Small Ubiquitin-like Modifier (or SUMO) proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells to modify their function.
|CSN24144||TAK-981||1858276-04-6||TAK-981 is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities.|
|CSN20617||ML-792||1644342-14-2||ML-792 is a mechanism-based SUMO-activating enzyme (SAE) inhibitor with nanomolar potency in cellular assays, which selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation.|
|CSN11097||Ginkgolic Acid||22910-60-7||Ginkgolic acid is a natural product isolated and purified from the leaves of Ginkgo biloba L.with suspected cytotoxic, allergenic, mutagenic and carcinogenic properties.|
|CSN23876||COH000||1534358-79-6||COH000 is an irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) with IC50 of 0.2 μM for SUMOylation in vitro.|