|(2S,2'S,3R,3'R,4R,4'R,5R,5'R,6S,6'S)-6,6'-(((2R,3R,4S,5S,6R)-4-羟基-2-(((4S,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-10-羟基-6a,8a,9-三甲基-10-((R)-3-甲基-4-(((2R,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)丁基)-3,4,5,6,6a,6b,7,8,8a,8b,9,10,11a,12,12a,12b-十六氢-1H-萘并[2',1':4,5]茚并[2,1-b]呋喃-4-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,5-二基)双(氧基))双(2-甲基四氢-2H-吡喃-3,4,5-三醇)|CsnPharm

CAS No.: 55056-80-9

Protodioscin/原薯蓣皂苷 Catalog No. CSN16396

Synonyms: Furostanol I;NSC 698796;原薯蓣皂苷

Protodioscin, a major steroidal saponin in dioscoreae rhizome, has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties. Protodioscin is able to stimulate testosterone production and it also has an androgen-mimetic action, binding and activating the testosterone receptors.

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生物活性

描述Protodioscin, a major steroidal saponin in dioscoreae rhizome, has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties. Protodioscin (5 and 10 mg/kg) significantly improves glucose intolerance and reduced the levels of serum UA, BUN, Cr, TC (serum uric acid, blood urea nitrogen, creatinine, total cholesterol, triglyceride) and TG. Protodioscin significantly reduces renal concentrations of IL-1β, IL-6 and TNF-α by inhibiting the activation of nuclear factor-κB, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase and extracellular signal-regulated kinase^[3]. PD (Protodioscin) inhibits cell viability, causes a loss of mitochondrial function, and induces apoptosis, as evidenced by up-regulation of caspase-8, -3, -9, -PARP, and Bax activation, and down-regulation of Bcl-2 expression. PD was shown to induce ROS and the ER stress pathway, including GRP78, p-eIF-2α, ATF4, and CHOP^[4]. Protodioscin ameliorates the death rate, inhibits the increase in neurological deficit scores and infarct volume, and reduces the apoptotic nerve cells induced by MCAO (middle cerebral artery occlusion) in rats. Protodioscin attenuates the change of relevant apoptins, suppresses the release of pro-inflammatory cytokines in serum and reverses the protein expression of NF-κB (in nucleus and cytoplasm) and IκBα (in cytoplasm) induced by MCAO in rats^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01971099	Hypoactive Sexual Desire Disfu... more >>nction Collapse <<	Phase 4	Completed	-	Brazil ... more >> Hospital das Clinicas - Universidade Federal de Minas Gerais Belo Horizonte, Minas Gerais, Brazil, 30130100 Collapse <<
NCT02748005	Hypogonadism	Not Applicable	Completed	-	India ... more >> Saroj Hospital & Maternity Centre Kanpur Hardoi Ring Road, Para,Lucknow, U P, India, 226017 Collapse <<
NCT02702882	Hypogonadism	Not Applicable	Completed	-	India ... more >> Department of Urology, King George's Medical University, Lucknow, UP, India Lucknow, Uttar Pradesh, India, 226003 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.9531 mL
- 4.7655 mL
- 9.5311 mL
- 5 mM
- 0.1906 mL
- 0.9531 mL
- 1.9062 mL
- 10 mM
- 0.0953 mL
- 0.4766 mL
- 0.9531 mL

技术信息

CAS号

55056-80-9

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C51H84O22

运输

蓝冰

分子量

1049.20

别名

Furostanol I;NSC 698796;原薯蓣皂苷

溶解度

DMSO	340.0 mg/mL (324.1 mM)
Water	88.0 mg/mL (83.9 mM) warming

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