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Coumarins

Coumarins

货号 产品名 CAS号 信息
CSN14098 Xanthoxyletin 84-99-1 Xanthoxyletin, a natural product isolated and purified from the bark of Zanthoxylum elephantiasis.
CSN12220 Xanthotoxol 2009-24-7 Xanthotoxol, a natural product isolated and purified from the fruits of Cnidium monnieri, has neuroprotection, due to the ability of xanthotoxol to attenuate the expression of pro-inflammatory mediators and thereby inhibit the inflammatory response after cerebral ischemia.
CSN14013 Wedelolactone 524-12-9 Wedelolactone, a natural compound derived from Chinese herbal medicine Eclipta prostrate L, is an anti-cancer agent for breast and prostate carcinomas in vitro and in vivo targeting multiple cellular proteins including androgen receptors, 5-lipoxygenase and topoisomerase IIα.
CSN13084 Umbelliferone 93-35-6 Umbelliferone, a natural product isolated and purified from the herbs of Ruta graveolens L., exhibits significant anticancer effects via the induction of apoptosis, cell cycle arrest and DNA fragmentation in HepG2 cancer cells.
CSN13982 Sphondin 483-66-9 Sphondin, a natural product isolated and purified from the fruits of Heracleum sibiricum L., possesses an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.
CSN16505 Skimmin 93-39-0 Skimmin, a natural product isolated and purified from the herbs of Hydrangea paniculata with anti-inflammatory activity, can significantly improve renal function and suppress the IgG deposition as well as the development of glomerular lesions in a rat model of membranous glomerulonephritis, suppress diabetic nephropathy in rats effectively, and may slow down the renal fibrosis by regulating TGF-β1 signal pathway, and show cytotoxic effect on CAOV-4 cell line, with an IC50 of 70.03 ug/mL.
CSN13328 Scopoletin Acetate 56795-51-8 Scopoletin acetate is a natural product isolated and purified from the herbs of Atropa belladonna L..
CSN14016 Samidin 477-33-8 Samidin, a natural product isolated and purified from the fruits of Ammi visnaga., has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
CSN16616 Praeruptorin D 73069-28-0 Praeruptorin D, a natural product isolated and purified from the roots of Peucedanum praeruptorum Dunn., can significantly inhibit the infiltration of activated polymorphonuclear leukocytes (PMNs) and decrease the levels of TNF-α and IL-6 in bronchoalveolar lavage fluid at the same dose, suppresses LPS induced Nuclear Factor-kappa B (NF-κB) pathway activation in the lung by decreasing the cytoplasmic loss of inhibitor κB-α (IκB-α) protein and inhibiting the translocation of p65 from cytoplasm to nucleus.
CSN16616 Praeruptorin D 73069-28-0 Praeruptorin D, a natural product isolated and purified from the roots of Peucedanum praeruptorum Dunn., can significantly inhibit the infiltration of activated polymorphonuclear leukocytes (PMNs) and decrease the levels of TNF-α and IL-6 in bronchoalveolar lavage fluid at the same dose, suppresses LPS induced Nuclear Factor-kappa B (NF-κB) pathway activation in the lung by decreasing the cytoplasmic loss of inhibitor κB-α (IκB-α) protein and inhibiting the translocation of p65 from cytoplasm to nucleus.
CSN16138 Pimpinellin 131-12-4 Pimpinellin, a natural product isolated and purified from the fruits of Psoralea corylifolia L.
CSN13863 Phellopterin 2543-94-4 Phellopterin, a natural product isolated and purified from the roots of Saposhnikovia divaricata, is a partial agonist of the central benzodiazepine receptors in vitro, shows cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM, and reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium.
CSN14011 Phebalosin 6545-99-9 Phebalosin, a natural product isolated and purified from the herbs of Murraya exotica L., displays EC(50) of 14.1 mg/mL against axenic amastigote forms of Leishmania panamensis. and cytotoxicity (IC(50)) at concentrations of 20.7 mg/mL on human promonocytic U-937 cells.
CSN14017 Oxypeucedanin Hydrate 133164-11-1 Oxypeucedanin is a chemical constituent from polarity part in roots of Angelica dahurica var. formosana cv. Chuanbaizhi.
CSN14020 Osthol Hydrate 69219-24-5 Osthol is a natural product isolated and purified from the fructus of Cnidium monnieri (L.) Cusson.
