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PPAR

PPAR

货号 产品名 CAS号 信息
CSN12217 Wy-14643 50892-23-4 Wy-14643 is an agonist of PPARα with EC50 of 0.63 μM that can decrease the inflammatory response. It has other functions including lipid metabolism, cell proliferation, differentiation, adipogenesis etc..
CSN12155 Troglitazone 97322-87-7 Troglitazone is a PPARγ agonist with EC50 of 780 nM in murine and 555 nM in human. It has no activity at PPARα or PPARδ and can act as an anti-diabetic agent.
CSN18774 T0070907 313516-66-4 T0070907 is an antagonist of PPARγ with IC50 of 1 nM.
CSN20285 Suksdorfin 53023-17-9 Suksdorfin promotes adipocyte differentiation and improves abnormalities in glucose metabolism via PPARγ activation.
CSN20554 Seladelpar 851528-79-5 Seladelpar is selectively exhibits activation of peroxisome proliferator-activated receptor δ (PPARδ) which may has therapeutic activity against dyslipidemia, metabolic syndrome, type 2 diabetes, and non-alcoholic steatohepatitis.
CSN16902 Saroglitazar 495399-09-2 Saroglitazar is a peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity withEC50values of 0.65 pM and 3 nM in HepG2 cells, respectively.
CSN12570 Rosiglitazone Maleate 155141-29-0 Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ (PPARγ) with Kd of 40 nM and it also acts as a modulator of TRP channels.
CSN12512 Rosiglitazone   122320-73-4 Rosiglitazone is a selective agonist of PPARγ with EC50 of 60 nM, and has no effect on PPARα and PPARβ. It is an insulin sensitizing and potent antihyperglycemic agent.
CSN10123 Rosiglitazone HCl 302543-62-0 Rosiglitazone hydrochloride is a blood glucose-lowering drug, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
CSN22489 Pparδ Agonist 942594-93-6 PPARδ agonist is a PPARδ agonist extracted from patent US20180071304, compound example 10.
CSN22490 Pparδ Agonist 1 1902161-12-9 Pparδ agonist 1 is a PPAR-δ agonist, with an EC50 of 5.06 nM, used in the research of PPAR-delta related diseases, such as mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases.
CSN10029 Pioglitazone 111025-46-8 Pioglitazone is an agonist of peroxisome proliferator-activated receptor gamma (PPARγ, EC50 = 500-600 nM) over PPAR⍺. It also a thiazolidinedione (TZD) anti-diabetic.
CSN12489 Pioglitazone HCl 112529-15-4 Pioglitazone hydrochloride is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes.
CSN18945 Pemafibrate 848259-27-8 Pemafibrateis a selective PPARα modulator (SPPARMα) that has antihyperlipidaemic activity.
CSN18946 Pemafibrate Racemate 848258-31-1 Pemafibrate racemate is a selective PPARα modulator (SPPARMα).
CSN11647 Palmitoylethanolamide 544-31-0 Palmitoylethanolamide, endogenous fatty acid amide, is an agonist of PPAR-α in vitro with an EC50 value of 3.1 ± 0.4 μM. It can be used for preventing the infection of virus.
CSN20649 Oleoylethanolamide 111-58-0 Oleoylethanolamide is a lipid mediator and analog of anandamide that is involved in peripheral regulation of feeding. It is also a selective GPR55 agonist (EC50 values are 0.44, > 30 and > 30 μM at GPR55, CB1 and CB2 respectively) and PPARα agonist (EC50 = 120 nM).
CSN20225 MHY553 6265-56-1 MHY553, a PPARα agonist, alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging.
CSN11258 L-165,041 79558-09-1 L-165041 is a cell permeable PPARδ agonist which induces adipocyte differentiation in NIH-PPARδ cells.
CSN20539 IVA-337 927961-18-0 IVA-337 is a agonist of peroxisome proliferator-activated receptors (PPAR) which is widely used in the study of lung fibrosis and pulmonary hypertension.
CSN11131 GW9662 22978-25-2 GW9662 selectively antagonizes PPARγ with IC50 of 3.3 nM. It can inhibit the growth of mammary cancer cells.
CSN12843 GW501516 317318-70-0 GW501516 is a selective agonist of PPARβ/δ with EC50 of 1 nM and is a potential candidate for the treatment of metabolic diseases and cardiovascular diseases.
CSN11130 GW1929 196808-24-9 GW1929 is a synthetic peroxisome proliferator-activated receptor-γ (PPARγ) agonist with IC50 of 6.2 nM and 13 nM for human and mouse PPARγ, respectively.
