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DNA/RNA Synthesis

DNA/RNA Synthesis

货号 产品名 CAS号 信息
CSN16911 YK-4-279 1037184-44-3 YK 4-279 is a potent inhibitor of RNA Helicase A (RHA) that binding to the oncogenic transciption factor EWS-FLI1.
CSN16802 Vidarabine 5536-17-4 Vidarabine is an antiviral drug effects by interfering with the synthesis of viral DNA, which is used in treatment of herpes simplex and varicella zoster viruses.
CSN12159 Tubercidin 69-33-0 Tubercidin, obtained from Streptomyces tubercidicus, is an adenosine analogue, is a nucleoside antibiotic. Also exhibits antifungal and antiviral activities.
CSN13562 Triapine 143621-35-6 Triapine is a ribonucleotide reductase inhibitor and a CDK inhibtor.
CSN15880 Tosufloxacin Tosylate 115964-29-9 Tosufloxacin tosylate is an antibacterial agent that inhibits bacterial DNA gyrase inhibitor.
CSN12039 Tegafur 17902-23-7 Tegafur is a prodrug of 5-fluorouraci 5-FU, is used in the treatment of cancers.
CSN15712 Sofosbuvir 1190307-88-0 Sofosbuvir is an investigational nucleotide analog and a HCV NS5B polymerase inhibitor for treatment of chronic HCV infection.
CSN15758 SCR7 Pyrazine   14892-97-8 SCR7 pyrazine is a specific DNA ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ).
CSN15756 SCR7 1533426-72-0 SCR7 is an inhibitor of DNA Ligase IV, it inhibits joining of DSBs in cell-free repair system and inhibits NHEJ (nonhomologous end-joining) in a Ligase IV-dependent manner within cells, and activates the intrinsic apoptotic pathway.
CSN11845 Rifaximin 80621-81-4 Rifaximin is an RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria.
CSN11844 Rifapentine 61379-65-5 Rifapentine is an antibiotic compound, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis.
CSN16146 Rifampicin 13292-46-1 Rifampin is a bacterial RNA polymerase inhibitor used in the treatment of bacterial infections.
CSN11595 Oxolinic Acid 14698-29-4 Oxolinic acid is a potent inhibitor of DNA gyrase and DNA synthesis, lead to DNA cleavage when extracted chromosomes are incubated with sodium dodecyl sulfate.
CSN16103 Nelarabine 121032-29-9 Nelarabine is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
CSN11454 Mizoribine   50924-49-7 Mizoribine is an immunosuppressive agents (IC50=100 μM) that inhibit the proliferation of lymphocytes selectively, via inhibition of IMPDH.
CSN15759 L189 64232-83-3 L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 μM.
CSN16113 Hydroxyurea 127-07-1 Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
CSN11136 Halofuginone 55837-20-2 Halofuginone is an inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/mL in mammal.
CSN11086 Gemcitabine 95058-81-4 Gemcitabine is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.
CSN16647 Gemcitabine HCl 122111-03-9 Gemcitabine hydrochloride is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.
CSN10050 Folic Acid 59-30-3 Folic acid, a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.
CSN10528 Fludarabine   21679-14-1 Fludarabine, a DNA synthesis inhibitor, is a chemotherapy drug used in the treatment of hematological malignancies.
CSN16461 Fludarabine Phosphate 75607-67-9 Fludarabine phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
CSN17043 Fidaxomicin 873857-62-6 Fidaxomicin is a macrocyclic antibiotic drug that inhibits RNA polymerase sigma subunit, and shows selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.
CSN12666 Favipiravir 259793-96-9 Favipiravir is an anti-viral compound with activity against many RNA viruses and an RNA-directed RNA polymerase NS5B inhibitor.
CSN10149 Difloxacin 98106-17-3 Difloxacin is a quinolone antimicrobial antibiotic and an inhibitor of Topo II which may reverse drug resistance in human neuroblastoma cells.
