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TLR

TLR

货号 产品名 CAS号 信息
CSN10950 Toll-like Receptor Modulator 926927-42-6 Toll-like receptor modulator is a quinazolinone-derived regulator of both Toll-like receptor and γ-secretase.
CSN20478 TLR2-IN-C29 363600-92-4 TLR2-IN-C29 is an inhibitor of TLR2.
CSN15947 TAK-242 243984-11-4 TAK-242, a small-molecule-specific inhibitor of Toll-like receptor (TLR)4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4.
CSN21096 CU-CPT22 1416324-85-0 Selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF-α and IL-1β.
CSN12798 Resiquimod 144875-48-9 Resiquimod is an agonist of TLR7 and TLR8 with antiviral and antitumoral activities.
CSN11744 Polyinosinic Acid-Polycytidylic Acid 24939-03-5 Polyinosinic acid-polycytidylic acid is a TLR3 agonist and an immunostimulant. It is used in the form of its sodium salt to simulate viral infections.
CSN22182 PF-4878691 532959-63-0 PF-4878691 is a potent and selective Toll-like receptor 7 (TLR7) agonist.
CSN15696 Motolimod 926927-61-9 Motolimod is a Toll-like receptor 8 (TLR8) agonist with EC50 of 100 nM with immunostimulatory and antineoplastic activities.
CSN19750 MEDI9197 1359993-59-1 MEDI9197 is an imidazoquinoline analogue toll-like receptor (TLR) agonist that can be used for cancer immunotherapy based on its efficacy toward a variety of tumors.
CSN21351 MD2-IN-1 111797-22-9 MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189  μM for the recombinant human MD2 (rhMD2).
CSN18539 Imiquimod Maleate 896106-16-4 Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.
CSN13134 Imiquimod 99011-02-6 Imiquimod is an agonist of toll-like receptor 7 with EC50 of 2.1 µM that has antiviral and antitumor activities. It is commonly used to treat warts and anal areas.
CSN18646 Imiquimod HCl 99011-78-6 Imiquimod hydrochloride is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.
CSN24299 IAXO-102 1115270-63-7 IAXO-102 is a novel small molecule TLR4 antagonist.
CSN20419 GSK2245035 Maleate 1325212-97-2 GSK2245035 maleate is a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties which displays extraordinary IFNα inducing potency and IFNα/TNFα selectivity.
CSN13630 GS-9620 1228585-88-3 GS-9620 is a selective agonist of Toll-like receptor 7 (TLR-7) in chimpanzees and has anti-HBV infection activity.
CSN20270 G2013 1986-15-8 G2013 is a compoudn immunomodulatory effect on TLR2 and TLR4 in human mononuclear cells.
CSN17716 E-6446 2HCl 1345675-25-3 E6446 dihydrochloride is an antagonist of TLRs and suppresses DNA stimulation in cancer cells with IC50 of 10 nM.
CSN17582 E-6446 1219925-73-1 E-6446 is a synthetic antagonist for nucleic acid-sensing TLRs and potently suppresses DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
CSN21261 CU-CPT-9a 2165340-32-7 CU-CPT9b is a selective inhibitor of TLR8 with IC50 and Kd of 0.7 nM and 21 nM.
CSN21262 CU-CPT-9b 2162962-69-6 CU-CPT9a is a selective Toll-like receptor 8 (TLR8) inhibitor with IC50 of 0.5 nM. It can also suppress TNF-α levels.
CSN20259 CU-CPT17e 2109805-75-4 CU-CPT17e is a multi-Toll-like receptor (TLR3/8/9) agonist with proinflammatory and anticancer activities.
CSN22781 CU CPT 4a 1279713-77-7 CU CPT 4a is a selective TLR3 inhibitor with IC50 of 3.44 μM in RAW 264.7 cells.
CSN22764 CL 075 256922-53-9 CL 075 is a TLR8 agonist.
CSN22734 C34 40592-88-9 C34 is a TLR4 inhibitor.
CSN22347 AN-3485 1213827-99-6 AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM.
CSN21226 CU-CPT-8m 125079-83-6
CSN22794 DSR 6434 1059070-10-8
CSN23072 RS 09 1449566-36-2
CSN23121 SM 324405 677773-91-0
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