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PPAR

PPAR

货号 产品名 CAS号 信息
CSN26416 Tesaglitazar 251565-85-2 Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively, and approximately 0.2 μM for both rat and human PPARγ. Tesaglitazar induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats[1].
CSN18774 2-Chloro-5-nitro-N-(pyridin-4-yl)benzamide 313516-66-4 T0070907 is an antagonist of PPARγ with IC50 of 1 nM.
CSN20285 Suksdorfin 53023-17-9 Suksdorfin promotes adipocyte differentiation and improves abnormalities in glucose metabolism via PPARγ activation.
CSN23126 SR1664 1338259-05-4 SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50 = 80 nM; Ki = 28.67 nM) without exhibiting PPARγ agonist activity.
CSN23127 Mifobate 76541-72-5 SR 202 is a selective PPARγ antagonist which attenuates troglitazone-induced PPARγ transcriptional activity with IC50 value of 140μM. It inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo and improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo.
CSN32930 (R)-2-(4-((2-Ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid compound with (S)-2,6-diaminohexanoic acid dihydrate 928821-40-3 Seladelpar lysine is a selective PPAR-δ agonist.
CSN20554 Seladelpar 851528-79-5 Seladelpar is selectively exhibits activation of peroxisome proliferator-activated receptor δ (PPARδ) which may has therapeutic activity against dyslipidemia, metabolic syndrome, type 2 diabetes, and non-alcoholic steatohepatitis.
CSN22093 Saroglitazar magnesium 1639792-20-3 Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ in HepG2 cells, respectively.
CSN16902 Saroglitazar 495399-09-2 Saroglitazar is a peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity withEC50values of 0.65 pM and 3 nM in HepG2 cells, respectively.
CSN33127 Mavodelpar 1604815-32-8 REN-001 is a PPARdelta agonist.
CSN22489 Mavodelpar free acid 942594-93-6 PPARδ agonist is a PPARδ agonist extracted from patent US20180071304, compound example 10.
CSN22490 Pparδ agonist 1 1902161-12-9 Pparδ agonist 1 is a PPAR-δ agonist, with an EC50 of 5.06 nM, used in the research of PPAR-delta related diseases, such as mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases.
CSN18945 pemafibrate 848259-27-8 Pemafibrateis a selective PPARα modulator (SPPARMα) that has antihyperlipidaemic activity.
CSN18946 Pemafibrate racemate 848258-31-1 Pemafibrate racemate is a selective PPARα modulator (SPPARMα).
CSN25412 Oroxin A 57396-78-8 Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE), activates peroxisome proliferator-activated receptor γ (PPARγ) by docking into the PPARγ protein ligand-binding domain. Oroxin A exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence.
CSN20649 Oleoylethanolamide 111-58-0 Oleoylethanolamide is a lipid mediator and analog of anandamide that is involved in peripheral regulation of feeding. It is also a selective GPR55 agonist (EC50 values are 0.44, > 30 and > 30 μM at GPR55, CB1 and CB2 respectively) and PPARα agonist (EC50 = 120 nM).
CSN13703 MK-886 118414-82-7 MK886 is an inhibitor of 5-lipoxygenase activating protein (FLAP), PPARα, and the biosynthesis of leukotriene (LT).
CSN20225 MHY553 6265-56-1 MHY553, a PPARα agonist, alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging.
CSN25571 MA-0204 2095128-17-7 MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. It is potential for Duchene Muscular Dystrophy treatment.
CSN23900 LJ570 2252488-69-8 LJ570 is the first PPARα/γ dual agonist with EC50 values of 1.05 and 0.12 μM, respectively.
CSN33142 Leriglitazone 146062-44-4 Leriglitazone is a peroxisome proliferator activated receptor (PPAR) gamma agonist.
CSN20539 Lanifibranor 927961-18-0 IVA-337 is a agonist of peroxisome proliferator-activated receptors (PPAR) which is widely used in the study of lung fibrosis and pulmonary hypertension.
CSN21901 Imiglitazar 250601-04-8 Imiglitazar is a potent and dual human PPARα and PPARγ1 agonist with EC50 values of 67 and 31 nM, respectively.
CSN27564 Gypenoside XLIX 94987-08-3 Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells.
CSN26116 GW7647 265129-71-3 GW7647 is a potent human PPARα agonist with EC50 value of 6nM.
CSN22426 GW6471 880635-03-0 GW 6471 is a potent PPARα antagonist.
CSN22845 GW1929 hydrochloride 1217466-21-1 GW 1929 HCl is a highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist with pEC50 of 8.05 for human PPARγ.
CSN22403 Fonadelpar 515138-06-4 Fonadelpar is a PPARδ agonist, used in the research of neuroparalytic keratopathy.
CSN15096 Ficusin A 173429-83-9 Ficusin A is a natural product isolated and purified from the seeds of Psoralea corylifolia Linn.
CSN17195 FH535 108409-83-2 FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling.
CSN18750 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 42017-89-0 Fenofibric acid is an agonist of PPAR that can regulate lipid level. It also exhibits inhibition of COX-2.
CSN22800 Edaglitazone 213411-83-7 Edaglitazone is a potent and selective PPARγ agonist with EC50 of 35.61 nM.
CSN27742 Diflapolin 724453-98-9 Diflapolin is a dual inhibitor of both FLAP and sEH. It inhibited 5-LOX product formation in intact human monocytes and neutrophils with IC50 = 30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC50 = 20 nM).
CSN17750 DG172 2HCl 1361504-77-9 DG172 2HCl is a PPARβ/δ-selective ligand showing high binding affinity (IC50 = 27 nM) and potent inverse agonistic properties.
CSN26559 CUDA 479413-68-8 CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively[1]. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease[2].
CSN22773 CP-775146 702680-17-9 CP 775146 is a selective, high affinity PPARα agonist with Ki of 24.5 nM.
CSN25193 3-Phenylprop-2-en-1-ol 104-54-1 Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon.
CSN22759 Ciglitazone 74772-77-3 Ciglitazone is a selective agonist at PPARγ (peroxisome proliferator-activated receptor γ) with an EC50 of 3 μM in vitro.
CSN18278 CDDO-Im 443104-02-7 CDDO-Im is a synthetic triterpenoid more potent than its parent compound CDDO both in vitro and in vivo and a PPARγ agonist.
CSN17378 BMS-687453 1000998-59-3 BMS-687453 is a potent and selective PPARα agonist, with an EC50 of 10 nM for human PPARα and 410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays.
CSN18081 Balaglitazone 199113-98-9 Balaglitazone is a partial agonist of PPAR-γ.
CSN22706 2,2-Bis(4-glycidyloxyphenyl)propane 1675-54-3 BADGE is a PPARγ antagonist.
CSN21934 AVE-8134 304025-09-0 AVE-8134 is a potent PPARα agonist with EC50 of 100 and 3000 nM for human and rodent PPARα receptor, respectively.
CSN22075 Arhalofenate 24136-23-0 Arhalofenate is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ ans is used for the treatment of type 2 diabetes.
CSN20181 AMG131 315224-26-1 AMG-131 is a hypoglycemic agent. It is a potent PPARγ partial agonist that displays robust glucose-lowering activity in rodent models of diabetes while exhibiting a reduced side-effects profile compared to marketed TZDs.
CSN51362 SR 16832 2088135-12-8
CSN62538 (S)-Coriolic acid 29623-28-7
CSN51560 (9Z,11E)-13-Oxooctadeca-9,11-dienoic acid 54739-30-9
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