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Sodium Channel

Sodium Channel

货号 产品名 CAS号 信息
CSN25305 Tenapanor 1234423-95-0 Tenapanor is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kidney, with IC50 values of 5 and 10 nM against human and rat NHE3, respectively.
CSN27571 Ropivacaine mesylate 854056-07-8 Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup>. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane.
CSN27570 (S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide 84057-95-4 Ropivacaine is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is a local anesthetic agent widely used for regional anesthesia and neuropathic pain management in vivo.
CSN12787 N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamide dihydrochloride 95635-56-6 Ranolazine 2HCl is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.
CSN26308 Ralfinamide mesylate 202825-45-4 Ralfinamide mesylate is an blocker of Na+ channel with function of suppressing pain.
CSN24710 Ralfinamide 133865-88-0 Ralfinamide (FCE-26742A) is an orally available Na+ blocker derived from α-aminoamide, with function of suppressing pain .
CSN18533 PH-064 892546-37-1 PH-064 is a sodium channel inhibitor. It is also a selective Gαq inhibitor. It traps Gαq in the empty pocket conformation by permitting GDP exit but interdicting GTP entry.
CSN26169 PF-06305591 1449473-97-5 PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with IC50 of 15 nM. It shows excellent preclinical in vitro ADME and safety profile.
CSN26313 PF-01247324 875051-72-2 PF-01247324 is a selective Nav1.8 channel blocker with an IC50 of 196 nM.
CSN26179 N-Me-aminopyrimidinone9 1356834-62-2 N-Me-aminopyrimidinone 9 is an improved Nav1.7 antagonist with minimal off-target hERG liability, and improved rat PK properties.
CSN21733 Nicotinoyl cyclandelate 39537-99-0 Micinicate, a local anesthetic, can reversibly block transient Na+ inward current as well as the steady-state K+ outward current.
CSN27572 Mepivacaine 96-88-8 Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization.
CSN13632 Lidocaine 137-58-6 Lidocaine HCl is antiarrhythmic agent and used as a local anesthetic.
CSN11299 Lidocaine HCl 73-78-9 Lidocaine HCl is antiarrhythmic agent and used as a local anesthetic.
CSN25458 10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide 29331-92-8 Licarbazepine, also known as BIA-2-005; GP-47779; LIC-477; LIC-477D; TRI-477, is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine. It is an active metabolite of oxcarbazepine. In addition, an isomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate. Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.
CSN12632 (3S,6S,6aR,7S,7aS,8S,9R,10S,11aS,12S,12aR,14S)-1-ethyl-7a,11a-dihydroxy-6,8,10-trimethoxytetradecahydro-1H-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocin-3-yl 2-acetamidobenzoate 32854-75-4 Lappaconitine is a selective blocker of the TTX-sensitive Na+ channels without influence on the activation threshold of Na+ channels. It is an analgesic alkaloid isolated from Aconitum sinomontanum Nakai..
CSN12998 Lamotrigine 84057-84-1 Lamotrigine is a member of the sodium channel blocking class of antiepileptic drugs which can block L-, N-, and P-type calcium channels and has weak 5-HT3 receptor inhibition.
CSN21637 Sodium ionophore III 81686-22-8 ETH2120 is a Na+ ionophore suitable for the assay of sodium activity in blood.
CSN25462 EIPA 1154-25-2 EIPA (L593754) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
CSN25620 DSP-2230 1233231-30-5 DSP-2230 is a selective Nav1.7/Nav1.8 blocker.
CSN51363 AZ194 2241651-99-8 CRMP2-Ubc9-NaV1.7 inhibitor 194 is a CRMP2-Ubc9-NaV1.7 inhibitor.
CSN32431 Evenamide 1092977-61-1
CSN32430 Piromelatine 946846-83-9
CSN40141 Veratridine 71-62-5
CSN41903 Benzamil 2898-76-2
CSN38648 GNE-0439 1241902-40-8
CSN38350 Nav1.1 activator 1 2332897-85-3
CSN33959 Lu AE98134 849000-18-6
CSN35591 AM-2099 1443373-17-8
CSN35584 PF-04856264 1235397-05-3
CSN42120 Cyano(4-fluoro-3-phenoxyphenyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate 68359-37-5
CSN43403 Nav1.7-IN-3 1788872-06-9
CSN43405 GNE-616 2349371-81-7
CSN43828 PF-05198007 1235406-19-5
CSN43402 PF-05241328 1387633-03-5
CSN51358 GX-674 1432913-36-4
CSN63043 PF-05186462 1235406-03-7
CSN63066 TC-N 1752 1211866-85-1
CSN63345 Flecainide-d4 acetate 1276197-21-7
CSN63457 (R)-Funapide 1259933-15-7
CSN64881 S3969 1027997-01-8
CSN67373 GX-201 1788071-27-1
CSN67713 Idrevloride 1416973-63-1
CSN67909 GDC-0310 1788063-52-4
CSN75789 NAV 26 1198160-14-3
CSN76031 Nav1.8-IN-1 1026822-49-0
CSN78051 ABBV-318 1802848-94-7
CSN79818 Nav1.8-IN-2 2756250-30-1
CSN104104 Nav1.1-IN-B 924862-21-5
CSN51561 AA43279 354812-16-1
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