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DNA/RNA Synthesis
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN24863 | ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate | 58-97-9 | Uridine 5'-monophosphate is a nucleotide that is used as a monomer in RNA. |
CSN16447 | Pyrimidine-2,4(1H,3H)-dione | 66-22-8 | Uracil is one of the four nucleobases in the nucleic acid of RNA can be used for drug delivery and as a pharmaceutical. |
CSN12504 | trans-4-(aminomethyl)cyclohexane-1-carboxylic acid | 1197-18-8 | Tranexamic acid is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM. |
CSN19417 | 4-(Aminomethyl)cyclohexanecarboxylic acid | 701-54-2 | Tranexamic Acid (Random Configuration) is a medication used to treat or prevent excessive blood loss from major trauma, surgery, tooth removal, nose bleeds, and heavy menstruation.Inducing single-and double-strand breaks in DNA, base damage, and cell death. |
CSN43681 | TK216 | 1903783-48-1 | TK-216, an analog of YK-4-279 inhibitor, is a potent and selective EWS-FLI1 inhibitor. TK-216 is in early clinical development for the treatment of Ewing sarcoma. |
CSN21982 | 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one | 18771-50-1 | Tetrahydrouridine is potent inhibitor of cytidine deaminase (CDA). |
CSN51391 | FEN1-IN-SC13 | 2098776-03-3 | SC13 specifically inhibits FEN1 activity. It suppresses cancer cell proliferation and induces chromosome instability and cytotoxicity in cells, as well as sensitizes cancer cells to DNA damage-inducing therapeutic modalities and impedes cancer progression in a mouse model. |
CSN32990 | 5-(4-(tert-Butyl)benzamido)-N-hydroxy-1H-indole-2-carboxamide | 2563874-93-9 | Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1) Inhibitors;TNF-alpha (ARE sequence)/ELAV-Like protein 1 (HuR) Interaction Inhibitors |
CSN32991 | 1-(5-(Pyridin-3-yl)-1,3,4-oxadiazol-2-yl)naphthalen-2-ol | 2247176-87-8 | Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1) Inhibitors |
CSN32994 | RRM1 Inhibitor 5 | 1271734-91-8 | Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1) Inhibitors |
CSN32992 | (S)-6-(2-(2-(1,3-Dioxoisoindolin-2-yl)acetamido)-2-methylpropanamido)-2-(4,4,4-trifluoro-3-hydroxy-3-(trifluoromethyl)butanamido)hexanoic acid | 1819992-33-0 | Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1) Inhibitors |
CSN26441 | RG7800 | 1449598-06-4 | RG7800 HCl is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; has the potential to treat spinal muscular atrophy. |
CSN17016 | (E)-5-(4-Hydroxystyryl)benzene-1,3-diol | 501-36-0 | Resveratrol is one of the numerous polyphenolic compounds found in several vegetal sources, has a wide spectrum of targets with IC50 of 0.8, 1, 3.3 and 5 μM for Adenylyl cyclase, IKKβ, DNA polymerase α and δ, respectively. |
CSN11829 | (S)-2-(5-(Methyl((2-methyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)amino)thiophene-2-carboxamido)pentanedioic acid | 112887-68-0 | Raltitrexed is an inhibitor of thymidylate synthase with IC50 of 9 nM in L1210 cell. |
CSN16448 | 7H-Furo[3,2-g]chromen-7-one | 66-97-7 | Psoralen, an ingredient from Fructus Psoraleae, intercalates with DNA, inhibiting DNA synthesis and cell division and showing anticancer activity. |
CSN21764 | Nitracrine | 4533-39-5 | Nitracrine, an acridine antineoplastic used in ovarian tumors, can inhibit RNA synthesis. |
CSN25485 | N2N2-Dimethylguanosine | 2140-67-2 | N,N-Dimethylguanosine, an urinary nucleoside, is a primary degradation product of tRNA. |
CSN19748 | MS-444 | 150045-18-4 | MS-444 is a chrysanthone-like compound specifically inhibit the HuR from binding ARE-RNAs. |
CSN43591 | Metarrestin | 1443414-10-5 | Metarrestin is a specific inhibitor of perinuclear compartment (PNC). |
CSN22455 | LysRs-IN-1 | 281676-77-5 | LysRs-IN-1 is a Lysyl-tRNA synthetase (LysRs) inhibitor. |
CSN33100 | N-(3-Cyano-1H-indol-7-yl)benzene-1,4-disulfonamide | 444579-59-3 | Indisulam analog 4, as molecular glue, is especially effective and improves the half maximal effective concentration (EC50) to 1.21 µM in recruiting RBM39 to the DCAF15–DDB1–DDA1 complex. |
