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Dehydrogenase

Dehydrogenase

货号 产品名 CAS号 信息
CSN18402 Vidofludimus 717824-30-1 Vidofludimus is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH, used as a immunosuppressive drug.
CSN12146 Trilostane 13647-35-3 Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase for Cushing's syndrome.
CSN11548 Teriflunomide(Random Configuration) 108605-62-5 Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines.
CSN13699 Teriflunomide 163451-81-8 Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines.
CSN23145 TC HSD 21 330203-01-5 TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor with an IC50 of 14 nM. TC HSD 21 shows excellent selectivity over 17β-HSD isoenzymes and nuclear receptors[1].
CSN22561 Sodium 2,2-dichloroacetate 2156-56-1 Sodium 2,2-dichloroacetate is a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50s of 183 and 80 μM for PDK2 and PDK4 respectively, with tumor growth inhibition properties.
CSN22557 RRx-001 925206-65-1 RRx-001 is a potent inhibitor of glucose 6-phosphate dehydrogenase (G6PD).
CSN21792 Phenylglyoxal hydrate 1075-06-5 Phenylglyoxal Hydrate is a potent inhibitor of mitochondrial aldehyde dehydrogenase (ALDH), binding the arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties.
CSN23240 Oxalacetic Acid 328-42-7 Oxaloacetic Acid substrate for malate dehydrogenase and oxaloacetate decarboxylase. Oxaloacetic Acid is an inhibitor of SDH.
CSN19396 Mycophenolic Acid 24280-93-1 Mycophenolic Acid is an an immunosuppresant agent with a potent inibition of IMPDH (inosine monophosphate dehydrogenase) and potent anti-proliferative activity, it can be isolated from several Penicillium species.
CSN16132 Mycophenolate Mofetil 128794-94-5 Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively.
CSN19079 ML390 2029049-79-2 ML390 is a human DHODH inhibitor that induces differentiation in acute myeloid leukemia.
CSN16462 Leflunomide 75706-12-6 Leflunomide is a dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 2.5 μM, it is a disease-modifying antirheumatic drug (DMARD) and inhibits de novo pyrimidine synthesis.
CSN22446 LDH-IN-1 1964515-43-2 LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively.
CSN24832 LDH-A Inhibitor III 1269802-68-7 LDH-A Inhibitor III is a potent and reversible LDH-A inhibitor.
CSN11234 Isovaleramide 541-46-8 Isovaleramide, a liver alcohol dehydrogenases inhibitor, is an anticonvulsant molecule isolated from Valeriana pavonii.
CSN19090 GNE-140 Racemate 1802977-61-2 GNE-140 racemate is a LDHA inhibitor.
CSN16160 Glycyrrhizic Acid 1405-86-3 Glycyrrhizic Acid is a naturally occuring non-selective and competitive 11β-hydroxysteroid dehydrogenase inhibitor with protective effect against glucocorticoid-induced osteoporosis. It also inhibited HMGB1.
CSN16654 Gimeracil 103766-25-2 Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine including 5-fluorouracil in the blood and inhibits homologous recombination.
CSN19521 Fomepizole 7554-65-6 Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase which plays a key role in the metabolism of ethylene glycol and methanol.
CSN20383 Crocetin 27876-94-4 Crocetin, a saffron derivative, is an inhibitor of human lactate dehydrogenase 5 in the antiglycolytic approach against cancer.
CSN15809 CPI-613 95809-78-2 CPI-613 is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. CPI-613 has been granted orphan drug status by the US FDA for pancreatic cancer.
CSN20448 Carbenoxolone 5697-56-3 Carbenoxolone is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.
CSN20425 Carbenoxolone Disodium 7421-40-1 Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.
CSN20563 BMS-823778 1140898-87-8 BMS-823778 is an orally available potent and selective inhibitor of 11-β-hydroxysteroid-dehydrogenase 1 (11βHSD-1). BMS-823778 is an antihyperglycaemic that may be a potential candidate for Type 2 diabetes treatment.
CSN20222 BMS-816336 1009583-20-3 BMS-816336, a hydroxyl-substituted adamantyl acetamide, has been identified as a potent inhibitor against human 11β-hydroxysteroid dehydrogenase type 1(11β-HSD1) enzyme (IC50 3.0 nM) with > 10000 fold selectivity over human 11β-hydroxysteroid dehydrogenase type 2(11β-HSD2).
CSN19747 BI-135585 1114561-85-1 BI-135585 is a potent and selective 11β-HSD1 inhibitor for treating Type 2 diabetes.
CSN25625 BAY 2402234 2225819-06-5 BAY 2402234 is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor. It potently inhibited proliferation of AML cell lines in the sub-nanomolar to low-nanomolar range in vitro and exhibited strong in vivo anti-tumor efficacy in monotherapy in several subcutaneous and disseminated AML xenografts as well as AML patient-derived xenograft (PDX) models.
CSN20651 AZD4017 1024033-43-9 AZD4017 is a potent, selective, and orally bioavailable11β-HSD1 inhibitor (11β-hydroxysteroid dehydrogenase type 1 inhibitor). Inhibition of 11β-HSD1 is an attractive mechanism for the treatment of obesity and other elements of the metabolic syndrome.
CSN25633 AZ 33 1370290-34-8 AZ 33 is a Lactate Dehydrogenase A inhibitor with IC50 value of 0.5μM.
CSN22691 ASP 9521 1126084-37-4 ASP 9521 is a potent and selective AKR1C3 inhibitor with IC50 of 11 nM for human AKR1C3.
CSN22599 Ammonium Glycyrrhizinate(x:1) 1407-03-0 Ammonium Glycyrrhizinate inhibits growth and cytopathology of several unrelated DNA and RNA viruses.
CSN23342 3-Methylpyrazole 1453-58-3 3-Methylpyrazole is a nitrification inhibitor of nitrification in soil.
CSN22939 (R)-GNE-140 2003234-63-5 (R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor with IC50s of 3 nM and 5 nM for LDHA and LDHB respectively.
CSN25384 Brequinar 96187-53-0
CSN25383 Brequinar sodium 96201-88-6
CSN25455 Ethyl potassium malonate 6148-64-7
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