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ATM/ATR

ATM/ATR

货号 产品名 CAS号 信息
CSN15802 VE-822 1232416-25-9 VE-822 is an ATR inhibitor with IC50 of 19 nM in HT29 cells.
CSN15863 VE-821 1232410-49-9 VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.
CSN17548 Mirin 1198097-97-0 Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity.
CSN15844 KU-60019   925701-46-8 KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM.
CSN17114 KU-55933   587871-26-9 KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 13 and 2.2 nM, respectively and highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
CSN17142 CP-466722 1080622-86-1 CP-466722, a potent and reversible ATM inhibitor, does not affect ATR and inhibits PI3K or PIKK family members in cells.
CSN13686 Chloroquine Diphosphate 50-63-5 Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug.
CSN16057 CGK733 905973-89-9 CGK 733 is an inhibitor of ATM and ATR with IC50 of ~200 nM, also induces cell death in prematurely senescent breast cancer cells.
CSN20269 BAY-1895344 1876467-74-1 BAY-1895344 is a potent and selective ATR inhibitor with IC50 of 7 nM.
CSN17205 AZD6738 1352226-88-0 AZD6738 is a highly selective and potent inhibitor of ATR kinase activity with IC50 value of 1nM in isolated enzyme assay and showed inhibitory effect on ATR kinase-dependent cellular Chk1 phosphorylation with IC50 value of 74nM.
CSN23317 AZD1390 2089288-03-7 AZD1390 is an ATM inhibitor with IC50 of 0.78 nM in cells.
CSN18824 AZD0156   1821428-35-6 AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities.
CSN22539 AZ32 2288709-96-4 AZ32 is an ATM inhibitor with IC50 <6.2 nM in enzyme assays and 310 nM in cellular assays.
CSN15890 AZ 20 1233339-22-4 AZ 20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM exhibiting 8-fold selectivity over mTOR (IC50=38 nM).
CSN22698 AZ 5704 1941214-06-7
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