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IAP

IAP

货号 产品名 CAS号 信息
CSN16489 UC-112 383392-66-3 UC-112 is a potent IAP (Inhibitor of apoptosis) inhibitor, and potently inhibits cell growth in two human melanoma (A375 and M14) and two human prostate (PC-3 and DU145) cancer cell lines (IC50=0.7-3.4 μM).
CSN18637 SM-164   957135-43-2 SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respectively.
CSN17158 LCL161 1005342-46-0 LCL161 is an IAP inhibitor, inhibits XIAP activity in HEK293 cell with IC50 of 35 nM, also inhibits cIAP1 activity in MDA-MB-231 cell with IC50 of 0.4 nM.
CSN18513 GDC-0152 873652-48-3 GDC-0152 is a potent inhibitor of IAPs and binds to the XIAP BIR3 domain, the BIR domain of ML-IAP, and the BIR3 domains of cIAP1 and cIAP2 with K (i) values of 28, 14, 17, and 43 nM, respectively.
CSN10903 Embelin 550-24-3 Embelin, a quinone isolated from the Japanese Ardisia herb, is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 μM in a cell-free assay.
CSN17869 CUDC-427 1446182-94-0 CUDC-427 is a small-molecule peptide mimetic of SMAC/DIABLO and directly antagonizes inhibitors of apoptosis proteins (IAPs).
CSN17381 BV-6 1001600-56-1 BV6 is a small-molecule Smac mimetic, which antagonizes IAP and induces autoubiquitination and subsequent proteasomal degradation of cIAP1 and cIAP2.
CSN19202 BV-6 Trifluoroacetate N/A BV-6 trifluoroacetate is a SMAC mimetic, dual cIAP and XIAP inhibitor.
CSN17633 AZD5582 1258392-53-8 AZD5582 is a class of dimeric Smac mimetics as potent IAP antagonist and binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP (IC50 = 15, 21, and 15 nM, respectively).
CSN15873 AT406 1071992-99-8 AT406 is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs), AT-406 binds to XIAP, cIAP1, and cIAP2 proteins with K (i) of 66.4, 1.9, and 5.1 nM, respectively.
CSN20155 AT-IAP 1403898-55-4 AT-IAP is a potent, orally bioavailable, dual antagonist of XIAP and cIAP1 which is functioning in anti-apoptotic and pro-survival signaling pathways.
CSN21085 ASTX660 1799328-86-1
CSN17636 Birinapant 1260251-31-7
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