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NLR

NLR

货号 产品名 CAS号 信息
CSN33194 Dapansutrile 54863-37-5 OLT1177, a β-sulfonyl nitrile molecule, is a selective inhibitor of the NLRP3 inflammasome, with unique properties to reverse the metabolic costs of inflammation and to treat IL-1β– and IL-18–mediated diseases.
CSN18850 NOD-IN-1 132819-92-2 NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.
CSN16516 Nodinitib-1 799264-47-4 ML130 is a selective and potent NOD1 inhibitor with IC50 of 560 nM. It inhibits NOD1-induced NF-κB activation.
CSN18163 MCC950 sodium 256373-96-3 MCC950 Sodium is a potent and highly specific small molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 nM in BMDMs.
CSN18104 MCC950 210826-40-7 MCC950 is a potent, selective, small-molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs.
CSN22257 INF39 866028-26-4 INF39 is an irreversible NLRP3 inhibitor with IC50 value of ~100 μM for inhibiton of NLRP3 ATPase, which can inhibit IL-1β release, caspase activation and pyroptosis in THP-1 cells.
CSN27580 GSK717 1595278-21-9 GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells .
CSN21903 5-Chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide 16673-34-0 Glibenclamide impurity A is an inhibitor of the formation of the NLRP3 inflammasome in cardiomyocytes.
CSN21218 CY-09 1073612-91-5 CY-09 can inhibit NLRP3 with Kd value of 500 nM through directly bounding to the ATP-binding site of the NLRP3 NACHT domain.
CSN25202 1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one 18956-16-6 Cardamonin (Cardamomin), a natural flavone isolated from Alpinia katsumadai Hayata, acts as an aryl hydrocarbon receptor (AhR) activator. Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway .
CSN33192 Fc 11a-2 960119-75-9
CSN33191 JC124 1638611-48-9
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