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货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN24787 | Unesbulin | 1610964-64-1 | PTC596 is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. PTC596 targets BMI1 expressed by both tumor cells and cancer stem cells (CSCs), and induces hyper-phosphorylation of BMI1, leading to its degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells[1][2]. |
CSN17180 | PTC-209 | 315704-66-6 | PTC-209 is a specific inhibitor for BMI-1 with IC50 of 0.5 μM in in both GEMS reporter and ELISA assays. |
CSN23234 | PTC-028 | 1782970-28-8 | PTC-028 can decrease BMI-1 levels by posttranslational modification. |
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