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ALDH

ALDH

货号 产品名 CAS号 信息
CSN24614 N,N'-(Octane-1,8-diyl)bis(2,2-dichloroacetamide) 1477-57-2 WIN 18446 is an inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) with IC50 of 0.3 μM.
CSN15746 NCT-501 1802088-50-1 NCT-501 is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 > 57 μM).
CSN10460 Bis(diethylthiocarbamoyl) disulfide 97-77-8 Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram acts as an allosteric inhibitor of MERS-CoV PLpro but as a competitive (or mixed) inhibitor of SARS-CoV PLpro. It also inhibits pyroptosis by blocking gasdermin D pore formation.
CSN16397 3-(4-Hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one 552-66-9 Daidzin can inhibit mitochondrial aldehyde dehydrogenase2 with IC50 of 80 nM and ALDH-I selectively (Ki=20 nM). Daidzin is purified from the root of Pueraria lobata with effective anti-atherosclerotic activities.
CSN22782 CVT-10216 1005334-57-5 CVT 10216 is a potent and selective aldehyde dehydrogenase-2 (ALDH2) inhibitor with IC50s of 29 and 1300 nM for ALDH2 and ALDH1, respectively.
CSN25276 CM10   692269-09-3 CM10 is an ALDH1A inhibitor that depletes CD133+ cancer stem cells.
CSN18233 N-(Benzo[d][1,3]dioxol-5-ylmethyl)-2,6-dichlorobenzamide 349438-38-6 Alda-1 is an ALDH2 agonist, cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).
CSN23590 3,4-Dihydroxyphenylacetic acid 102-32-9 3,4-Dihydroxyphenylacetic Acid is a metabolite of dopamine, it can modulate the aldehyde dehydrogenase (ALDH) activity and protects the cells from the acetaldehyde-induced cytotoxicity in vitro.
CSN22659 CM037 896795-60-1
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