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p38 MAPK

p38 MAPK

货号 产品名 CAS号 信息
CSN16728 VX-745 209410-46-8 VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.
CSN16018 VX-702 745833-23-2 VX-702 is a highly selective inhibitor of p38α MAPK with IC50 of 4 -20 nM.
CSN21102 UM-164 903564-48-7 UM-164 is a potent dual c-Src/p38 kinase inhibitor that exhibits potent anti-TNBC activity in xenograft models. UM-164 inhibits p38 kinase and binds to an inactive c-Src conformation.
CSN15958 TAK-715 303162-79-0 TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, being 28-fold selective for p38α over p38β, showing no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.
CSN18029 TA-02 1784751-19-4 TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.
CSN13149 SKF-86002 72873-74-6 SKF-86002 is a potent inhibitor of p38 MAP kinase with IC50 of 0.5-1 μM and inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM).
CSN17172 Skepinone-L 1221485-83-1 Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
CSN18176 SD-06 271576-80-8 SD-06 is a p38 MAP kinase inhibitor and inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats(83% inhibition at 1mg/kg, po).
CSN16503 Scopoletin 92-61-5 Scopoletin has important anti-inflammatory activity by inhibiting the phosphorylation of NF-κB and p38 MAPK.
CSN18198 SCIO-469 309913-83-5 SCIO-469 is a selective ATP-competitive p38 inhibitor with IC50 of 9 nM for p38α in vitro, about 10-fold selectivity for p38α over p38β, and at least 2000-fold selectivity for p38α over an in vitro panel of 20 other kinases, including other MAK kinases.
CSN13746 SB-242235 193746-75-7 SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 μM.
CSN11899 SB-203580   152121-47-6 SB-203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM.
CSN18506 SB-203580 HCl 869185-85-3 SB-203580 hydrochloride is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM.
CSN12267 SB-202190 152121-30-7 SB-202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase with IC50 values of 50 nM and 100 nM for p38α and p38β respectively; also shows slightly weaker activity for BRD4 (Kd=3.4 μM).
CSN12897 SB-239063 193551-21-2 SB 239063 is a potent, selective and oral active p38 MAPK inhibitor with IC50 of 44 nM for recombinant purified p38α.
CSN18788 R1487 HCl 449808-64-4 R1487 hydrochloride is highly potent and highly selective inhibitors of p38α.
CSN13463 PH-797804 586379-66-0 PH-797804 is a pyridinone inhibitor of p38α with IC50 of 26 nM, being 4-fold selective versus p38β and does not inhibit JNK2.
CSN19212 Pexmetinib 945614-12-0 Pexmetinib is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line.
CSN13817 PD169316 152121-53-4 PD169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 = 89 nM).
CSN19013 Pamapimod 449811-01-2 Pamapimod is a selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 mM, respectively with no activity against p38delta or p38gamma isoforms.
CSN17386 p38 MAPK-IN-1 1006378-90-0 p38 MAPK-IN-1 is a potent and selective inhibitor of p38 MAPK with IC50 of 68 nM, shows sustained levels, low clearance and good bioavailability.
CSN20238 NJK14047 1800576-41-3 NJK14047 is a selective biphenyl amide p38 MAPK inhibitor which can be used in anti-viral approach targeting hepatitis B virus.
CSN22457 MAPK13-IN-1 229002-10-2 MPAK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC50 of 620 nM.
CSN16041 LY2228820 862507-23-1 LY2228820 is a potent p38MAPK inhibitor with IC50 of 7 nM and 3 nM for p38αMAPK and p38βMAPK.
CSN18346 Losmapimod 585543-15-3 Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively.
CSN22233 ITX5061 1252679-52-9 ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).
CSN22404 FR 167653 158876-66-5 FR-167653 is a selective p38 MAPK inhibitor.
CSN22405 FR 167653 Free Base 158876-65-4 FR-167653 is a selective p38 MAPK inhibitor.
CSN10856 Doramapimod 285983-48-4 Doramapimod is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ.
CSN19850 Deoxynivalenol 51481-10-8 Deoxynivalenol is a tricothecene mycotoxin and potent protein synthesis inhibitor.
CSN19015 Dehydrocorydaline Chloride 10605-03-5 Dehydrocorydaline chloride is an alkaloidal that has anti-inflammatory and anti-cancer activities.
CSN20299 CBS-3595 452056-93-8 CBS-3595 is a dual p38α MAPK/PDE-4 inhibitor with activity against TNFα -related diseases.
CSN18737 BMS-582949 623152-17-0 BMS-582949 is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13 nM,inhibiting both p38 kinase activity and activation of p38.
CSN18566 BMS-582949 HCl 912806-16-7 BMS-582949 hydrochloride is a highly selective p38α MAPK inhibitor, inhibits p38α with IC50 of 13 nM.
CSN22119 AZD7624 1095004-78-6 AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.
CSN22609 AZ304 942507-42-8 AZ304 is an inhibitor of BRAF and can target many kinases. The IC50s for wild type BRAF, V600E mutant BRAF and wild type CRAF are 79 nM, 38 nM and 68 nM, respectively. It can also inhibit p38 (IC50 = 6 nM) and CSF1R (IC50 = 35 nM).
CSN19454 Asiatic Acid 464-92-6 Asiatic acid is a pentacyclic triterpene isolated from a variety of plants, commonly used in wound healing by increasing collagen production.
CSN19014 Acumapimod 836683-15-9 Acumapimod is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α.
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