CSN26246 | HAMNO | 138736-73-9 | HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions with proteins involved in the replication stress response. It has shown to significantly inhibits colony formation when combined with etoposide. |
CSN23239 | 2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one | 118-00-3 | Guanosine is a purine nucleoside. |
CSN29504 | Gemcitabine monophosphate | 116371-67-6 | Gemcitabine is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. |
CSN22052 | Deoxypseudouridine | 39967-60-7 | Deoxypseudouridine is a nucleotide analog. |
CSN16684 | 2,2'-((3S,6S,9R,15S,18R,21S,24S,30S,31R)-30-((S)-2-((R)-4-Amino-2-((S)-2-decanamido-3-(1H-indol-3-yl)propanamido)-4-oxobutanamido)-3-carboxypropanamido)-3-(2-(2-aminophenyl)-2-oxoethyl)-24-(3-aminopropyl)-6-((R)-1-carboxypropan-2-yl)-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontane-15,21-diyl)diacetic acid | 103060-53-3 | Daptomycin is a lipopeptide antimicrobial agent with activity against Gram-positive organisms, including multi-resistant strains. |
CSN24877 | Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogentriphosphate | 36051-68-0 | Cytidine 5'-triphosphate is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases. |
CSN25243 | CMLD-2 | 958843-91-9 | CMLD-2 competitively binds to Hu antigen R with Ki value of 350nM and disrupts the interaction of HuR and ARE (adenine- and uridine-rich element) of target mRNAs. |
CSN27392 | 3,5-Bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-4-carboxylic acid | 19350-66-4 | AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity. |
CSN32946 | COH-4 | 1190932-36-5 | Apoptosis Inducers; RRM2 Expression Inhibitors |
CSN32948 | COH-20 | 1190932-37-6 | Apoptosis Inducers; RRM2 Expression Inhibitors |
CSN32947 | COH1 | 20217-22-5 | Apoptosis Inducers; RRM2 Expression Inhibitors |
CSN18264 | A2AR-agonist-1 | 41552-95-8 | A2AR-agonist-1 is a potent A2AR and ENT1 agonist with Ki of 4.39 and 3.47 for A2AR and ENT1. |
CSN23866 | 8-Chloroadenosine | 34408-14-5 | 8-Chloroadenosine is a cytotoxic nucleoside analog, it can inhibit RNA synthesis. |
CSN25518 | 6-Thioguanosine | 85-31-4 | 6-thioguanosine is photosensitive molecule that photocrosslinks to both proteins and nucleic acids. |
CSN12836 | 7H-Purine-6-thiol hydrate | 6112-76-1 | 6-Mercaptopurine Monohydrate inhibits the de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA, it is a widely used antileukemic agent and immunosuppressive drug. 6-mercaptopurine was found to inhibit SARS-CoV PLpro. |
CSN16373 | 6-Mercaptopurine | 50-44-2 | 6-Mercaptopurine inhibits the de novo purine synthesis through interference with DNA and RNA synthesis, it's an immunosuppressive and antileukemic drug. 6-mercaptopurine was found to inhibit SARS-CoV PLpro. |
CSN24938 | 5-Methylcytosine | 554-01-8 | 5-Methylcytosine, a methylated form of the DNA base cytosine, is a major epigenetic mark in the nuclear DNA in mammals and may be involved in the regulation of gene transcription. |
CSN24883 | 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidin-2(1H)-one | 838-07-3 | 5-Methyl-2'-deoxycytidine (5-Me-dC) is a minor component found in most eukaryotic DNA. |
CSN25531 | 4-Amino-5-bromo-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one | 3066-86-2 | 5-Bromocytidine is a bromine substituted nucleoside.Its β-isomer derivative is a potent anti-HIV agent. |
CSN27391 | 3,4-Dihydroxybenzylamine HBr | 16290-26-9 | 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) is an improved dopamine analog cytotoxic and inhibits DNA polymerase activity in melanoma cells. 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity. |
CSN18758 | 2'-Deoxycytidine hydrochloride | 3992-42-5 | 2'-Deoxyguanosine HCl is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose. |
CSN25519 | 6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7H-purine-8(9H)-thione | 3001-45-4 | |
CSN27830 | NSAH | 1099592-35-4 | |
CSN32745 | SCR130 | 2377858-38-1 | |
CSN62426 | Nusinersen | 1258984-36-9 | |
CSN63477 | NVS-SM2 | 1562333-92-9 | |
CSN85479 | Branaplam HCl | 1562338-39-9 | |
CSN107520 | Trimidox | 95933-74-7 |