生物活性

• 描述Marizomib, a natural product isolated and purified from marine bacteria Salinispora tropica and Salinispora arenicola, inhibits 20S proteasome to overcome compensatory hyperactivation in multiple myeloma and solid tumour patients.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02903069	Glioblastoma ... more >>Malignant Glioma Collapse <<	Phase 1	Recruiting	May 31, 2020	United States, California ... more >> University of California, Irvine Medical Center Comprehensive Brain Tumor Program Recruiting Irvine, California, United States, 92697 Contact: Jinah Chung    714-456-8442    jinahec@uci.edu    Principal Investigator: Daniela Bota, MD, PhD          University of California, San Diego Moores Cancer Center Recruiting La Jolla, California, United States, 92037 Contact: Brian Churas    858-534-7996    bchuras@ucsd.edu    Principal Investigator: David Piccioni, MD, PhD          John Wayne Cancer Institute at the Providence Saint John's Health Center Recruiting Santa Monica, California, United States, 90404 Contact: Najee Boucher    310-582-7460    najee.boucher@providence.org    Principal Investigator: Santosh Kesari, MD, PhD          United States, Illinois Northwestern Brain Tumor Institute at Northwestern University Not yet recruiting Chicago, Illinois, United States, 60611 Contact: Anne Mendelke       anne.mendelke@northwestern.edu    Contact: Roger Stupp, MD    (855) 695-6284       United States, North Carolina Duke University Medical Center, Preston Robert Tisch Brain Tumor Center Recruiting Durham, North Carolina, United States, 27710 Contact: Sarah Woodring    919-684-2527    sarah.woodring@duke.edu    Contact: Denise Jaggers    919-613-6803    denise.jaggers@dm.duke.edu    Principal Investigator: Annick Desjardins, MD          United States, Pennsylvania Penn State Health Milton S. Hershey Medical Center Recruiting Hershey, Pennsylvania, United States, 17033 Contact: Scott Murphy    717-531-0003 ext 283114    smurphy6@pennstatehealth.psu.edu    Principal Investigator: Dawit G Aregawi, MD          Canada, Ontario Princess Margaret Hospital, Gerry and Nancy Pencer Brain Tumour Centre Recruiting Toronto, Ontario, Canada Contact: Mariya Bakalets    416-946-4603    mariya.bakalets@uhn.ca    Contact: Elena Chizhov    416-946-4624    elena.chizhov@uhn.ca    Principal Investigator: Warren Mason, MD          Switzerland University Hospital Zurich Brain Tumor Center Recruiting Zurich, Switzerland, 8091 Contact: Carola Keding    +41 44 255 55 00    carola.keding@usz.ch    Principal Investigator: Patrick Roth, MD Collapse <<
  NCT00461045	Multiple Myeloma	Phase 2	Completed	-	United States, Florida ... more >> Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, Illinois University of Chicago, School of Medicine Chicago, Illinois, United States, 60637 United States, Maryland University of Maryland Baltimore, Maryland, United States, 21201 United States, Massachusetts Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Collapse <<
  NCT02330562	Malignant Glioma ... more >> Glioblastoma Collapse <<	Phase 1	Recruiting	February 18, 2020	United States, California ... more >> Comprehensive Brain Tumor Program at the University of California, Irvine Medical Center Recruiting Irvine, California, United States, 92697 Contact: Jinah Chung    714-456-8442    jinahec@uci.edu    Principal Investigator: Daniela Bota, MD, PhD          John Wayne Cancer Institute at the Providence Saint John's Health Center Recruiting Santa Monica, California, United States, 90404 Contact: MaDonna Johnson    310-582-7364    johnsonm@jwci.org    Contact: Najee Boucher       Najee.Boucher@providence.org    Principal Investigator: Santosh Kesari, MD, PhD          United States, New York Brain Tumor Center at NewYork Presbyterian Hospital/Weill Cornell Medical Center Recruiting New York, New York, United States, 10021 Contact: Amanda DeLaurentiis    646-962-9349    amd9041@med.cornell.edu    Principal Investigator: Howard A Fine, MD          United States, North Carolina The Preston Robert Tisch Brain Tumor Center at the Duke University Medical Center Recruiting Durham, North Carolina, United States, 27710 Contact: Sarah Woodring    919-684-2527    sarah.woodring@duke.edu    Contact: Denise Jaggers    919-613-6803    denise.jaggers@dm.duke.edu    Principal Investigator: Annick Desjardins, MD          Canada, Ontario Gerry and Nancy Pencer Brain Tumour Centre at Princess Margaret Hospital Recruiting Toronto, Ontario, Canada, M5G 2M9 Contact: Stephanie Tropiano    (416) 946-4501 ext 2673    stephanie.tropiano@uhn.ca    Contact: Mariya Bakalets       mariya.bakalets@uhn.ca    Principal Investigator: Warren Mason, MD Collapse <<

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• 参考文献

• [1] Harrison SJ, Mainwaring P, et al. Phase I Clinical Trial of Marizomib(NPI-0052) in Patients with Advanced Malignancies Including Multiple Myeloma: Study NPI-0052-102 Final Results. Clin Cancer Res. 2016 Sep 15;22(18):4559-66.

  [2] Richardson PG, Zimmerman TM, et al. Phase 1 study of marizomib in relapsed or relapsed and refractory multiple myeloma: NPI-0052-101 Part 1. Blood. 2016 Jun 2;127(22):2693-700.