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LRRK2

LRRK2

货号 产品名 CAS号 信息
CSN15765 PF-06447475 1527473-33-1 PF-06447475 is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 values of 3 nM, possessing neuroprotective activity.
CSN19704 MLi-2 1627091-47-7 MLi-2 is a highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity.
CSN15891 LRRK2-IN-1 1234480-84-2 LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 values of 6 and 13 nM for G2019S mutant and wild-type LRRK2, respectively.
CSN17129 JH-II-127 1700693-08-8 JH-II-127 is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 values of 2.2, 6.6 and 47.7 nM for G2019S-mutant, wild-type and A2016T-mutant LRRK2, respectively.
CSN17279 HG-10-102-01 1351758-81-0 HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 (IC50=23.3 nM) and the G2019S mutant (IC50=3.2 nM)
CSN15754 GSK2578215A 1285515-21-0 GSK2578215A is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 values of 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2, respectively.
CSN15912 GNE-0877 1374828-69-9 GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM.
CSN17916 GNE-9605 1536200-31-3 GNE-9605 is a selective and potent LRRK2 with IC50 value of 18.7 nM.
CSN18902 GNE-7915 Tosylate 2070015-00-6 GNE-7915 tosylate is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM.
CSN17181 GNE-7915 1351761-44-8 GNE-7915 is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 value of 9 nM.
CSN16309 CZC-54252 1191911-27-9 CZC-54252 is a potent LRRK2 inhibitor with IC50 values of 1.28 nM and 1.85 nM for wild-type and G2019S mutant LRRK2, respecitively, possessing neuroprotective effect.
CSN17277 CZC-25146 1191911-26-8 CZC-25146 is a potent LRRK2 inhibitor with IC50 values of 4.76 and 6.87 nM for for wild-type and G2019S mutant LRRK2, respectively. It also inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2.
CSN17694 CZC-25146 HCl 1330003-04-7 CZC-25146 hydrochloride is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively.
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