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Smo

Smo

货号 产品名 CAS号 信息
CSN20315 Smo Inhibitor C24 1567963-99-8 Smo inhibitor C24 is a tetrahydropyrido[4,3-d]pyrimidine derivative that represent a set of Smo inhibitors that could potentially be utilized to treat medulloblastoma and other Hh pathway related malignancies.
CSN19210 SAG HCl 2095432-58-7 SAG HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.
CSN15911 PF-5274857 1373615-35-0 PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.
CSN13874 PF-04449913 1095173-27-5 PF-04449913 is a potent and orally bioavailable smoothened inhibitor. PF-04449913 binds to human SMO (amino acids 181-787) with an IC50 of 4 nM.
CSN23037 PF 5274857 HCl 1613439-62-5 PF 5274857 HCl is a high affinity and selective Smoothened (Smo) receptor antagonist with Ki of 4.6 nM.
CSN23031 PF 04449913 Maleate 2030410-25-2 PF 04449913 Maleate is a potent Smo antagonist with IC50 of 5 nM.
CSN18669 MK-4101 935273-79-3 MK-4101 inhibits the hedgehog pathway with anti-tumor activity via the inhibition of proliferation and induction of apoptosis.
CSN19814 LEQ506 1204975-42-7 LEQ506 is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity.
CSN17578 LDE225 Diphosphate 1218778-77-8 LDE225 diphosphate is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.
CSN15980 Jervine 469-59-0 Jervine is hedgehog signaling inhibitor with IC50 of 500 nM-700 nM that disrupts the interaction with smoothened.
CSN23089 SANT-2 329196-48-7 Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity
CSN22854 IHR 1 548779-60-8 IHR 1 is a potent Smo antagonist with IC50 of 7.6 nM.
CSN22839 GSA 10 300833-95-8 GSA 10 is a smoothened (Smo) receptor agonist with EC50 of 1.2 μM.
CSN10720 Cyclopamine   4449-51-8 Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM in TM3Hh12 cells.
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