CSN13142 GW0742 317318-84-6 GW0742 is an agonist of PPARδ with EC50 of 1.1 nM. It can protect right heart from hypertrophy and enhance lipid metabolism in heart.
CSN22426 GW 6471 880635-03-0 GW 6471 is a potent PPARα antagonist.
CSN15822 GSK3787 188591-46-0 GSK3787 selectively and irreversibly antagonizes PPARδ with pIC50 of 6.6 with no significant effect on hPPARα or hPPARγ.
CSN15777 GSK0660 1014691-61-2 GSK0660 is a selective antagonist of PPARβ/δ and exhibits inverse agonist effects when used alone.
CSN16260 Gemfibrozil 25812-30-0 Gemfibrozil is an agonist of PPARα. It can act as a hyperlipidemic agent that elevates plasma HDL and lowers triglycerides.
CSN22403 Fonadelpar 515138-06-4 Fonadelpar is a PPARδ agonist, used in the research of neuroparalytic keratopathy.
CSN18750 Fenofibric Acid 42017-89-0 Fenofibric acid is an agonist of PPAR that can regulate lipid level. It also exhibits inhibition of COX-2.
CSN12680 Fenofibrate 49562-28-9 Fenofibrate is an agonist of PPARα (EC50 = 30 μM) and an inhibitor of CYP2C19 (IC50 = 0.2 μM) and CYP2B6 (IC50 = 0.7 μM). Fenofibrate is a fibric acid derivative and used to treat hypercholesterolemia and hypertriglyceridemia.
CSN16153 Elafibranor 923978-27-2 Elafibranor is an agonist of PPARα and PPARδ with EC50 values of 45 nM and 175 nM, respectively. Elafibranor also attenuates nonalcoholic steatohepatitis without fibrosis worsening.
CSN17750 DG172 2HCl 1361504-77-9 DG172 dihydrochloride is a PPARβ/δ-selective ligand showing high binding affinity (IC50 = 27 nM) and potent inverse agonistic properties.
CSN13070 Clofibric Acid 882-09-7 Clofibric acid is an agonist of PPARα and can act as a hypolipidemic agent.
CSN11481 Clofibrate 637-07-0 Clofibrate, a fibric acid derivative, is a selective agonist of peroxisome proliferator-activated receptor α (PPARα) with EC50 of 50 µM. Clofibrate has been used to treat hyperlipoproteinemia type III and severe hypertriglyceridemia.
CSN10653 Ciprofibrate 52214-84-3 Ciprofibrate is an agonist of peroxisome proliferator-activated receptor PPAR⍺. It is used in dyslipidaemia.
CSN18278 CDDO-Im 443104-02-7 CDDO-Im is a synthetic triterpenoid more potent than its parent compound CDDO both in vitro and in vivo and a PPARγ agonist.
CSN17378 BMS-687453 1000998-59-3 BMS-687453 is a potent and selective PPARα agonist, with an EC50 of 10 nM for human PPARα and 410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays.
CSN10445 Bezafibrate 41859-67-0 Bezafibrate is the agonist of PPAR and the EC50 for PPAR⍺, PPARβ, PPARẟ is 50 , 20, and 60 nM respectively. It has hypolipidemic effect.
CSN18081 Balaglitazone 199113-98-9 Balaglitazone is a partial agonist of PPAR-γ.
CSN14141 Arjunolic Acid 465-00-9 Arjunolic acid, a natural peroxisome proliferator-activated receptor alpha agonist isolated and purified from the fruits of Terminalia chebula Retz., can protect against cisplatin-induced testicular injury by attenuating oxidative stress parameters along with downregulation of iNOS, TNF-α, and p38-MAPK testicular expressions.
CSN20181 AMG-131 315224-26-1 AMG-131 is a hypoglycemic agent. It is a potent PPARγ partial agonist that displays robust glucose-lowering activity in rodent models of diabetes while exhibiting a reduced side-effects profile compared to marketed TZDs.
CSN10234 Aleglitazar 475479-34-6 Aleglitazar is a dual PPAR-α/γ agonist with IC50 of 2.8 nM/4.6 nM.
CSN12767 4-(4-Hydroxyphenyl)-2-Butanone 5471-51-2 4-(4-Hydroxyphenyl)-2-butanone is the primary aroma compound of red raspberries and shows PPAR-α agonistic activity.
CSN22773 CP 775146 702680-17-9
CSN22845 GW 1929 HCl 1217466-21-1
CSN22759 Ciglitazone 74772-77-3
CSN22800 Edaglitazone 213411-83-7
CSN22706 BADGE 1675-54-3
CSN23127 SR 202 76541-72-5
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