CSN14004 Meranzin Hydrate 5875-49-0 Meranzin, a natural product isolated and purified from the roots of Angelica biserrata, produces a rapid effect mediated by AMPA receptors and involving BDNF modulation through the ERK1/2 pathway. Meranzin can also induce similar effect to Fructus Aurantii on intestinal motility and it was, at least in part, mediated by stimulation of H1 histamine receptors, and exhibits antidepressive and prokinetic-like effects through the regulation of the common mediator, the alpha 2-adrenoceptor , and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.
CSN14012 Meranzin 23971-42-8 Meranzin, a natural product isolated and purified from the peel of Citrus maxima, can induce similar effect to Fructus Aurantii on intestinal motility and it was, at least in part, mediated by stimulation of H1 histamine receptors.
CSN13967 Mellein 480-33-1 Mellein is a natural product isolated and purified from the herbs of Goniothalamus griffithii.
CSN14575 Marmin 14957-38-1 Marmin, a natural product isolated and purified from the herbs of Citrus maxima with potent anti-ulcer, antibacterial, fungicidal, and algicidal properties, can inhibit contraction of the guinea-pig tracheal smooth muscle, especially by interfering histamine receptor, inhibiting the histamine release from mast, inhibiting intracellular Ca2+ release from the intracellular store and the Ca2+ influx through voltage-dependent Ca2+ channels, is potential to develop as antihistamine agents, especially as histamine H1 receptor antagonists by interacting with amino acid residues, Asp107, Lys179, Lys191, Asn198, and Trp428 of histamine H1 receptor, shows a cell-growth inhibitory effect against L1210 and K562 in vitro.
CSN14575 Marmin 14957-38-1 Marmin, a natural product isolated and purified from the herbs of Citrus maxima with potent anti-ulcer, antibacterial, fungicidal, and algicidal properties, can inhibit contraction of the guinea-pig tracheal smooth muscle, especially by interfering histamine receptor, inhibiting the histamine release from mast, inhibiting intracellular Ca2+ release from the intracellular store and the Ca2+ influx through voltage-dependent Ca2+ channels, is potential to develop as antihistamine agents, especially as histamine H1 receptor antagonists by interacting with amino acid residues, Asp107, Lys179, Lys191, Asn198, and Trp428 of histamine H1 receptor, shows a cell-growth inhibitory effect against L1210 and K562 in vitro.
CSN10152 Isoscopoletin 776-86-3 Isoscopoletin is a natural product isolated and purified from the herbs of Paederia scandens (Lour.) Merr.
CSN10961 Isofraxidin 486-21-5 Isofraxidin, a natural product isolated and purified from the herbs of Sarcandra glabra (Thunb.) Nakai, possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2.
CSN13966 Heraclenol 31575-93-6 Heraclenol, a natural product isolated and purified from the herbs of Heracleum repula Franch, can inhibit the proliferation of melanoma cells and cell cycle.
CSN13981 Heraclenin 2880-49-1 Heraclenin, a natural product isolated and purified from the fruits of Citrus aurantium L., induces apoptosis in Jurkat leukemia cells in mechanistically different ways.
CSN11055 Fraxin 524-30-1 Fraxin protects HUVECs from oxidative stress, enhances urate excretion partly by inhibiting mURAT1 or mGLUT9 in kidney of hyperuricemic mice. It is a natural product isolated and purified from the bark of Fraxinus brngeana DC..
CSN11054 Fraxidin 525-21-3 Fraxidin is a natural product isolated and purified from the herbs of Sarcandra glabra.
CSN12630 Esculetin 305-01-1 Esculetin is a naturally occuring 5-lipoxygenase and 12-Lipoxygenase inhibitor with IC50 values of ID50 values of 4 and 2.5 µM, respectively.
CSN14019 Erythrocentaurin 50276-98-7 Erythrocentaurin is a hepatitis B virus inhibitor.
CSN10746 Daphnoretin 2034-69-7 Daphnoretin, a natural product isolated and purified from the roots of Wikstroemia indica (Linn.) C. A. Mey., has strong antiviral activity, mainly on the later phase of the replication cycle. Daphnoretin also has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells, might through promoting apoptosis in a mitochondria-mediated way.
CSN10701 Coumarin 91-64-5 Coumarin is a secondary phytochemical isolated and purified from the herbs of Melilotus officinalis with hepatotoxic and carcinogenic properties.
