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IDH
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN22566 | Vorasidenib | 1644545-52-7 | Vorasidenib is an isocitrate dehydrogenase (IDH) inhibitor. |
CSN17325 | Mutant IDH1-IN-2 | 1429176-69-1 | Mutant IDH1-IN-2 is an inhibitor of mutant isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in fluorescence biochemical assay. |
CSN17324 | Mutant IDH1-IN-1 | 1355326-21-4 | Mutant IDH1-IN-1 is a potent mutant IDH1 R132H inhibitor with IC50 < 0.1 μM. |
CSN17836 | Mutant IDH1 inhibitor | 1429180-08-4 | Mutant IDH1 inhibitor is a potent mutant IDH1 R132H inhibitor with IC50 of < 72 nM. |
CSN23687 | IDH-305 | 1628805-46-8 | IDH-305 is a selective inhibitor of IDH1 R132H and R132C with IC50 of 18 and 28 nM, respectively. |
CSN21984 | GSK864 | 1816331-66-4 | GSK864 is an isocitrate dehydrogenase 1 (IDH1) mutant inhibitor which inhibits IDH1 mutants R132C, R132H, and R132G with IC50 values of 8.8, 15.2 and 16.6 nM. |
CSN17069 | 2-Methyl-1-((4-(6-(trifluoromethyl)pyridin-2-yl)-6-((2-(trifluoromethyl)pyridin-4-yl)amino)-1,3,5-triazin-2-yl)amino)propan-2-ol | 1446502-11-9 | Enasidenib is a selective mutant IDH2 enzyme inhibitor with IC50 of 12 nM. |
CSN25248 | DS-1001b | 1898207-64-1 | DS-1001b is a novel selective mutant IDH1 inhibitor with antitumor activity. |
CSN10737 | D-alpha-Hydroxyglutaric Acid Disodium | 103404-90-6 | D-alpha-Hydroxyglutaric Acid Disodium is a multiple-target inhibitor of KDM4A and α-Ketoglutarate(α-KG)-dependent dioxygenase, as well as an NF-κB activator. |
CSN19688 | BAY-1436032 | 1803274-65-8 | BAY 1436032 is a potent, selective and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). |
CSN13819 | AGI-6780 | 1432660-47-3 | AGI-6780 is a selective inhibitor of IDH2/R140Q mutant with IC50 value of 23 nM, |
CSN16218 | AGI-5198 | 1355326-35-0 | AGI-5198 is a potent and selective inhibitor of IDH1 R132H and R132C mutants with IC50 values of 0.07 and 0.16 µM, respectively, but not wild-type IDH1, wild-type IDH2, or IDH2 mutants. |
CSN19720 | (2S)-N-(1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide | 1448346-63-1 | AG-120 Racemate is the racemate form of AG-120 with no activity. |
CSN17323 | (S)-N-((S)-1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide | 1448347-49-6 | AG-120 is a first-in-class mutant IDH1 inhibitor. |
CSN19057 | (R,S)-Ivosidenib | 2070009-31-1 | (R,S)-Ivosidenib is an inhibitor of isocitrate dehydrogenase (IDH1). |