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PARP

PARP

货号 产品名 CAS号 信息
CSN13593 XAV-939   284028-89-3 XAV-939 is a selective Wnt pathway β-catenin-mediated transcription inhibitor and axin stabilizing agent with IC50 values of 11 and 4 nM for the inhibition of TNKS1 and TNKS2, respectively.
CSN15823 WIKI4 838818-26-1 WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM) and inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM).
CSN12302 Veliparib   912444-00-9 Veliparib is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively.
CSN12301 Veliparib 2HCl 912445-05-7 Veliparib dihydrochloride is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively.
CSN17138 UPF-1069 1048371-03-4 UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM, which is ~27-fold selective against PARP1.
CSN13901 Rucaparib Phosphate 459868-92-9 Rucaparib phosphate is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains.
CSN13914 Rucaparib 283173-50-2 Rucaparib is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains.
CSN23902 RK-287107   2171386-10-8 RK-287107 is a novel tankyrase-specific inhibitor with IC50 values of 14.3 nM and 10.6 nM for tankyrase-1 and tankyrase-2, respectively.
CSN17163 PJ34 344458-19-1 PJ34 is a potent specific inhibitor of PARPl/2 with IC50 of 110 nM and 86 nM, respectively.
CSN13594 PJ34 HCl 344458-15-7 PJ34 HCl is a potent specific inhibitor of PARP-l/2 with IC50 of 110 nM and 86 nM.
CSN11806 Picolinamide 1452-77-3 Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
CSN12345 Olaparib   763113-22-0 Olaparib is a potent PARP inhibitor with IC50 of 5 and 1 nM for PARP1 and PARP2, respectively.
CSN19737 OL-1 2051582-06-8 OL-1 is a PARP1 inhibitor with apoptosis-inducing mechanisms in triple-negative breast cancer.
CSN13750 NVP-TNKS656 1419949-20-4 NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM, showing > 300 fold selectivity against PARP1 and PARP2.
CSN10181 NU1025 90417-38-2 NU1025 is a potent PARP inhibitor with IC50 of 400 nM.
CSN16905 MN-64 92831-11-3 MN-64 is an inhibitor of tankyrases, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
CSN17416 MK-4827 Tosylate 1038915-73-9 MK-4827 tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM and with great activity in cancer cells with mutant BRCA-1 and BRCA-2 and > 330-fold selective against PARP3, V-PARP and Tank1.
CSN21302 MK-4827 R-enantiomer 1038915-58-0 MK-4827 R-enantiomer is an excellent PARP1 inhibitor with IC50 of 2.4 nM.
CSN13146 MK-4827   1038915-60-4 MK-4827 is an excellent PARP1 and PARP2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively.
CSN17415 MK-4827 HCl 1038915-64-8 MK-4827 hydrochloride is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM, showing great activity in cancer cells with mutant BRCA-1 and BRCA-2, and is > 330-fold selective against PARP3, V-PARP and Tank1.
CSN19194 ME0328 1445251-22-8 ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
CSN19692 LT-626 1207456-03-8 LT-626 functions as an effective radiosensitizer during fractionated radiation treatment, leading to significant decrease in tumor burden and doubling the median survival.
CSN16009 JW 55 664993-53-7 JW 55 is a potent and selective β-catenin signaling pathway inhibitor, which functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). JW55 decreases auto-PARsylation of TNKS1/2 in vitro with IC50s of 1.9 μM and 830 nM respectively.
CSN17047 INO-1001 3544-24-9 INO-1001 is a potent inhibitor of PARP with IC50 of < 50 nM in CHO cells and a mediator of oxidant-induced myocyte dysfunction during reperfusion.
CSN24184 GeA-69 2143475-98-1 GeA-69 is a selective PARP14 inhibitor with Kd value of 2.1 µM, targeting on macrodomain 2.
CSN17770 G007-LK 1380672-07-0 G007-LK is a potent and selective tankyrase inhibitor with IC50 of 46 nM and 25 nM for TNKS1/2, respectively.
CSN17497 E-7449 1140964-99-3 E7449 is an orally bioavailable, potent, small molecule inhibitor of PARP1 and PARP2 and enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors.
CSN12304 BSI-201 160003-66-7 BSI-201 is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC).
CSN15885 BMN-673   1207456-01-6 BMN-673 is a PARP1/2 inhibitor with IC50 of 0.57 nM for PARP1.
CSN16087 BMN-673 8R,9S 1207456-00-5 BMN-673 8R,9S is an enantiomer of BMN-673, which is a PARP1/2 inhibitor with IC50 of 0.57 nM for PARP1.
CSN12830 BGP-15 66611-37-8 BGP-15, is a nicotinic amidoxime derivative with PARP inhibitory activity. It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury.
CSN21993 Pamiparib 1446261-44-4 BGB-290 shows potent DNA-trapping activity with IC50 of 13 nM. In the cellular assays, BGB-290 inhibits intracellular PAR formation with an IC50 of 0.24 nM.
CSN10401 Benzamide 55-21-0 Benzamide, an inhibitor of poly (ADP-ribose) polymerase, is a derivative of benzoic acid.
CSN16496 AZD2461 1174043-16-3 AZD2461 is a PARP inhibitor, which has the potential to avoid the olaparib resistence mediated by Pgp.
CSN17985 AZ6102 1645286-75-4 AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells.
CSN18861 AZ1366 1645286-58-3 AZ1366 inhibits tankyrase as a cotreatment strategy with EGFR inhibition in an identifiable subset of EGFR-driven NSCLC.
CSN17188 AG-14361 328543-09-5 AG14361 is a potent inhibitor of PARP1 with Ki of < 5 nM.
CSN16464 A-966492 934162-61-5 A-966492 is a potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.
CSN22652 4-HQN 491-36-1 4-HQN is a PARP inhibitor with IC50 of 9.5 μM.
CSN23081 Rucaparib Camsylate 1327258-57-0
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