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Sodium Channel

Sodium Channel

货号 产品名 CAS号 信息
CSN17315 XEN907 912656-34-9 XEN907 is a spirooxindole NaV1.7 blocker, inhibits hNaV1.7 with IC50 of 3 nM.
CSN12135 Triamterene 396-01-0 Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.
CSN12109 Tolperisone HCl 3644-61-9 Tolperisone hydrochloride is a muscle relaxant and an ion channel blocker with antispastic function.
CSN16312 Sodium Channel Inhibitor 1 1198117-23-5 Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a selective voltage-gated sodium channel for pain treatment.
CSN11872 Rufinamide 106308-44-5 Rufinamide, an antiepileptic agent, is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS).
CSN12526 Ropivacaine HCl H2O 132112-35-7 Ropivacaine hydrochloride, a local anaesthetic, can reversibly inhibit sodium ion influx and block impulse propagation along nerve fibres.
CSN24189 Rimeporide 187870-78-6 Rimeporide is a potent and selective NHE1 inhibitor.
CSN12584 Riluzole 1744-22-5 Riluzole is an antagonist of glutamate that used as an anticonvulsant. It can prolong the survival of patients with amyotrophic lateral sclerosis.
CSN11788 Propoxycaine HCl 550-83-4 Propoxycaine hydrochloride is the hydrochloride salt form of propoxycaine, a para-aminobenzoic acid ester with local anesthetic activity.
CSN11785 Propafenone HCl 34183-22-7 Propafenone hydrochloride, a class I antiarrhythmic drug, is an inhibitor of voltage-dependent sodium channels and treats illnesses associated with rapid heart beats.
CSN11774 Procaine 59-46-1 Procaine, a benzoic acid derivative, is an anesthetic drug through targeting multiple proteins.
CSN13879 Procainamide HCl 614-39-1 Procainamide hydrochloride is a blocker of sodium channel and an inhibitor of DNA methyltransferase. It is an anti-arrhythmic agent.
CSN16780 Prilocaine 721-50-6 Prilocaine is a local anesthetic of the amino amide type.
CSN11719 Pilsicainide 88069-67-4 Pilsicainide is a sodium channel blocker and an antiarrhythmic agent and a drug to treat cardiac arrhythmias in Japan.
CSN16772 Phenytoin Sodium 630-93-3 Phenytoin sodium is a stabilizer of inactive voltage-gated sodium channel.
CSN12795 Phenytoin 57-41-0 Phenytoin is an inactive voltage-gated sodium channel stabilizer.
CSN13891 PF-05089771   1235403-62-9 PF-05089771 is a Nav1.7 channel blocker with an IC50 of 8.6 nM.
CSN10399 Oxybuprocaine HCl 5987-82-6 Oxybuprocaine hydrochloride can bind to sodium channel, reversibly stabilize the neuronal membrane and decrease permeability of sodium ions. It is a local anesthetic used in ophthalmology and otolaryngology.
CSN16737 Oxcarbazepine 28721-07-5 Oxcarbazepine is a voltage-gated sodium channel blocker with IC50 of 160 μM and it is used for the treatment of partial seizure.
CSN17076 Nicainoprol 76252-06-7 Nicainoprol is a sodium channels blocker which is used as an antiarrhythmic agent.
CSN11533 Nefopam HCl 23327-57-3 Nefopam, a non-opioid analgesic drug, is blocker of voltage-gated sodium channel and inhibitor of serotonin, dopamine and noradrenaline reuptake. It is used to relieve pain.
CSN17697 Nav1.7-IN-2 1332295-35-8 Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50 of 80 nM.
CSN16914 Nav1.7 Inhibitor 1355631-24-1 Nav1.7 inhibitor is a sulfonamide derivative with potent Nav1.7 inhibition activity.
CSN10544 Moricizine 31883-05-3 Moricizine is an antiarrhythmia agent used primarily for ventricular rhythm disturbances.
CSN10095 Mexiletine HCl 5370-01-4 Mexiletine hydrochloride is a non-selective blocker of voltage-gated sodium channel. It blongs to the anti-arrhythmic compounds of class IB .
