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DNA/RNA Synthesis

DNA/RNA Synthesis

货号 产品名 CAS号 信息
CSN10257 α-Amanitin 23109-05-9 α-Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II.
CSN16911 YK-4-279 1037184-44-3 YK 4-279 is a potent inhibitor of RNA Helicase A (RHA) that binding to the oncogenic transciption factor EWS-FLI1.
CSN16802 Vidarabine 5536-17-4 Vidarabine is an antiviral drug effects by interfering with the synthesis of viral DNA, which is used in treatment of herpes simplex and varicella zoster viruses.
CSN12159 Tubercidin 69-33-0 Tubercidin, obtained from Streptomyces tubercidicus, is an adenosine analogue, is a nucleoside antibiotic. Also exhibits antifungal and antiviral activities.
CSN12039 Tegafur 17902-23-7 Tegafur is a prodrug of 5-fluorouraci 5-FU, is used in the treatment of cancers.
CSN25509 2'-Deoxy-2'-fluorouridine 784-71-4 RNA that was modified with 2'-deoxy-2'-fluorouridine yielded full length HIV-1 reverse transcription products, with complete fidelity in transcription. RNA analogue, FF, containing two molecules of 2'-deoxy-2'-alpha-fluorouridine in place of uridine efficiently inhibited the RNase L-catalyzed RNA cleavage reaction.
CSN11845 Rifaximin 80621-81-4 Rifaximin is an RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria.
CSN11844 Rifapentine 61379-65-5 Rifapentine is an antibiotic compound, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis.
CSN26441 RG7800 1449598-06-4 RG7800 HCl is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; has the potential to treat spinal muscular atrophy.
CSN19455 Panaxadiol 19666-76-3 Panaxadiol, a natural product isolated and purified from the roots of Panax ginseng C.
CSN11595 Oxolinic Acid 14698-29-4 Oxolinic acid is a potent inhibitor of DNA gyrase and DNA synthesis, lead to DNA cleavage when extracted chromosomes are incubated with sodium dodecyl sulfate.
CSN25485 N,N-Dimethylguanosine 2140-67-2 N,N-Dimethylguanosine, an urinary nucleoside, is a primary degradation product of tRNA.
CSN19748 MS444 150045-18-4 MS-444 is a chrysanthone-like compound specifically inhibit the HuR from binding ARE-RNAs.
CSN11454 Mizoribine 50924-49-7 Mizoribine is an immunosuppressive agents (IC50=100 μM) that inhibit the proliferation of lymphocytes selectively, via inhibition of IMPDH.
CSN23239 Guanosine 118-00-3 Guanosine is a purine nucleoside.
CSN25484 L-Guanosine 26578-09-6 Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. L-Guanosine is the L configuration of Guanosine.
CSN10050 Folic Acid 59-30-3 Folic acid, a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.
CSN10528 Fludarabine 21679-14-1 Fludarabine, a DNA synthesis inhibitor, is a chemotherapy drug used in the treatment of hematological malignancies.
CSN14493 Euscaphic Acid 53155-25-2 Euscaphic acid, a natural product isolated and purified from the dried fruit of Ziziphus jujuba, with anti-diabetic and anti-inflammatory activities, induces death by activation of caspase-3, dependent apoptotic pathway, and inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of IKK and MAPKs signal transduction to downregulate NF-κB activations.
CSN22052 2'-Deoxypseudouridine 39967-60-7 Deoxypseudouridine is a nucleotide analog.
CSN25243 CMLD-2 958843-91-9 CMLD-2 competitively binds to Hu antigen R with Ki value of 350nM and disrupts the interaction of HuR and ARE (adenine- and uridine-rich element) of target mRNAs.
CSN16701 Clofarabine 123318-82-1 Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
CSN12631 Chlorambucil 305-03-3 Chlorambucil is mainly used in the treatment of chronic lymphocytic leukemia.
CSN16976 BMH-21 896705-16-1 BMH-21 is a DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and does not cause phosphorylation of H2AX.
CSN10472 Bleomycin Sulfate 41432-97-7 Bleomycin sulfate is a glycopeptide antitumor antibiotic produced by the bacterium S. verticillus. It functions by breaking single- and double-strand DNA in tumor cells and interrupts the cell cycle.
CSN10073 Blasticidin S HCl 3513-03-9 Blasticidin S inhibits protein synthesis by acting on the step of peptide transfer from peptidyl-sRNA to incoming aminoacyl-sRNA.
CSN10391 Bendamustine HCl 3543-75-7 Bendamustine HCl is a DNA-damaging agent with IC50 of 50 μM.
