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ATP Citrate Lyase

ATP Citrate Lyase

货号 产品名 CAS号 信息
CSN24799 NDI-091143 2375840-87-0 NDI-091143 is a small-molecule inhibitor of human ACLY. It is located in an allosteric, mostly hydrophobic cavity next to the citrate-binding site, and requires extensive conformational changes in the enzyme that indirectly disrupt citrate binding.
CSN12153 Hydroxycitric Acid 6205-14-7 Hydroxycitric acid, a natural product isolated and purified from the fruits of Garcinia atroviridis, can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis, and ameliorate high-fructose-induced redox imbalance and activation of stress sensitive kinases in male Wistar rats through its hypolipidemic effects.
CSN18618 BMS-303141 943962-47-8 BMS-303141 is a potent ATPcitrate lyase (ACL) inhibitor with IC50 of 0.13 μM (human recombinant ACL).
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