CSN16180 Mepivacaine HCl 1722-62-9 Mepivacaine, a tertiary amine, is used as a local anesthetic.
CSN11300 Lidocaine HCl H2O 6108-05-0 Lidocaine hydrochloride is antiarrhythmic agent and used as a local anesthetic.
CSN16268 Levobupivacaine HCl 27262-48-2 Levobupivacaine hydrochloride is a local anaesthetic compound belonging to the amino amide group and a long-acting local anesthetic.
CSN12998 Lamotrigine 84057-84-1 Lamotrigine is a member of the sodium channel blocking class of antiepileptic drugs which can block L-, N-, and P-type calcium channels and has weak 5-HT3 receptor inhibition.
CSN18204 ICA-121431 313254-51-2 ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, but no inhibition on human, monkey and dog Nav1.7.
CSN16320 GS-967 1262618-39-2 GS-967 is a selective inhibitor of cardiac late sodium current (late INa ). The IC50 values in ventricular myocytes and isolated hearts are 0.13 μM and 0.21 μM.
CSN11017 Flecainide 54143-55-4 Flecainide acetate, a class Ic antiarrhythmic agent, can block the Nav1.5 sodium channel and inhibit ryanodine receptor 2 (RyR2). It is used to prevent and treat tachyarrhythmias.
CSN11018 Flecainide Acetate 54143-56-5 Flecainide Acetate is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia and works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
CSN10881 Dyclonine HCl 536-43-6 Dyclonine hydrochloride is the hydrochloride form of dyclonine which can reversibly bind to activated sodium channels on the neuronal membrane. It is an anaesthetic found in sucrets.
CSN13878 CNV1014802 934240-30-9 CNV1014802 is a blocker of Nav1.7 sodium channel.
CSN15719 CNV1014802 HCl 934240-31-0 CNV1014802 hydrochloride is a blocker of Nav1.7 sodium channel with analgesic effects.
CSN16283 Carbamazepine 298-46-4 Carbamazepine is a blocker of sodium channel with IC50 of 131 μM in rat brain synaptosomes. It is an anticonvulsant drug.
CSN11492 Camostat Mesilate 59721-29-8 Camostat mesylate is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trypsin, prostasin and matriptase.
CSN16147 Bupivacaine 38396-39-3 Bupivacaine, an amide local anesthetic, reversibly binds to specific sodium ion channels that decreases the stabilization of membrane .
CSN10506 Bulleyaconitine A 107668-79-1 Bulleyaconitine A is an alkaloid with analgesic and anti-inflammatory activities. It is found in Aconitum bulleyanum and used for the treatment of chronic pain and rheumatoid arthritis.
CSN16674 Benzocaine 94-09-7 Benzocaine, the ethyl ester of p-aminobenzoic acid (PABA), inhibits voltage-dependent sodium channels (VDSCs) on the neuron membrane and used as a local anesthetic.
CSN10281 Amiloride HCl 2H2O 17440-83-4 Amiloride hydrochloride blocks epithelial sodium channel (ENaC) and is used to treat hypertension and congestive heart failure.
CSN11757 Ambroxol HCl 23828-92-4 Ambroxol hydrochloride is an inhibitor of neuronal Na+ channels. It inhibits TTX-resistant and sensitive Na+ currents with IC50 of 35.2 μM (tonic)/22.5 μM (phasic block) and 100 μM, respectively.
CSN16066 A 803467 944261-79-4 A 803467 selectively block Nav1.8 sodium channel with IC50 of 8 nM.
CSN12884 (-)-Sparteine Sulfate Pentahydrate 6160-12-9 (-)-Sparteine sulfate is a class 1a antiarrhythmic agent and a sodium channel blocker.
CSN16841 (-)-Sparteine 90-39-1 (-)-Sparteine is a class 1a antiarrhythmic agent and a sodium channel blocker.
CSN12547 Bupivacaine hydrochloride 18010-40-7
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