607-67-9 Fludarabine phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
CSN12666 Favipiravir 259793-96-9 Favipiravir is an anti-viral compound with activity against many RNA viruses and an RNA-directed RNA polymerase NS5B inhibitor.
CSN14493 Euscaphic Acid 53155-25-2 Euscaphic acid, a natural product isolated and purified from the dried fruit of Ziziphus jujuba, with anti-diabetic and anti-inflammatory activities, induces death by activation of caspase-3, dependent apoptotic pathway, and inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of IKK and MAPKs signal transduction to downregulate NF-κB activations.
CSN10149 Difloxacin 98106-17-3 Difloxacin is a quinolone antimicrobial antibiotic and an inhibitor of Topo II which may reverse drug resistance in human neuroblastoma cells.
CSN16684 Daptomycin 103060-53-3 Daptomycin is a lipopeptide antimicrobial agent with activity against Gram-positive organisms, including multi-resistant strains.
CSN10080 Dacarbazine 4342-03-4 Dacarbazine is an antineoplastic agent with significant activity against melanomas, by acting as an alkylating agent and inhibiting DNA synthesis as a purine analog
CSN17133 CX-5461 1138549-36-6 CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM.
CSN10693 Cordycepin 73-03-0 Cordycepin is a nucleoside adenosine derivative that acts as an anticancer and antifungal agent. Cordycepin inhibits growth of various tumor cells in vitro. It can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Cordycepin is also useful for the study of messenger RNA transcription.
CSN16701 Clofarabine 123318-82-1 Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
CSN10636 Cidofovir 113852-37-2 Cidofovir is an anti-CMV drug which can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription.
CSN12631 Chlorambucil 305-03-3 Chlorambucil is mainly used in the treatment of chronic lymphocytic leukemia.
CSN10592 Cefuroxime 55268-75-2 Cefuroxime is a second-generation variety of cephalosporins with less susceptibility to beta-lactamase.
CSN10587 Ceftiofur HCl 103980-44-5 Ceftiofur HCl is a cephalosporin antibiotic used to treat both Gram-positive and Gram-negative bacteria infection.
CSN10584 Cefquinome Sulfate 118443-89-3 Cefquinome Sulfate is an antibacterial used in the treatment of infections caused by pathogens such as S. aureus, E. coli, Streptococcus, P. multocida and A. pleuropneumoniae.
CSN10553 Carmofur 61422-45-5 Carmofur is an antimetabolite used as an antineoplastic agent, it's a derivative of fluorouracil.
CSN16176 Capecitabine 154361-50-9 Capecitabine is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU, and used as an anti-cancer prodrug.
CSN10472 Bleomycin Sulfate 9041-93-4 Bleomycin sulfate is a glycopeptide antitumor antibiotic produced by the bacterium S. verticillus. It functions by breaking single- and double-strand DNA in tumor cells and interrupts the cell cycle.
CSN10073 Blasticidin S HCl 3513-03-9 Blasticidin S inhibits protein synthesis by acting on the step of peptide transfer from peptidyl-sRNA to incoming aminoacyl-sRNA.
CSN10391 Bendamustine HCl 3543-75-7 Bendamustine HCl is a DNA-damaging agent with IC50 of 50 μM.
CSN16813 Beaucage Reagent 66304-01-6 Beaucage Reagent is potent in causing DNA cleavage.
CSN16282 BCX 4430 Free Base 249503-25-1 BCX 4430 free base is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and demonstrates broad-spectrum activity in multiple viruses and a favorable preliminary preclinical safety profile.
CSN12561 8-Hydroxyquinoline 148-24-3 8-Hydroxyquinoline inhibits RNA synthesis and acts as a fungicide against Trichophyton mentagrophytes, Myrothecium verrucaria and Trichoderma viride, it's also a monoprotic bidentate chelating agent and dye.
CSN10160 6-Thio-dG 789-61-7 6-Thio-dG is a nucleoside analog and telomerase substrate.
CSN12836 6-Mercaptopurine Monohydrate 6112-76-1 6-Mercaptopurine Monohydrate inhibits the de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA, it is a widely used antileukemic agent and immunosuppressive drug.
CSN16373 6-Mercaptopurine 50-44-2 6-Mercaptopurine inhibits the de novo purine synthesis through interference with DNA and RNA synthesis, it's an immunosuppressive and antileukemic drug.
CSN10139 6-Azuridine 54-25-1 6-Azauridine is a synthetic triazine analog of uridine with antimetabolite activity. 6-Azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis.
CSN23335 5-methoxyflavone 42079-78-7 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors.
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