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CAS No.: 2079895-42-2

CDK2-IN-4 Catalog No. CSN26129

Synonyms: CDK2-IN-73;CDK2 inhibitor-73

CDK2 inhibitor 73 is a selective CDK2 inhibitor with IC50 value of 44nM.

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400-920-2911

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技术信息

生物活性

描述The cyclin-dependent kinase (CDK) family of serine/threonine kinases plays an integral role in the regulation of the eukaryotic cell cycle as well as having key functions in apoptosis, transcription, differentiation, and neuronal function. CDK2 inhibitor 73 is a potent and selective CDK2 inhibitor (IC₅₀ = 44 nM), exhibiting some 2000-fold-selectivity over CDK1 (IC₅₀ = 86 μM)^[1].
作用机制The purine ring of CDK2 inhibitor 73 occupys the CDK2 ATP binding site, and makes a triplet of hydrogen bonds with the backbone carbonyl of Glu81 and the amide NH and carbonyl moieties of Leu83 within the hinge sequence^[1].
参考文献

[1] Coxon CR, et al. Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem. 2017 Mar 9;60(5):1746-1767

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2599 mL
- 11.2996 mL
- 22.5992 mL
- 5 mM
- 0.4520 mL
- 2.2599 mL
- 4.5198 mL
- 10 mM
- 0.2260 mL
- 1.1300 mL
- 2.2599 mL

技术信息

CAS号

2079895-42-2

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H18N6O2S

运输

蓝冰

分子量

442.49

别名

CDK2-IN-73;CDK2 inhibitor-73

溶解度

DMSO	88.0 mg/mL (198.9 mM)
Water	Insoluble
Ethanol	Insoluble

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