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Androgen Receptor

Androgen Receptor

货号 产品名 CAS号 信息
CSN21357 YK11 1370003-76-1 YK11 is a partial agonist of androgen receptor, with osteogenic activity.
CSN12743 RU 58841 154992-24-2 RU 58841 is a nonsteroidal antiandrogen for potential use as a topical treatment for androgen-dependent conditions including acne, pattern hair loss, and excessive hair growth.
CSN19838 RD162 915087-27-3 RD 162 is an orally active and very potent antagonist of androgen receptor (AR) and is a second-generation of antiandrogen for the treatment of advanced prostate cancer and highly recommended tool in AR research.
CSN27359 Ralaniten triacetate 1637573-04-6 Ralaniten triacetate (EPI-506), the pro-drug of Ralaniten, is a first-in-class, orally active androgen receptor (AR) N-terminal domain (NTD) inhibitor. Ralaniten triacetate shows activity against both full length and resistance-related AR species, including AR-v7.
CSN16396 Protodioscin 55056-80-9 Protodioscin, a major steroidal saponin in dioscoreae rhizome, has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties. Protodioscin is able to stimulate testosterone production and it also has an androgen-mimetic action, binding and activating the testosterone receptors.
CSN27360 N-Propyl-N-(2-(2,4,6-trichlorophenoxy)ethyl)-1H-imidazole-1-carboxamide 67747-09-5 Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. Prochloraz inhibits human placenta microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an antagonist of the estrogen receptor (ER) and androgen receptor (AR) (IC50s = 25 μM and 4 μM, respectively) as well as activates the aryl hydrocarbon receptor (AhR; EC50 = 1 μM).
CSN17663 ORM-15341 1297537-33-7 ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct.
CSN17664 N-((S)-1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide 1297538-32-9 ODM-201 is a competitive inhibitor of androgen receptor with IC50 value of 26 nM and inhibits AR nuclear translocation with Ki value of 11 nM.
CSN16774 Nilutamide 63612-50-0 Nilutamide is a non-steroidal androgen receptor antagonist and also inhibits androgen biosynthesis in vitro.
CSN17614 N-desmethyl Enzalutamide 1242137-16-1 N-Desmethyl enzalutamide is a major metabolite of Enzalutamide, Enzalutamide (MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM.
CSN18357 MK-0773 606101-58-0 MK-0773, one of selective androgen receptor modulators (SARMs), is a 4-aza-steroid that exhibited tissue selectivity in humans (IC50= 6.6 nM).
CSN11374 (8R,9S,10R,13S,14S,17R)-17-Acetyl-6,10,13-trimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate 595-33-5 Megestryl Acetate is a synthetic progesterone analog.
CSN10977 Hydroxyflutamide 52806-53-8 Hydroxyflutamide is a derivative of the synthetic steroid ethisterone, that suppresses the production of gonadotrophins, and has some weak androgenic effects.
CSN18667 GSK-2881078 1539314-06-1 GSK 2881078 is a selective androgen receptor modulator potentially for the treatment of cachexia.
CSN17573 GLPG0492 (R enantiomer) 1215085-93-0 GLPG0492 R-enantiomer is the R-Enantiomer of GLPG-0492, which is a selective androgen receptor modulator.
CSN17572 GLPG0492 1215085-92-9 GLPG0492 is a selective androgen receptor modulator and exhibits anabolic activity on muscle, strongly dissociated from the androgenic activity on prostate after oral dosing.
CSN16707 Flutamide 13311-84-7 Flutamide is a competitive non-steroidal antagonist of androgen receptor.
CSN10468 EPI-001 227947-06-0 EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ∼6 μM and a selective PPAR-gamma modulator.
CSN12389 4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide 915087-33-1 Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells.
CSN21418 DNA (Terrabacter strain YK11 16S rRNA gene fragment) 431579-34-9 DNA (Terrabacter strain YK11 16S rRNA gene fragment) is a selective androgen receptor modulator (SARM).
CSN10728 Cyproterone acetate 427-51-0 Cyproterone Acetate is an antagonist and partial agonist of androgen receptor with IC50 value of 7.1 nM and EC50 value of 4μM.
CSN18075 Cortexolone 17 alpha-propionate 19608-29-8 Cortexolone 17 alpha-propionate is a topical and peripherally selective androgen antagonist, which is used in treatment of acne and androgenic alopecia.
CSN16582 BMS-564929 627530-84-1 BMS-564929 is an androgen receptor (AR) agonist, binds to androgen receptor (AR) with a Ki of 2.11±0.16 nM.
CSN12437 Bicalutamide 90357-06-5 Bicalutamide is non-steroidal androgen receptor antagonist with IC50 value of 190 nM.
CSN17150 AZD3514 1240299-33-5 AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.
CSN17338 Dimethylcurcumin 52328-98-0 ASC-J9, an antitumor agent, suppresses castration-resistant prostate cancer growth via degradation of full-length and splice variant androgen receptors.
CSN28405 N-(trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)pyridazine-3-carboxamide 2222112-77-6 ARV-110 is an orally active, specific androgen receptor PROTAC degrader with DC50 < 1nM.
CSN13830 4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide 956104-40-8 ARN-509 can compeitively and selectively inhibit androgen receptor with IC50 value of 16 nM.
CSN28523 ARD-69 2316837-10-0 ARD-69 is a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. ARD-69 induces degradation of AR protein in AR-positive prostate cancer cell lines in a dose- and time-dependent manner. ARD-69 achieves DC50 values of 0.86, 0.76, and 10.4 nM in LNCaP, VCaP, and 22Rv1 AR+ prostate cancer cell lines, respectively. ARD-69 is capable of reducing the AR protein level by >95% in these prostate cancer cell lines and effectively suppressing AR-regulated gene expression.
CSN26635 ARCC-4 1973403-00-7 ARCC-4 is a PROTAC, acting as an androgen receptor degrader. ARCC-4 is a low-nanomolar androgen receptor degrader able to degrade about 95% of cellular androgen receptors. ARCC-4 inhibits prostate tumor cell proliferation, degrades clinically relevant androgen receptor point mutants and unlike enzalutamide, retains antiproliferative effect in a high androgen environment. Thus, ARCC-4 exemplifies how protein degradation can address the drug resistance hurdles of enzalutamide.
CSN20433 Androgen Receptor Modulator C7 2109805-69-6 Androgen receptor modulator C7 is a potent AR (ARE EC50 = 0.34 nM) and tissue-selective (N/C interaction EC50 = 1206 nM) modulator.
CSN22336 ACP-105 899821-23-9 ACP-105 is a potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone.
CSN19392 3,3'-Diindolylmethane 1968-05-4 3,3'-Diindolylmethane is an AR structurally similar androgen receptor antagonist.
CSN23255 Fenipentol 583-03-9 1-Phenylpentan-1-ol is an intermediate for synthesis of β-amino-carbonyl-based androgen receptor antagonist.
CSN39351 Cyprodinil 121552-61-2
CSN37242 11-Ketodihydrotestosterone 32694-37-4
CSN81050 Cyprodinil-13C6 1773496-63-1
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