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Coumarins

Coumarins

货号 产品名 CAS号 信息
CSN12220 Xanthotoxol 2009-24-7 Xanthotoxol, a natural product isolated and purified from the fruits of Cnidium monnieri, has neuroprotection, due to the ability of xanthotoxol to attenuate the expression of pro-inflammatory mediators and thereby inhibit the inflammatory response after cerebral ischemia.
CSN14013 Wedelolactone 524-12-9 Wedelolactone, a natural compound derived from Chinese herbal medicine Eclipta prostrate L, is an anti-cancer agent for breast and prostate carcinomas in vitro and in vivo targeting multiple cellular proteins including androgen receptors, 5-lipoxygenase and topoisomerase IIα.
CSN13084 Umbelliferone 93-35-6 Umbelliferone, a natural product isolated and purified from the herbs of Ruta graveolens L., exhibits significant anticancer effects via the induction of apoptosis, cell cycle arrest and DNA fragmentation in HepG2 cancer cells.
CSN13943 Suberosin 581-31-7 Suberosin, a natural product isolated and purified from the roots of Angelica pubescens, inhibits PHA-induced PBMC proliferation, at least in part, through reduction of [Ca2+]i, ERK, NF-AT, and NF-kappaB activation, and early gene expression in PBMC including cyclins and cytokines, and arrest of cell cycle progression in the cells.
CSN13982 Sphondin 483-66-9 Sphondin, a natural product isolated and purified from the fruits of Heracleum sibiricum L., possesses an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.
CSN13328 Scopoletin Acetate 56795-51-8 Scopoletin acetate is a natural product isolated and purified from the herbs of Atropa belladonna L..
CSN14016 Samidin 477-33-8 Samidin, a natural product isolated and purified from the fruits of Ammi visnaga., has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
CSN14011 Phebalosin 6545-99-9 Phebalosin, a natural product isolated and purified from the herbs of Murraya exotica L., displays EC(50) of 14.1 mg/mL against axenic amastigote forms of Leishmania panamensis. and cytotoxicity (IC(50)) at concentrations of 20.7 mg/mL on human promonocytic U-937 cells.
CSN14017 Oxypeucedanin Hydrate 133164-11-1 Oxypeucedanin is a chemical constituent from polarity part in roots of Angelica dahurica var. formosana cv. Chuanbaizhi.
CSN13525 Notopterol   88206-46-6 Notopterol induces apoptosis and inhibits cell cycle-specific, it's a natural product isolated and purified from the roots of Notopterygium incisum.
CSN12625 Methoxsalen 298-81-7 Methoxsalen is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juice/fruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. It is a potent suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight.
CSN14004 Meranzin Hydrate   5875-49-0 Meranzin, a natural product isolated and purified from the roots of Angelica biserrata, produces a rapid effect mediated by AMPA receptors and involving BDNF modulation through the ERK1/2 pathway. Meranzin can also induce similar effect to Fructus Aurantii on intestinal motility and it was, at least in part, mediated by stimulation of H1 histamine receptors, and exhibits antidepressive and prokinetic-like effects through the regulation of the common mediator, the alpha 2-adrenoceptor , and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.
CSN14012 Meranzin 23971-42-8 Meranzin, a natural product isolated and purified from the peel of Citrus maxima, can induce similar effect to Fructus Aurantii on intestinal motility and it was, at least in part, mediated by stimulation of H1 histamine receptors.
CSN13967 Mellein 480-33-1 Mellein is a natural product isolated and purified from the herbs of Goniothalamus griffithii.
CSN10961 Isofraxidin 486-21-5 Isofraxidin, a natural product isolated and purified from the herbs of Sarcandra glabra (Thunb.) Nakai, possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2.
CSN13966 Heraclenol 31575-93-6 Heraclenol, a natural product isolated and purified from the herbs of Heracleum repula Franch, can inhibit the proliferation of melanoma cells and cell cycle.
