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HIF

HIF

货号 产品名 CAS号 信息
CSN18648 Vadadustat 1000025-07-9 Vadadustat is used for treatment of anemia and chronic kidney disease by Leading to stabilization and increased levels of HIFα and improving production of hemoglobin and red blood cells (RBCs) while maintaining normal levels of erythropoietin (EPO).
CSN24188 TP0463518 1558021-37-6 TP0463518 is a potent HIF-PHD inhibitor with Ki value of 5.3 nM for PHD2, and also inhibited human PHD1/3 with IC50 values of 18 and 63 nM.
CSN18362 THS-044 62054-67-5 THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings.
CSN19042 SYP-5 1384268-04-5 SYP-5 is a HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis.
CSN18393 PX-478 Dihydrobromide 685898-44-6 PX-478 target on HIF-1α, which can selectively inhibit the hypoxia-induced increase in HIF-1a protein.
CSN17993 PT-2385 1672665-49-4 PT2385 is an inhibitor of hypoxia inducible factor (HIF)-2 alpha with antineoplastic effect.
CSN17994 PT-2385 R-Enantiomer 1672666-67-9 PT-2385 R-enantiomer is the R-enantiomer of PT-2385, which is a potent HIF-2α inhibitor and is a potential anticancer agent.
CSN20370 PHD-1 Inhibitor C54 2009344-53-8 PHD-1 inhibitor C54 is a 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1). It exhibits reasonable peripheral exposure but poor brain levels (Kp,uu 0.02 and B/P 0.03).
CSN20369 PHD-1 Inhibitor C53 2009345-20-2 PHD-1 inhibitor C53 is a 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1). It exhibits excellent peripheral exposure, but does not partition well into the brain (Kp,uu 0.39 and B/P 0.21).
CSN20368 PHD-1 Inhibitor C39 2009343-19-3 PHD-1 inhibitor C39 is a 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1) with high solubility and permeability.
CSN20367 PHD-1 Inhibitor C17 2009343-14-8 PHD-1 inhibitor C17 is an early lead compound of 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitors of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1) showing a moderate rate of microsomal turnover in vitro.
CSN11607 Oltipraz 64224-21-1 Oltipraz can inhibit the insulin-activated HIF-1α (IC50 = 10 µM) in a time-dependent manner.
CSN14671 Moracin O 123702-97-6 Moracin O and moracin P exhibit potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia.
CSN16868 Molidustat     1154028-82-6 Molidustat is a potent HIF-PH inhibitor with IC50 values of 480nM, 280nM and 450nM for PHD1, PHD2 and PHD3 (measured by the recombinant enzyme activity), respectively.
CSN16636 ML228 1357171-62-0 ML228 is an activator of the Hypoxia Inducible Factor (HIF) pathway and potently activate HIF in vitro as well as its downstream target VEGF.
CSN19680 MK-8617 1187990-87-9 MK-8617 is a potent, selective, orally bioavailabl pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively.
CSN20474 LW6 934593-90-5 LW6 is a HIF-1 inhibitor with an IC50 of 4.4 μM.
CSN17251 KC7F2 927822-86-4 KC7F2 is a selective HIF-1α transcription inhibitor with IC50 of 20 μM in a cell-based assay.
CSN17541 JNJ-42041935 1193383-09-3 JNJ-42041935 is a selective inhibitor of prolyl hydroxylase (PHD) with the pKis of 7.91 ± 0.04, 7.29 ± 0.05, and 7.65 ± 0.09 for PHD1, PHD2, and PHD3, respectively.
CSN16064 IOX2 931398-72-0 IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) Prolyl-Hydroxylases (PHD), and active in cells with IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH(20uM).
CSN20256 IDF-11774 1429054-28-3 IDF-11774 is a hypoxia-inducible factor (HIF)-1α inhibitor which regulates cancer metabolism, thereby suppressing tumor growth.
CSN18038 HIF-2α-IN-1 1799948-06-3 HIF-2α-IN-1 is a HIF-2α inhibitor has an IC50 of less than 500 nM in HIF-2α scintillation proximity assay.
CSN20613 GSK360A 931399-19-8 GSK360A is an active HIF-PHD inhibitor with systemic and local effects by stabilizing HIF-1α signaling and can improve long-term ventricular function.
CSN16228 FG-4592 808118-40-3 FG-4592 (Roxadustat) is the second generation HIF-PH inhibitor.
CSN16866 FG-2216 223387-75-5 FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 μM for PHD2 enzyme, orally bioavailable and induced significant and reversible Epo induction in vivo.
CSN22394 Enarodustat 1262132-81-9 Enarodustat is a potent and orally active factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM; Enarodustat has entered clinical trial for renal anemia.
CSN17599 EL-102 1233948-61-2 EL102 is an inhibitor of HIF1α , Which can inhibit tubulin polymerisation and decreased microtubule stability.
CSN20491 Echinomycin 512-64-1 Echinomycin is a highly potent and selective HIF-1α inhibitor (IC50 = 29.4 pM) which selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB.
CSN10851 DMOG   89464-63-1 Dimethyloxallyl glycine is a cell permeable, competitive inhibitor of HIF-PH (HIF-1α prolyl hydroxylase).
CSN17258 Daprodustat 960539-70-2 Daprodustat is a potent HIF-PH with IC50 values of 3.5nM, 22.2nM and 5.5nM for PHD1, PHD2 and PHD3, respectively.
CSN16738 Ciclopirox 29342-05-0 Ciclopirox inhibits iron-dependent enzymes PHD2 (pIC50 = 5.8) and deoxyhypusine hydroxylase. It is an antifungal and iron-chelating agent.
CSN19222 Chetomin 1403-36-7 Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1,disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
CSN17588 BAY 87-2243   1227158-85-1 BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced HIF-1 activation.
CSN19253 2-Methoxyestradiol   362-07-2 2-methoxyestradiol is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration.
CSN23782 Desidustat 1616690-16-4
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