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CDK

CDK

货号 产品名 CAS号 信息
CSN17512 XL413 1169558-38-6 XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, > 60-fold selectivity against CK2, > 10-fold selectivity against PIM, and > 300-fold selectivity against a panel of over 100 protein kinases.
CSN16984 WHI-P180 211555-08-7 WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 μM, respectively.
CSN25265 Trilaciclib 1374743-00-6 Trilaciclib is an inhibitor of CDK4 and CDK6 with IC50s of 1 nM and 4 nM, respectively.
CSN24801 TP353   1253799-29-9 TP353 is a CDK7 inhibitor.
CSN16121 TG-003 719277-26-6 TG003 is a potent inhibitor of Clk1/Sty and Clk4 with IC50 of 15-20 nM, less potency on Clk2 (IC50= 200 nM).
CSN16666 SU9516 377090-84-1 SU9516 is a selective and potent CDK2 inhibtor with IC50 of 22 nM, less potent for CDK1/CDK4 (IC50=40/200 nM), and with no inhibition on PKC, EGFR, p38MAPK, etc.
CSN25349 SR-4853 2387704-62-1 SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 with IC50 of 99 nM, Kd of 98 nM for CDK12 and Kd of 4.9 nM for CDK13. It acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death.
CSN23674 SEL120-34A HCl 1609452-30-3 SEL120-34A HCl is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity.
CSN16049 SCH-900776 891494-63-6 SCH 900776 (MK-8776) is a selective and highly potent CHK1 inhibitor with IC50 value of 3nM, modest to CDK2 and Chk2 with much higher IC50 values of 160nM and 1.5uM, respectively.
CSN19761 Roniciclib 1223498-69-8 Roniciclib is an orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity, selectively binds to and inhibits the activity of CDK1/Cyclin B, CDK2/Cyclin E, CDK4/Cyclin D1, and CDK9/Cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle progression and cellular proliferation.
CSN16564 Ro 3306 872573-93-8 Ro 3306 is a potent and selective inhibitor of CDK1 with Ki value of 35 nM for CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and > 50-fold relative to CDK4/cyclin D.
CSN16126 R547 741713-40-6 R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.
CSN16119 Purvalanol B 212844-54-7 Purvalanol B is a selective cyclin-dependent kinases (CDKs) inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.
CSN11800 Purvalanol A 212844-53-6 Purvalanol A is a selective inhibitor of cyclin-dependent kinases (CDKs), it potently inhibits cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35 with IC50 values of 4, 70, 35, 850, and 75 nM respectively.
CSN25543 PNU 112455A 21886-12-4 PNU112455A HCl is an ATP site competetive inhibitor of CDK2 and CDK5. The Km for binding to the ATP site of CDK2 and CDK5 is 3.6 and 3.3 mM, respectively.
CSN12713 PHA-848125 802539-81-7 PHA-848125 is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM, being > 3-fold selective for CDK2 than CDK1, 2, 4, 5, and 7.
CSN17186 PHA-793887 718630-59-2 PHA-793887 is a pan-cdk inhibitor, inhibits cdk1/2/4/5/7/9 with IC50s of 5 - 140 nM.
CSN15827 Palbociclib Isethionate 827022-33-3 Palbociclib isethionate is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases.
CSN15851 Palbociclib HCl 827022-32-2 Palbociclib HCl is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases.
CSN16662 P276-00 920113-03-7 P276-00 is a CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively.
CSN11589 NU2058 161058-83-9 NU2058 is a CDK inhibitor with IC50 of 17 μM and 26 μM for CDK2 and CDK1.
CSN25261 NSC-95397 93718-83-3 NSC 95397 is irreversible Cdc25 dual specificity phosphatase inhibitor with Ki values of 32, 96, and 40 nM for Cdc25A, Cdc25B, and Cdc25C, respectively.
CSN17570 LEE011 HCl 1211443-80-9 LEE011 HCl is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
CSN16940 LDC000067 1073485-20-7 LDC000067 is a highly specific CDK9 inhibitor with IC50 of 32.7 nM for CDK9/cyclin T1.
CSN17741 KH-CB19 1354037-26-5 KH-CB19 is a potent and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).