CSN13981 Heraclenin 2880-49-1 Heraclenin, a natural product isolated and purified from the fruits of Citrus aurantium L., induces apoptosis in Jurkat leukemia cells in mechanistically different ways.
CSN11055 Fraxin   524-30-1 Fraxin protects HUVECs from oxidative stress, enhances urate excretion partly by inhibiting mURAT1 or mGLUT9 in kidney of hyperuricemic mice. It is a natural product isolated and purified from the bark of Fraxinus brngeana DC..
CSN11054 Fraxidin 525-21-3 Fraxidin is a natural product isolated and purified from the herbs of Sarcandra glabra.
CSN10170 Fraxetin 574-84-5 Fraxetin, a natural product isolated and purified from the bark of Fraxinus brngeana DC., has protective against rotenone-induced cytotoxicity, apoptotic death and antioxidant activities.
CSN12630 Esculetin 305-01-1 Esculetin is a naturally occuring 5-lipoxygenase and 12-Lipoxygenase inhibitor with IC50 values of ID50 values of 4 and 2.5 µM, respectively.
CSN10134 Dimethylfraxetin 6035-49-0 Dimethylfraxetin is a natural product isolated and purified from the herbs of Viola yedonensis Makino with anti-HRV-2 activity.
CSN10815 Dihydrocoumarin 119-84-6 Dihydrocoumarin, a natural product isolated and purified from the leaves of Southern sweet-grass., is widespread used as a flavoring agent in beverages, gelatins, puddings, candy, and other food items. It is also as a fragrance in perfumes, creams, and cosmetics.
CSN13551 Demethylwedelolactone 6468-55-9 Demethylwedelolactone, a natural product isolated and purified from the herbs of Eclipta prostrata, has trypsin inhibitory effect. Demethylwedelolactone exerts anti-invasive growth effect on breast cancer cells.
CSN10746 Daphnoretin 2034-69-7 Daphnoretin, a natural product isolated and purified from the roots of Wikstroemia indica (Linn.) C. A. Mey., has strong antiviral activity, mainly on the later phase of the replication cycle. Daphnoretin also has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells, might through promoting apoptosis in a mitochondria-mediated way.
CSN12343 Coumestrol 479-13-0 Coumestrol, a natural product isolated and purified from the herbs of Erythrina arborescens, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM.
CSN10701 Coumarin 91-64-5 Coumarin is a secondary phytochemical isolated and purified from the herbs of Melilotus officinalis with hepatotoxic and carcinogenic properties.
CSN13447 Chloculol 131652-35-2 Chloculol is a natural product.
CSN10419 Bergaptol 486-60-2 Bergaptol is a hydroxylated psoralen isolated and purified from the root of Notopterygium incisum that acts as a potent inhibitor of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 μM.
CSN10356 Auraptene   495-02-3 Auraptene is a natural product isolated and purified from the peel of Poncirus trifoliata with anti-tumor and anti-oxidant activity. Auraptene-mediated activation of JNK may contribute to the production of Aβ by promoting γ-secretase activity.
CSN12221 8-Geranyloxypsoralen 7437-55-0 8-Geranyloxypsoralen, a natural product isolated and purified from the herbs of Seseli mairei Wolff., inhibits β-secretase (BACE1) activity in non-competitive manner, with the IC(50) values < 25.0 uM. 8-Geranyloxypsoralen possesses nematicidal activities, the median lethal concentrations (LC(50)) is 188.3 mg/ L against B. xylophilus and is 117.5 mg/L against P. redivivus.
CSN13219 8-Geranyloxy-5,7-Dimethoxycoumarin 1228175-65-2 8-Geranyloxy-5,7-dimethoxycoumarin is a natural product isolated and purified from the herbs of Toddalia asiatica with antidiabetic and antioxidant effect.
