|CSN18544||XL228||898280-07-4||XL228 is a protein kinase inhibitor targeting IGF1R, the Aurora kinases, FGFR1-3, ABL and SRC family kinases.|
|CSN13582||PQ401||196868-63-0||PQ401, a selective insulin-like growth factor-1 receptor blocker, is a diarylurea compound that inhibits IGF1R autophosphorylation with IC50 < 1 μM.|
|CSN16148||Picropodophyllin||477-47-4||Picropodophyllotoxin is an orally active insulin-like growth factor-1 receptor (IGF-1R) inhibitor with IC50 of 1 nM, and exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II.|
|CSN18292||NVP-AEW541||475489-16-8||NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM, 27-fold greater selectivity for IGF-1R than InsR.|
|CSN16546||NVP-ADW742||475488-23-4||NVP-ADW742 is an selective IGF-1R inhibitor with IC50 of 0.17 μM, > 16-fold more potent against IGF-1R than InsR and shows little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.|
|CSN15820||NT157||1384426-12-3||NT157 treatment resulted in dose-dependent inhibition of IGF1R activation, suppression of IRS protein expression, inhibition of IGF1-induced AKT activation, but increased ERK activation in NT157-treated cells in vitro.|
|CSN16044||Linsitinib||867160-71-2||Linsitinib is highly potent, orally efficacious and highly selective, dual ATP-competitive inhibitor of IGF-1R (IC50= 35 nM) and insulin receptor (IC50=75 nM).|
|CSN22597||Insulin, Human||11061-68-0||Insulin, Human is a two-chain polypeptide hormone produced by the β-cells of pancreatic islets, it regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.
|CSN23730||Insulin, Bovine||11070-73-8||Insulin, Bovine is a two-chain polypeptide hormone produced by the β-cells of pancreatic islets, it regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.
|CSN17454||GSK1904529A||1089283-49-7||GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, being > 100-fold selective for IGF-1R/InsR than Akt1/2, Aurora A/B,B-Raf, CDK2, EGFR etc.|
|CSN16594||GSK1838705A||1116235-97-2||GSK1838705A is a potent small-molecule IGF-IR, the insulin receptor and anaplastic lymphoma kinase (ALK) inhibitor with IC50 of 2.0, 1.6 and 0.5 nM, respectively.|
|CSN15865||BMS-754807||1001350-96-4||BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM, less potent to Met, Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc.|
|CSN21409||AZ7550 Mesylate||N/A||AZ7550 Mesylate is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.|
|CSN13710||AG1024||65678-07-1||AG1024 inhibits IGF-1R autophosphorylation with IC50 of 7 μM, less potent to IR with IC50 of 57 μM.|