CSN12858 JNJ-7706621 443797-96-4 JNJ-7706621 is a pan-CDK inhibitor that inhibits CDK1/2 with IC50 of 9/4 nM, also potently inhibits Aurora A/B.
CSN11014 Flavopiridol 146426-40-6 Flavopiridol is a pan CDK inhibitor with IC50 values of 30nM, 40nM, 20-40nM, 60nM, 875nM and 20nM for CDK1, 2, 4, 6, 7, 9, respectively
CSN11015 Flavopiridol HCl 131740-09-5 Flavopiridol HCl competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM.
CSN24779 EHT 5372 1425945-60-3 EHT 5372 is a strong inhibitor of DYRK’s family kinases, with IC50s of 0.22, 0.28 nM for DYRK1A and DYRK1B, respectively.
CSN17780 CDK9-IN-6 1391855-95-0 CDK9-IN-6 is a CDK9 inhibito.
CSN17642 CDK9-IN-2 1263369-28-3 CDK9-IN-2 is a special cyclin-dependent kinase 9 (CDK9) inhibitor with an IC50 of 5 nM and 7 nM in H929 multiple myeloma(MM) cell line (72 hours) and A2058 skin cell line (72 hours), respectively.
CSN17649 CDK-IN-2 1269815-17-9 CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of < 8 nM.
CSN23778 cc671 1618658-88-0 CC-671 is a selective inhibitor of TTK (Mps1) and CLK2 with IC50s of 5 nM and 3 nM, respectively.
CSN23969 BSJ-03-123 2361493-16-3 BSJ-03-123 is a PROTAC selectively targeting on CDK6, consist of a warhead palbociclib (a CDK inhibitor) linked to a CRBN ligand pomalidomide.
CSN25245 BS-194 1092443-55-4 BS-194 is a selective and potent CDK inhibitor with IC50 values of 3, 30, 30, 250, and 90nM for CDK2, CDK1, CDK5, CDK7, and CDK9, respectively.
CSN17151 BS-181 HCl 1397219-81-6 BS-181 is a selective CDK7 inhibitor with IC50 of 21 nM.
CSN16513 BS-181 1092443-52-1 BS-181 is a highly selective CDK7 inhibitor with IC50 of 21 nM.
CSN17259 Briciclib 865783-99-9 Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells.
CSN24819 Bohemine 189232-42-6 Bohemine is a potent and selective, cell-permeable, cyclin-dependent kinase (CDK) inhibitor with IC50 = 1 µM. Bohemine is structurally similar to Olomoucine and Roscovitine.
CSN16547 BMS-265246 582315-72-8 BMS-265246 is a potent and selective CDK1/2 inhibitor for CDK1/cyclin B and CDK2/cyclin E with IC50 of 6 and 9 nM respectively.
CSN25300 BI-1347 2163056-91-3 BI-1347 is a potent CDK8 inhibitor with an IC50 of 1.1 nM.
CSN21503 AZD5438 602306-29-6 AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM.
CSN24735 AZD4573 2057509-72-3 AZD4573 is a potent and selective CDK9 inhibitor with with nanomolar.
CSN21194 Atuveciclib Racemate 1414943-88-6 Atuveciclib Racemate is the racemate form of Atuveciclib.
CSN25869 Atuveciclib 1414943-94-4 Atuveciclib is an orally available and selective PTEFb/CDK9 inhibitor for the treatment of cancer.
CSN15832 AMG-925 1401033-86-0 AMG-925 is a potent and selective dual inhibtor of CDK4/FLT3 with IC50s of 1.5 nM and 2.4 nM for CDK4 and FLT3, respectively, and with IC50 of 19 nM in MOLM-13 cell.
CSN13886 LY2835219 1231930-82-7 Abemaciclib Methanesulfonate is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM respectively, used for the treatment of advanced or metastatic breast cancers.
CSN15805 Abemaciclib 1231929-97-7 Abemaciclib is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM respectively, used for the treatment of advanced or metastatic breast cancers.
CSN15942 1NM-PP1(PP1 Analog II) 221244-14-0 1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors with IC50 of 28 μM for vSrc and 4.2 nM for v-Src-as1 I338G.
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