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PLK

PLK

货号 产品名 CAS号 信息
CSN23160 TC-S 7005 1082739-92-1 TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively[1].
CSN17496 TAK-960 HCl 2108449-45-0 TAK-960 HCl is an investigational, orally bioavailable, potent, and selective PLK1 inhibitor (IC50=1.5 nM) that has shown activity in several tumor cell lines, including those that express multidrug-resistant protein 1 (MDR1).
CSN18428 SBE13 775294-82-1 SBE13 is a potent and selective PLK1 with IC50 of 0.2 nM and displays no inhibition om Aurora A kinase, Plk2 and Plk3.
CSN16422 Ro 3280 1062243-51-9 RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.
CSN18787 Rigosertib Sodium 592542-60-4 Rigosertib sodium is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM.
CSN18210 Poloxin 321688-88-4 Poloxin is a non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor that targets the polo-box domain.
CSN18009 Poloxime 17302-61-3 Poloxime is an analogue of thymoquinone, which bind to the phosphoserine/phosphothreonine recognition site of the polo-box domain of polo-like kinase 1.
CSN16295 NMS-1286937 1034616-18-6 NMS-1286937 is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor (IC50=2 nM) with potential antineoplastic activity and no inhibition on PLK2 and PLK3.
CSN16314 MLN0905 1228960-69-7 MLN0905 is a small-molecule and potent inhibitor of PLK1 with IC50 of 2 nM.
CSN18151 LFM-A13 244240-24-2 LFM-A13 is a potent and selective inhibitor of Btk with IC50 of 17.2 μM and also inhibits PLK3 with IC50 of 7.2 μM.
CSN16519 HMN-214 173529-46-9 HMN-214 is a potent PLK1 inhibitor an average IC50 of 0.12 μM, and a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1.
CSN12710 GW843682X 660868-91-7 GW843682X is a selective PLK1 and PLK3 inhibitor with IC50s of 2.2 nM (PLK1) and 9.1 nM (PLK3) and displays > 100-fold selectivity over ~30 other kinases tested including cdk1 and cdk2.
CSN22785 Cyclapolin 9 40533-25-3 Cyclapolin 9 is a selective, ATP-competitive polo-like kinase 1 (PLK1) inhibitor with IC50 of 500 nM.
CSN18037 Centrinone-B 1798871-31-4 Centrinone-B is a high affinity and selective PLK4 inhibitor (Ki = 0.59 nM).
CSN17208 Centrinone 1798871-30-3 Centrinone is a selective and reversible inhibitor of polo-like kinase 4 (Plk4), a serine-threonine protein kinase that initiates centriole/centrosome assembly.
CSN12461 BI-2536 755038-02-9 BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM, BI2536 shows 4- and 11-fold greater selectivity against Plk2 and Plk3 and also is a BRD4 inhibitor (IC50= 25 nM).
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