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Proteasome

Proteasome

货号 产品名 CAS号 信息
CSN17237 VR23 1624602-30-7 VR23 is a small molecule inhibitor which targets β2 of the 20S proteasome with IC50 of 1 nM and can induce apoptosis of cancer cells via cyclin E–mediated centrosome amplification.
CSN22527 TY-51469 603987-59-3 TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively.
CSN18857 TIR-199 1514925-83-7 TIR-199, a natural product-derived syrbactin structural analog which covalently binds each of the three catalytic subunits (β1, β2, and β5) and revealed key interaction sites, and is used for the treatment of multiple myeloma and other forms of cancer.
CSN22501 Rpn11-IN-1 2084867-65-0 Rpn11-IN-1 is a potent and selective inhibitor of proteasome subunit Rpn11 with an IC50 of 390 nM.
CSN22188 Proteasome-IN-1 374080-21-4 Proteasome-IN-1 is a proteasome inhibitor extracted from patent WO 2013142376 A1.
CSN15914 PI-1840 1401223-22-0 PI-1840 is a potent and selective inhibitor for chymotrypsin-like (CT-L) (IC50 value = 27 ± 0.14 nM) over trypsin-like and peptidylglutamyl peptide hydrolyzing (IC50 values > 100 μM) activities of the proteasome.
CSN18603 Oprozomib 935888-69-0 ONX 0912 is an inhibitor of proteasome that targets the chymotrypsin-like activity of the 20S proteasome subunits β5 (IC50 = 36 nM) and LMP7 (IC50 = 82 nM).
CSN17316 MLN9708 1201902-80-8 MLN9708 is the prodrug of MLN2238 which is an inhibitor of the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM, 0.93 nM, respectively.
CSN11436 MG-132 133407-82-6 MG-132 is an inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 nM).
CSN19716 Marizomib 437742-34-2 Marizomib, a natural product isolated and purified from marine bacteria Salinispora tropica and Salinispora arenicola, inhibits 20S proteasome to overcome compensatory hyperactivation in multiple myeloma and solid tumour patients.
CSN12950 Ixazomib 1072833-77-2 Ixazomib selectively inhibits the chymotrypsin-like proteolytic (β5) site of 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively.
CSN17356 Ixazomib Citrate 1239908-20-3 Ixazomib citrate is the citrate form of ixazomib which is an inhibitor of chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 of 3.4 nM.
CSN19673 GNF-6702 1799329-72-8 GNF-6702 is a proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.
CSN15770 Epoxomicin 134381-21-8 Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome.
CSN12951 Delanzomib 847499-27-8 Delanzomib is an orally active inhibitor of the chymotrypsin-like activity of proteasome with IC50 of 3.8 nM, with only marginal inhibition of the tryptic and peptidylglutamyl activities of the proteosome.
CSN22376 Clasto-Lactacystin β-lactone 154226-60-5 Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.
CSN16303 Celastrol 34157-83-0 Celastrol is an inhibitor of HSP90 with antioxidant and anti-inflammatory activities.
CSN13893 Carfilzomib 868540-17-4 Carfilzomib is an irreversible proteasome inhibitor with IC50 of < 5 nM and can treat relapsed and refractory multiple myeloma.
CSN19285 Capzimin 2084868-04-0 Capzimin shows > 5-fold selectivity for Rpn11 over the related JAMM proteases and > 2 logs selectivity over several other metalloenzymes.
CSN10115 Bortezomib 179324-69-7 Bortezomib is an inhibitor of 20S proteasome with Ki of 0.6 nM.
CSN22676 AM 114 856849-35-9
CSN22831 Gliotoxin 67-99-2
CSN15835 ONX-0914 960374-59-8
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