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Raf

Raf

货号 产品名 CAS号 信息
CSN12243 ZM336372 208260-29-1 ZM336372 is an inhibitor of c-Raf with IC50 of 70 nM.
CSN22915 XRK3F2 2375193-43-2 XRK3F2 is a p62-ZZ domain inhibitor which can blunt MM-induced Runx2 suppression and induce new bone formation and remodeling.
CSN15889 TAK-632 1228591-30-7 TAK-632 is a selective pan-RAF kinase inhibitor with IC50 values of 2.4/1.4 nM for BRAF V600E/c-RAF with > 60 fold selectivity over VEGFR.
CSN16576 SB-590885 405554-55-4 SB-590885 is a potent B-Raf inhibitor with Ki of 0.16 nM, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases.
CSN18623 Ro 5126766 946128-88-7 Ro 5126766 is a unique and allosteric MEK/RAF signaling inhibitor with IC50 values of 8.2, 19, 56 and 160nM for BRAFV600E mutant, BRAF, CRAF and MEK1, respectively.
CSN21013 Praeruptorin B 81740-07-0 Praeruptorin B is extracted from umbelliferae peucedanum praeruptorum, it has found that praeruptorin B improves diet-induced hyperlipidemia and alleviates insulin resistance via regulating SREBP signaling pathway.
CSN17782 PLX7904 1393465-84-3 PLX7904 is a Raf inhibitor, inhibits the growth of two melanoma cell lines (A375 and COLO829) and human colorectal cancer cell line COLO205 that expressed BRAFV600E with IC50 values of 0.17 μM, 0.53 μM, and 0.16 μM, respectively.
CSN21057 Paclitaxtide N/A Paclitaxtide is in phase III clinical trials for the treatment of breast cancer and non small cell lung cancer (NSCLC).
CSN21043 N-(3-Methoxybenzyl)oleamide N/A N-(3-Methoxybenzyl)oleamide can be isolated from the herbs of lepidium meyenii walp.
CSN24793 rel-5-[[(1R,1aS,6bR)-1a,6b-Dihydro-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1H-cyclopropa[b]benzofuran-5-yl]oxy]-3,4-dihydro-1,8-naphthyridin-2(1H)-one 1446090-77-2 Lifirafenib (BGB-283) is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively.
CSN12290 L-779450 303727-31-3 L-779450 is a potent, ATP-competitive Raf kinase inhibitor (IC50 =10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively.
CSN21992 Lifirafenib 1446090-79-4 In vitro, BGB-283 potently inhibits BRAFV600E-activated ERK phosphorylation and cell proliferation.
CSN16951 HG6-64-1 1315329-43-1 HG6-64-1 is a potent and selective B-Raf and mutant B-Raf inhibitor.
CSN12428 GDC-0879 905281-76-7 GDC-0879 is a potent, and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well, displaying no inhibition known to other protein kinases.
CSN17126 CEP-32496 HCl 1227678-26-3 CEP-32496 HCl is a highly potent inhibitor of BRAF (V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2, respectively, displaying insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2.
CSN21971 CCT196969 1163719-56-9 CCT196969 is active against melanoma and colorectal cancer cell lines that are mutant for BRAF, but not cancer cells that are wild-type for BRAF and NRAS. CCT196969 induces caspase 3 and PARP cleavage, thus induces apoptosis. CCT196969 does not drive paradoxical pathway activation and inhibit MEK/ERK in BRAF and NRAS mutant melanoma.
CSN12390 BRAF Inhibitor 918505-61-0 BRAF inhibitor is a potent BRAF inhibitor.
CSN24795 BI-882370 1392429-79-6 BI-882370 is a potent and selective RAF kinase inhibitor that binds to the ATP binding site of the kinase positioned in the DFG-out (inactive) conformation of the BRAF kinase. BI-882370 (BI 882370) inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF kinases with IC50s of 0.4, 0.8, and 0.6 nM, respectively. BI-882370 also inhibits SRC family kinases[1].
CSN13581 B-Raf Inhibitor 1315330-11-0 B-Raf inhibitor, a pyrazine and pyrrolo[2,3-b]pyridine derivative, is useful in the treatment of cancer and proliferative diseases.
CSN16988 B-Raf IN 1 950736-05-7 B-Raf IN 1 is a highlt potent and selective B-Raf inhibitor with IC50 of 24 nM, equipotent against c-Raf (IC50= 25 nM).
CSN13566 AZ 628 878739-06-1 AZ 628 is a pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.
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