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Trk Receptor

Trk Receptor

货号 产品名 CAS号 信息
CSN20508 TrkA Inhibitor C6t 1377503-70-2 TrkA inhibitor C6t is a potent and selective TrkA inhibitor (IC50=1.67 nM) showing activity in cellular proliferation and apoptosis assays and exhibiting antiangiogenic activity.
CSN20509 Trk Inhibitor C11 1614229-04-7 Trk inhibitor C11 is an orally active pan-Trk inhibitor showing efficacy in both inflammatory and neropathic pain models.
CSN20506 PF-06273340 1402438-74-7 PF-06273340 is a potent, selective and orally bioavailable pan-Trk inhibitor (IC50 values are 1, 2 and 6 nM for Trk C, B and A, respectively). It is peripherally restricted and exhibits efficacy in a rodent model of inflammatory pain.
CSN23684 Loxo-195   2097002-61-2 LOXO-195 is a TRK kinase inhibitor (TKI) with IC50 values of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively.
CSN17586 LOXO-101 Sulfate 1223405-08-0 LOXO-101 sulfate blocks the ATP binding site of the TRK family of receptors with IC50 of 2 nM to 20 nM against TRKA, TRKB, and TRKC.
CSN16968 LOXO-101 1223403-58-4 LOXO-101 is an ATP-competitive inhibitor of TRK with IC50 of nanomolar range for all the family members.
CSN22901 LM22B-10 342777-54-2 LM22B-10 is an agonist of TrkB and TrkC neurotrophin receptor. It can improve survival and increase neurite outgrowth in vitro.
CSN15969 LM22A-4 37988-18-4 LM22A-4 is a specific agonist oftyrosine kinase receptor B.
CSN13940 GW441756 504433-23-2 GW 441756 is an inhibitor of tropomyosin-related kinase A (TrkA) with IC50 of 2 nM.
CSN15870 GNF-5837 1033769-28-6 GNF-5837 is a potent pan-Trk inhibitor which display antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively).
CSN20507 GNF-8625 1196546-33-4 GNE-8525 is a potent and selective pan-TRK inhibitor, demonstrated potent antiproliferation activity with IC50 = 0.003 μM. In a tumor xenograft model derived from the KM12 cell line, GNE-8525 demonstrated in vivo antitumor efficacy when administered at ascending doses twice daily (bid) for 14 days in rats.
CSN22174 CE-245677 717899-97-3 CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.
CSN22125 AZ-23 915720-21-7 AZ-23 is a potent, orally bioavailable Trk kinase inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively.
CSN15752 ANA-12 219766-25-3 ANA-12 is antagonist of TrkB with Kd of 10 nM.
CSN10171 7,8-Dihydroxyflavone 38183-03-8 7,8-Dihydroxyflavone acts as an agonist of TrkB receptor with Kd of 320 nM with neuroprotective effect.
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