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Transforming Growth Factor beta (TGFβ) Receptor

TGF-beta Receptor

货号 产品名 CAS号 信息
CSN16619 2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 627536-09-8 SD-208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50= 49 nM) and displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively.
CSN16734 SB-505124 694433-59-5 SB505124 is an inhibitor of TGFβ receptor for ALK4 (IC50 = 129 nM) and ALK5 (IC50 = 47 nM). It can also inhibit ALK7.
CSN11900 SB 431542 301836-41-9 SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold selective for ALK5 than p38 MAPK and other kinases.
CSN13435 SB-525334 356559-20-1 SB-525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.
CSN13732 SB-505124 HCl 356559-13-2 SB-505124 HCl is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.
CSN12299 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine   446859-33-2 RepSox is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively.
CSN18520 R-268712 879487-87-3 R268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM.
CSN26776 PF-06952229 1801333-55-0 PF-06952229 is a potent, selective and orally active TGFbR1 inhibitor. PF-06952229 specifically binds to TGFbR1 and prevents TGFbR1-mediated signal transduction. PF-06952229 is a promising antineoplastic agent for the study solid tumors, especifically metastatic breast cancer.
CSN15840 ML347 1062368-49-3 ML347 is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM and shows > 300-fold selectivity for ALK2 vs. ALK3.
CSN11348 4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)quinoline 396129-53-6 LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, exhibits 7-fold selectivity over TGFβR-II.
CSN13685 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 700874-72-2 LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM in a cell-free assay.
CSN13478 LY2109761 700874-71-1 LY2109761 is a selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively and is shown to negatively affect the phosphorylation of Smad2.
CSN13876 LDN-214117 1627503-67-6 LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM with > 100 fold selectivity for ALK5, and also inhibits BMP6 (IC50=100 nM).
CSN17852 LDN-212854 1432597-26-6 LDN-212854 is an inhibitor of BMP and can inhibit ALK2 with IC50 of 1.3 nM. It is used to prevent heterotopic ossification.
CSN13848 LDN193189 1062368-24-4 LDN-193189 is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
CSN13849 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline hydrochloride   1062368-62-0 LDN-193189 HCl is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
CSN22554 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline dihydrochloride 1435934-00-1 LDN-193189 2HCl is a potent and selective ALK2 and ALK3 inhibitor.
CSN15921 K02288 1431985-92-0 K02288 is an inhibitor of type I BMP receptor. It targeting ALK2, ALK1 and ALK6 with IC50 of 1.1, 1.8, 6.4 nM, respectively.
CSN13159 GW788388 452342-67-5 GW788388 is a selective ALK5 inhibitor with IC50 of 18 nM and also inhibits TGF-β type II receptor and activin type II receptor.
CSN15909 Vactosertib 1352608-82-2 EW-7197 is a selective inhibitor of TGF-β receptor ALK4 and ALK5 with IC50s of 13 nM and 11 nM.
CSN22227 Vactosertib HCl 1352610-25-3 EW-7197 HCl is a small-molecule ATP-competitive inhibitor of TGFβRI (ALK5) with an IC50 of 12.9 nM.
CSN17559 DMH-1 1206711-16-1 DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/< 5 nM for ALK1/2/3 respectively and inactive on ALK5, BMPR2, AMPK and VEGFR2.
CSN27624 BMS-986260 2001559-19-7 BMS-986260 is a potent, selective, and orally bioavailable TGFβR1 inhibitor, with IC50 of 1.6 nM.
CSN19475 A 77-01 607737-87-1 A77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
CSN24277 3-(6-Methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide, Sodium salt 2828431-89-4 A 83-01 Sodium Salt is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7, with IC50 values of 12, 45 and 7.5 nM, respectively.
CSN13090 A 83-01 909910-43-6 A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7, with IC50 values of 12, 45 and 7.5 nM, respectively.
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