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AX-024 HCl can inhibit cytokine release especially the production of IL-6, TNFα, IFN-γ, IL-10 and IL-17A. It also modulates TCR signaling and prevents psoriasis and asthma.
IFN alpha-IFNAR-IN-1 HCl is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR and inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 μM).
BMS-986165 is a highly selective and allosteric TYK2 inhibitor. It is a high affinity JH2 ligand with Ki values of 0.02 nM and 1nM for binding to Tyk2 pseudokinase domain and JAK1 pseudokinase (JH2) domain, respectively. It blocked receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain.
Tags: 干扰素受体 | IFNAR | 免疫/炎症 | Immunology/Inflammation | 干扰素受体 相关产品
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