CSN27392 AV-153 free base 19350-66-4 AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity.
CSN12561 8-Hydroxyquinoline 148-24-3 8-Hydroxyquinoline inhibits RNA synthesis and acts as a fungicide against Trichophyton mentagrophytes, Myrothecium verrucaria and Trichoderma viride, it's also a monoprotic bidentate chelating agent and dye.
CSN25488 2-Amino-8-bromo-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one 4016-63-1 8-Bromoguanosine is a brominated derivative of guanosine.
CSN25518 6-Thioguanosine 85-31-4 6-thioguanosine is photosensitive molecule that photocrosslinks to both proteins and nucleic acids.
CSN12836 6-Mercaptopurine Monohydrate 6112-76-1 6-Mercaptopurine Monohydrate inhibits the de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA, it is a widely used antileukemic agent and immunosuppressive drug. 6-mercaptopurine was found to inhibit SARS-CoV PLpro.
CSN16373 6-Mercaptopurine 50-44-2 6-Mercaptopurine inhibits the de novo purine synthesis through interference with DNA and RNA synthesis, it's an immunosuppressive and antileukemic drug. 6-mercaptopurine was found to inhibit SARS-CoV PLpro.
CSN23335 5-methoxyflavone 42079-78-7 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors.
CSN25506 5-Iododeoxycytidine 611-53-0 5-Iododeoxycytidine is used in the construction of DNA oligomers.
CSN25526 5-Iodo-cytidine 1147-23-5 5-Iodocytidine is used for research in the field of nucleic acids and nucleic acid-protein interactions.
CSN25507 5-Fluorouridine 316-46-1 5-Fluorouridine is a metabolite of 5-fluorouracil with anticancer activity and cytotoxic activity. 5-fluorouridine inhibits rRNA synthesis of human colon carcinoma cells. 5-Fluorouridine exhibits cytotoxic effect on growth of L1210 cells with an IC50 of 2 nM. 5-Fluorouridine triphosphate acted as a potent competitive inhibitor of VPg uridylylation, the initial step of viral replication.
CSN25530 5-Fluorocytidine 2341-22-2 5-Fluorocytidine could replace cytidine and be incorporated into cellular RNAs or tRNAs.The bacterial enzyme cytosine deaminase has been used as a negative selection marker system. Cells that express cytosine deaminase convert 5-fluorocytosine to the toxic compound 5-fluorouracil, and transformed seedlings can thus be identified using medium containing 5-fluorocytosine.
CSN25480 5-Ethynyluridine 69075-42-9 5-Ethynyluridine is used to help detect RNA synthesis in cells by its biosynthetic incorporation into newly transcribed RNA. Once fed to cells, it is incorporated during active RNA synthesis and can then be detected using a copper-catalyzed click reaction with fluorescent dyes. The cells can then be analysed by fluorescence imaging, flow cytometry or high content imaging analysis.
CSN25508 5-Bromouridine 957-75-5 5-Bromouridine is used to label RNA in measurement of RNA production.
CSN25531 5-Bromocytidine 3066-86-2 5-Bromocytidine is a bromine substituted nucleoside.Its β-isomer derivative is a potent anti-HIV agent.
CSN27391 3,4-Dihydroxybenzylamine hydrobromide 16290-26-9 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) is an improved dopamine analog cytotoxic and inhibits DNA polymerase activity in melanoma cells. 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity.
CSN25483 3'-O-Acetylthymidine 21090-30-2 3'-O-Acetylthymidine is a useful modified nucleoside.
CSN25481 3'-O-(TBDMS)Thymidine 40733-27-5 3'-O-(TBDMS)Thymidine is a useful modified nucleoside.
CSN25486 2-O-Methylguanosine 2140-71-8 2'-O-Methylguanosine is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase, using S-adenosyl-L-methionine as a substrate.
CSN25490 2'-O-(2-Methoxyethyl)-guanosine 473278-54-5 2'-O-(2-Methoxyethyl)-guanosine is a guanosine derivative as building blocks for cross-linking oligonucleotides.
CSN25516 2'-Deoxyadenosine 958-09-8 2'-Deoxyadenosine is a nucleoside adenosine derivative, pairing with deoxythymidine (T) in double-stranded DNA.
CSN25491 (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(6-oxo-1H-purin-9(6H)-yl)tetrahydrofuran-3,4-diyl diacetate 3181-38-2 2',3',5'-Tri-O-acetylinosine is an intermediate used for the synthesis of 6-substituted purine ribosides.
CSN25487 2-Amino-9-((2R,4R,5S)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one 22837-44-1
CSN25489 N-Isobutyrylguanosine 64350-24-9
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