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FLT3

FLT3

货号 产品名 CAS号 信息
CSN15695 UNC2025 1429881-91-3 UNC2025 is an inhibitor of Mer and Flt3 with IC50 of 0.8 nM and 0.74 nM, respectively.
CSN19156 UNC2025 HCl 2070015-17-5 UNC2025 HCl is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.
CSN13941 TCS 359 301305-73-7 TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM.
CSN12033 Tandutinib 387867-13-2 Tandutinib is an antagonist of FLT3 with IC50 of 0.22 μM and can also inhibit PDGFR and c-Kit thereby inhibiting cellular proliferation and inducing apoptosis.
CSN20533 SU-5614 1055412-47-9 SU-5614 is an inhibitor of FLT3. In Ba/F3 and AML cell lines expressing a constitutively activated FLT3, SU-5614 exhibits significant cell growth inhibition and cell cycle arrest.
CSN13100 Quizartinib 950769-58-1 Quizartinib is a second-generation FLT3 inhibitor for Flt3 (ITD/WT) with IC50 of 1.1 nM/4.2 nM, being 10-fold selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R.
CSN17304 KW-2449 1000669-72-6 KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC50 of 6.6 nM, modestly potent to FGFR1, Bcr-Abl and Aurora A, and showing little effect on PDGFRβ, IGF-1R, EGFR.
CSN13926 Gilteritinib 1254053-43-4 Gilteritinib is a potent FLT3/AXL inhibitor with IC50 of 0.29 nM/< 1 nM respectively and shows potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations.
CSN13783 G-749 1457983-28-6 G-749 is a FLT3 inhibitor that showed potent and sustained inhibition of the FLT3 wild type and mutants with IC50s of 0.4/0.6/3.5/7.5 nM for Wt Flt3/D835Y/MV4-11/Molm-14 respectively.
CSN16867 FLT3-IN-2 923562-23-6 FLT3-IN-2 is a FLT3 inhibitor with IC50 of < 1 μM.
CSN21240 FLT3-IN-1 Succinate 1702864-11-6 FLT3-IN-1 Succinate is a potent FLT3 inhibitor extracted from patent WO2015056683A1, compound example A.
CSN21235 FLT3-IN-1 1472797-69-5 FLT3-IN-1 is a potent FLT3 inhibitor extracted from patent WO2015056683A1, compound example A
CSN16265 SKLB4771 1370256-78-2 FLT3-IN-1 is a potent and selective Flt3 inhibitor with IC50 of 10 nM and against FLT3-ITD-expressing MV4-11 cells with IC50 of 6 nM.
CSN20591 Famitinib 1044040-56-3 Famitinib, a structural analogue of sunitinib, is a multi-targeted receptor tyrosine kinase inhibitor which is potential for treatment of renal cell carcinoma, gastrointestinal stromal tumours, pancreatic cancer, and nasopharyngeal carcinoma.
CSN16610 ENMD-2076 Tartrate 1453868-32-0 ENMD-2076 tartrate has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα.
CSN18598 ENMD-2076 934353-76-1 ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα.
CSN16257 BPR1J-097 1327167-19-0 BPR1J-097 is a small molecule FLT-3 inhibitor (IC50=11±7 nM) with promising in vivo anti-tumour activities, inhibiting FLT-3 D835Y with an IC50 of 3 nM.
CSN21227 Gilteritinib Hemifumarate 1254053-84-3
CSN22654 5'-Fluoroindirubinoxime 861214-33-7
CSN22754 CHMFL-FLT3-122 1839150-56-9
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