CSN16684 Daptomycin 103060-53-3 Daptomycin is a lipopeptide antimicrobial agent with activity against Gram-positive organisms, including multi-resistant strains.
CSN10080 Dacarbazine 4342-03-4 Dacarbazine is an antineoplastic agent with significant activity against melanomas, by acting as an alkylating agent and inhibiting DNA synthesis as a purine analog
CSN10693 Cordycepin 73-03-0 Cordycepin is a nucleoside adenosine derivative that acts as an anticancer and antifungal agent. Cordycepin inhibits growth of various tumor cells in vitro. It can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Cordycepin is also useful for the study of messenger RNA transcription.
CSN10636 Cidofovir 113852-37-2 Cidofovir is an anti-CMV drug which can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription.
CSN12631 Chlorambucil 305-03-3 Chlorambucil is mainly used in the treatment of chronic lymphocytic leukemia.
CSN10592 Cefuroxime 55268-75-2 Cefuroxime is a second-generation variety of cephalosporins with less susceptibility to beta-lactamase.
CSN10587 Ceftiofur HCl 103980-44-5 Ceftiofur HCl is a cephalosporin antibiotic used to treat both Gram-positive and Gram-negative bacteria infection.
CSN10584 Cefquinome Sulfate 118443-89-3 Cefquinome Sulfate is an antibacterial used in the treatment of infections caused by pathogens such as S. aureus, E. coli, Streptococcus, P. multocida and A. pleuropneumoniae.
CSN10553 Carmofur 61422-45-5 Carmofur is an antimetabolite used as an antineoplastic agent, it's a derivative of fluorouracil.
CSN16176 Capecitabine 154361-50-9 Capecitabine is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU, and used as an anti-cancer prodrug.
CSN12816 Bromodeoxyuridine 59-14-3 Bromodeoxyuridine is a thymidine analogue which is incorporated into DNA.
CSN16976 BMH-21 896705-16-1 BMH-21 is a DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and does not cause phosphorylation of H2AX.
CSN10472 Bleomycin Sulfate 9041-93-4 Bleomycin sulfate is a glycopeptide antitumor antibiotic produced by the bacterium S. verticillus. It functions by breaking single- and double-strand DNA in tumor cells and interrupts the cell cycle.
CSN10391 Bendamustine HCl 3543-75-7 Bendamustine HCl is a DNA-damaging agent with IC50 of 50 μM.
CSN16813 Beaucage Reagent 66304-01-6 Beaucage Reagent is potent in causing DNA cleavage.
CSN16282 BCX 4430 Free Base 249503-25-1 BCX 4430 free base is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and demonstrates broad-spectrum activity in multiple viruses and a favorable preliminary preclinical safety profile.
CSN10257 α-Amanitin 23109-05-9 alpha-Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II.
CSN12561 8-Hydroxyquinoline 148-24-3 8-Hydroxyquinoline inhibits RNA synthesis and acts as a fungicide against Trichophyton mentagrophytes, Myrothecium verrucaria and Trichoderma viride, it's also a monoprotic bidentate chelating agent and dye.
CSN10160 6-Thio-dG 789-61-7 6-Thio-dG is a nucleoside analog and telomerase substrate.
CSN16373 6-Mercaptopurine 50-44-2 6-Mercaptopurine inhibits the de novo purine synthesis through interference with DNA and RNA synthesis, it's an immunosuppressive and antileukemic drug.
CSN12836 6-Mercaptopurine Monohydrate 6112-76-1 6-Mercaptopurine inhibits the de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA, it is a widely used antileukemic agent and immunosuppressive drug.
CSN10139 6-Azuridine 54-25-1 6-Azauridine is a synthetic triazine analog of uridine with antimetabolite activity. 6-Azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis.
CSN23622 2'-deoxyuridine 951-78-0 2'-Deoxyuridine is frequently halogenated to create thymidine analogues which is useful in studies of DNA synthesis and degradation mechanisms.
CSN10073 Blasticidin S HCl 3513-03-9
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