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Cathepsin

Cathepsin

货号 产品名 CAS号 信息
CSN17677 VBY-825 1310340-58-9 VBY-825 is a reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V.
CSN25645 Relacatib 362505-84-8 Relacatib is developed as a cathepsin K inhibitor but has activity against cathepsin L that may provide potential to block SARS-Cov-2 entry into host cells.
CSN25351 Petesicatib 1252637-35-6 Petesicatib is a cathepsin S inhibitor, used in immune diseases research.
CSN20340 ONO-5334 868273-90-9 ONO-5334 is a potent and orally available inhibitor of cathepsin K (Ki values of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat respectively).
CSN13484 Odanacatib 603139-19-1 Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S.
CSN22465 MIV-247 1352817-76-5 MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.
CSN10529 MG-101 110044-82-1 MG-101 is a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).
CSN20392 MDL28170 88191-84-8 MDL28170 is a potent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. MDL28170 rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.
CSN17411 Leupeptin Hemisulfate 103476-89-7 Leupeptin Hemisulfate is a reversible serine/cysteine protease inhibitor, inhibits cathepsins B, H, L, and S, calpain, and trypsin.
CSN27215 (S)-2-Amino-4-mercaptobutanoic acid 6027-13-0 L-Homocysteine, a homocysteine metabolite, is a homocysteine that has L configuration. L-Homocysteine induces upregulation of cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia .
CSN22874 L 006235 294623-49-7 L 006235 is a potent, reversible cathepsin K inhibitor with IC50 of 0.25 nM.
CSN13069 Furan-2-Carboxylic Acid 88-14-2 Furan-2-carboxylic acid, a natural product isolated and purified from the herbs of Hexagonia speciosa with anti-bacterial effect, is also an orally active selective human cathepsin K inhibitor which may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosis.
CSN23117 SID 26681509 958772-66-2 Cathepsin L inhibitor
CSN19174 Cathepsin Inhibitor 1 225120-65-0 Cathepsin inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
CSN22995 Calpain Inhibitor II 145757-50-2 Calpain Inhibitor II is an inhibitor of calpain.
CSN16115 CA-074 Methyl Ester 147859-80-1 CA-074 Methyl Ester is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor.
CSN22577 5,5-Dimethyl-2,4-oxazolidinedione 695-53-4 5,5-Dimethyl-2,4-oxazolidinedione is a cathepsin K inhibitor, it's an anticonvulsant.
CSN25375 2-cyano-Pyrimidine 14080-23-0 2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos.
CSN14152 1-Hydroxyrutaecarpine 53600-24-1 1-Hydroxyrutaecarpine, a natural product isolated and purified from the fruits of Evodia rutaecarpa (Juss.) Benth., exhibits cytotoxicities (ED50 values < 4 mg/mL) against P-388 or HT-29 cell lines in vitro and antiplatelet activity induced by AA and shows an IC50 value of ca.1-2 mg/mL.
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