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c-RET
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN25546 | Selpercatinib | 2152628-33-4 | Selpercatinib is a potent and specific RET inhibitor with IC50 values of 1 nM, 2 nM, 2 nM, 4 nM, 2 nM, 2 nM for WT RET, RET V804M, RET V804L, RET A883F, RET M918T and RET S891A respectively. |
| CSN13099 | Regorafenib | 755037-03-7 | Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13/4.2/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. |
| CSN25230 | ODM-203 | 1430723-35-5 | ODM-203 is a selective inhibitor of FGFR and VEGFR with IC50 values of 11, 16, 6, 35nM for recombinant FGFR1-4 and 26, 9, 5nM for VEGFR1-3, respectively. |
| CSN23893 | LOXO-292 | 2222755-14-6 | LOXO-292 is a RET kinase inhibitor with IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively . |
| CSN18365 | AST-487 | 630124-46-8 | AST-487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM. |
| CSN22316 | AD80 | 1384071-99-1 | AD80 is a multikinase inhibitor with inhibitions on RET, RAF, SRC and S6K. |