CSN19958 Columbianadin 5058-13-9 Columbianadin, a natural product isolated and purified from the herbs of Angelicae pubescens with analgesic, anti-inflammatory, calcium-channel blocking, and platelet aggregation inhibiting functions, can effectively suppress the growth of colon cancer cells, low concentration (up to 25 μM) of CBN induces apoptosis, and high concentration (50 μM) of CBN induces necroptosis, demonstrates that CBN has the potential to be a candidate in the development of anti-cancer agent derived from natural products.
CSN13447 Chloculol 131652-35-2 Chloculol is a natural product.
CSN10419 Bergaptol 486-60-2 Bergaptol is a hydroxylated psoralen isolated and purified from the root of Notopterygium incisum that acts as a potent inhibitor of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 μM.
CSN14218 Auraptenol 1221-43-8 Auraptenol, a natural product isolated and purified from the fruits of Citrus aurantium with robust antidepressant-like efficacy in mice.
CSN13219 8-Geranyloxy-5,7-Dimethoxycoumarin 1228175-65-2 8-Geranyloxy-5,7-dimethoxycoumarin is a natural product isolated and purified from the herbs of Toddalia asiatica with antidiabetic and antioxidant effect.
CSN13043 7-Hydroxy-6-Methoxy-3-Prenylcoumarin 299159-90-3 7-Hydroxy-6-methoxy-3-prenylcoumarin is a natural product isolated and purified from the herbs of Coriaria nepalensis.
CSN13397 7-Hydroxy-3-Prenylcoumarin 86654-26-4 7-Hydroxy-3-prenylcoumarin is a natural product isolated and purified from the herbs of Coriaria nepalensis.
CSN13282 7-Geranyloxy-6-Methoxycoumarin 28587-43-1 7-Geranyloxy-6-methoxycoumarin is a natural product isolated and purified from the herbs of Murraya tetramera Huang, showing significant cytotoxicity against three cell lines (A549, SMMC-7721 and BALL-1).
CSN10955 7-Amino-4-Methylcoumarin 26093-31-2 7-Amino-4-methylcoumarin is a natural product isolated and purified from an endophytic Xylaria fungal species and exhibited strong antibacterial and antifungal activities in vitro against Aspergillus, Candida, Escherichia, Staphylococcus, Salmonella and Vibrio species, among others. It is also a reagent employed in the preparation of fluorogenic AMC-based substrates for the detection of proteolytic enzyme activity. AMC has been utilized as a fluorescent probe to analyze glycoproteins' monosaccharides and N-linked oligosaccharides via chromatography and has been used as a laser dye.
CSN11536 5-Methoxypsoralen 484-20-8 5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation [psoralen plus UV (PUVA)] to manage psoriasis and vitiligo and inhibits proliferation in the human hepatocellular carcinoma cell line.
CSN13341 5,7,8-Trimethoxycoumarin 60796-65-8 5,7,8-Trimethoxycoumarin is a natural product isolated and purified from the herbs of Viola yedonensis Makino.
CSN13327 5,6,7,8-Tetramethoxycoumarin 56317-15-8 5,6,7,8-Tetramethoxycoumarin is a natural product isolated and purified from the herbs of Croton laevigatus.
CSN13076 4-Methylumbelliferone 90-33-5 4-Methylumbelliferone, a natural product isolated and purified from the herbs of Ruta graveolens L., is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.
CSN19953 (±)-Praeruptorin A 73069-25-7 (±)-Praeruptorin A, a natural product isolated and purified from the roots of Peucedanum praeruptorum Dunn., can exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation, has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis, and can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro.
CSN13223 (S)-Yuehgesin C 125072-68-6 (S)-Yuehgesin C is a natural product isolated and purified from the herbs of Murraya paniculata.
CSN14047 (-)-Praeruptorin B 4970-26-7 (-)-Praeruptorin B is a natural product isolated and purified from Peucedani Radix.
CSN14015 (-)-Praeruptorin A 14017-71-1 (-)-Praeruptorin A, a natural product isolated and purified from the herbal medicine Peucedanum praeruptorum, inhibits in vitro migration of preosteoclasts and in vivo bone erosion, possibly due to its potential to target calmodulin.
CSN14018 (-)-Heraclenol 139079-42-8 (-)-Heraclenol is a natural product isolated and purified from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi.
CSN13983 (+)-Mellein 62623-84-1 (+)-Mellein is a natural product isolated and purified from the herbs of Goniothalamus griffithii.
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