CSN13223 (S)-Yuehgesin C 125072-68-6 8-(3-Ethoxy-2-hydroxy-3-methylbutyl)-7-methoxycoumarin is a natural product isolated and purified from the herbs of Murraya paniculata.
CSN10943 7-Methoxycoumarin 531-59-9 7-Methoxycoumarin, a natural product isolated and purified from the herbs of Citrus reticulata cv. Chachiensis, has potent antioxidant effect, strong hepatoprotective activity, and weak estrogenic activity.
CSN13043 7-Hydroxy-6-Methoxy-3-Prenylcoumarin 299159-90-3 7-Hydroxy-6-methoxy-3-prenylcoumarin is a natural product isolated and purified from the herbs of Coriaria nepalensis.
CSN13397 7-Hydroxy-3-Prenylcoumarin 86654-26-4 7-Hydroxy-3-prenylcoumarin is a natural product isolated and purified from the herbs of Coriaria nepalensis.
CSN13282 7-Geranyloxy-6-Methoxycoumarin 28587-43-1 7-Geranyloxy-6-methoxycoumarin is a natural product isolated and purified from the herbs of Murraya tetramera Huang, showing significant cytotoxicity against three cell lines (A549, SMMC-7721 and BALL-1).
CSN10955 7-Amino-4-Methylcoumarin   26093-31-2 7-Amino-4-methylcoumarin is a natural product isolated and purified from an endophytic Xylaria fungal species and exhibited strong antibacterial and antifungal activities in vitro against Aspergillus, Candida, Escherichia, Staphylococcus, Salmonella and Vibrio species, among others. It is also a reagent employed in the preparation of fluorogenic AMC-based substrates for the detection of proteolytic enzyme activity. AMC has been utilized as a fluorescent probe to analyze glycoproteins' monosaccharides and N-linked oligosaccharides via chromatography and has been used as a laser dye.
CSN11536 5-Methoxypsoralen 484-20-8 5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation [psoralen plus UV (PUVA)] to manage psoriasis and vitiligo and inhibits proliferation in the human hepatocellular carcinoma cell line.
CSN13341 5,7,8-Trimethoxycoumarin 60796-65-8 5,7,8-Trimethoxycoumarin is a natural product isolated and purified from the herbs of Viola yedonensis Makino.
CSN13327 5,6,7,8-Tetramethoxycoumarin 56317-15-8 5,6,7,8-Tetramethoxycoumarin is a natural product isolated and purified from the herbs of Croton laevigatus.
CSN13076 4-Methylumbelliferone 90-33-5 4-Methylumbelliferone, a natural product isolated and purified from the herbs of Ruta graveolens L., is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.
CSN13450 2-(1-Hydroxy-1-Methylethyl)-4-Methoxy-7H-Furo[3,2-G][1]benzopyran-7-One 54087-32-0 2-(1-Hydroxy-1-methylethyl)-4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one is a natural product isolated and purified from the fruits of Evodia lepta.
CSN14015 (-)-Praeruptorin A 14017-71-1 (-)-Praeruptorin A, a natural product isolated and purified from the herbal medicine Peucedanum praeruptorum, inhibits in vitro migration of preosteoclasts and in vivo bone erosion, possibly due to its potential to target calmodulin.
CSN14018 (-)-Heraclenol 139079-42-8 (-)-Heraclenol is a natural product isolated and purified from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi.
CSN13520 (+)-Praeruptorin A 73069-27-9 (+)-Praeruptorin A is a natural product isolated and purified from the roots of Peucedanum praeruptorum Dunn., which exerted distinct relaxant effects on isolated rat aorta rings, which might be mainly attributed to nitric oxide synthesis catalyzed by endothelial nitric oxide synthase.
CSN13983 (+)-Mellein 62623-84-1 (+)-Mellein is a natural product isolated and purified from the herbs of Goniothalamus griffithii.
CSN13863 Phellopterin 2543-94-4
CSN10152 Isoscopoletin 776-86-3
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