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HIF

HIF

货号 产品名 CAS号 信息
CSN24188 TP0463518 1558021-37-6 TP0463518 is a potent HIF-PHD inhibitor with Ki value of 5.3 nM for PHD2, and also inhibited human PHD1/3 with IC50 values of 18 and 63 nM.
CSN18362 THS-044 62054-67-5 THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings.
CSN19042 SYP-5 1384268-04-5 SYP-5 is a HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis.
CSN18393 PX-478 Dihydrobromide 685898-44-6 PX-478 target on HIF-1α, which can selectively inhibit the hypoxia-induced increase in HIF-1a protein.
CSN17993 PT-2385 1672665-49-4 PT2385 is an inhibitor of hypoxia inducible factor (HIF)-2 alpha with antineoplastic effect.
CSN17994 PT-2385 R-Enantiomer 1672666-67-9 PT-2385 R-enantiomer is the R-enantiomer of PT-2385, which is a potent HIF-2α inhibitor and is a potential anticancer agent.
CSN20370 PHD-1 Inhibitor C54 2009344-53-8 PHD-1 inhibitor C54 is a 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1). It exhibits reasonable peripheral exposure but poor brain levels (Kp,uu 0.02 and B/P 0.03).
CSN20369 PHD-1 Inhibitor C53 2009345-20-2 PHD-1 inhibitor C53 is a 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1). It exhibits excellent peripheral exposure, but does not partition well into the brain (Kp,uu 0.39 and B/P 0.21).
CSN20368 PHD-1 Inhibitor C39 2009343-19-3 PHD-1 inhibitor C39 is a 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1) with high solubility and permeability.
CSN20367 PHD-1 Inhibitor C17 2009343-14-8 PHD-1 inhibitor C17 is an early lead compound of 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitors of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1) showing a moderate rate of microsomal turnover in vitro.
CSN11607 Oltipraz 64224-21-1 Oltipraz can inhibit the insulin-activated HIF-1α (IC50 = 10 µM) in a time-dependent manner.
CSN14671 Moracin O 123702-97-6 Moracin O and moracin P exhibit potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia.
CSN16636 ML228 1357171-62-0 ML228 is an activator of the Hypoxia Inducible Factor (HIF) pathway and potently activate HIF in vitro as well as its downstream target VEGF.
CSN19680 MK-8617 1187990-87-9 MK-8617 is a potent, selective, orally bioavailabl pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively.
CSN20474 LW6 934593-90-5 LW6 is a HIF-1 inhibitor with an IC50 of 4.4 μM.
CSN17251 KC7F2 927822-86-4 KC7F2 is a selective HIF-1α transcription inhibitor with IC50 of 20 μM in a cell-based assay.
CSN17541 JNJ-42041935 1193383-09-3 JNJ-42041935 is a selective inhibitor of prolyl hydroxylase (PHD) with the pKis of 7.91 ± 0.04, 7.29 ± 0.05, and 7.65 ± 0.09 for PHD1, PHD2, and PHD3, respectively.
CSN16064 IOX2 931398-72-0 IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) Prolyl-Hydroxylases (PHD), and active in cells with IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH(20uM).
CSN20256 IDF-11774 1429054-28-3 IDF-11774 is a hypoxia-inducible factor (HIF)-1α inhibitor which regulates cancer metabolism, thereby suppressing tumor growth.
CSN18038 HIF-2α-IN-1 1799948-06-3 HIF-2α-IN-1 is a HIF-2α inhibitor has an IC50 of less than 500 nM in HIF-2α scintillation proximity assay.
CSN20613 GSK360A 931399-19-8 GSK360A is an active HIF-PHD inhibitor with systemic and local effects by stabilizing HIF-1α signaling and can improve long-term ventricular function.
CSN16866 FG-2216 223387-75-5 FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 μM for PHD2 enzyme, orally bioavailable and induced significant and reversible Epo induction in vivo.
CSN22394 Enarodustat 1262132-81-9 Enarodustat is a potent and orally active factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM; Enarodustat has entered clinical trial for renal anemia.
CSN17599 EL-102 1233948-61-2 EL102 is an inhibitor of HIF1α , Which can inhibit tubulin polymerisation and decreased microtubule stability.
CSN20491 Echinomycin 512-64-1 Echinomycin is a highly potent and selective HIF-1α inhibitor (IC50 = 29.4 pM) which selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB.
CSN10851 DMOG   89464-63-1 Dimethyloxallyl glycine is a cell permeable, competitive inhibitor of HIF-PH (HIF-1α prolyl hydroxylase).
CSN16738 Ciclopirox 29342-05-0 Ciclopirox inhibits iron-dependent enzymes PHD2 (pIC50 = 5.8) and deoxyhypusine hydroxylase. It is an antifungal and iron-chelating agent.
CSN19222 Chetomin 1403-36-7 Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1,disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
CSN17588 BAY 87-2243   1227158-85-1 BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced HIF-1 activation.
CSN19253 2-Methoxyestradiol   362-07-2 2-methoxyestradiol is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration.
CSN23782 Desidustat 1616690-16-4
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